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Carbon-Nanotube-Based Monolithic CMOS Platform for Electrochemical Detection of Neurotransmitter Glutamate

1
Bio Engineering Laboratory, Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland
2
MaxWell Biosystems AG, CH-4058 Basel, Switzerland
*
Author to whom correspondence should be addressed.
Sensors 2019, 19(14), 3080; https://doi.org/10.3390/s19143080
Received: 4 May 2019 / Revised: 2 July 2019 / Accepted: 3 July 2019 / Published: 12 July 2019
(This article belongs to the Section Biosensors)
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Abstract

We present a monolithic biosensor platform, based on carbon-nanotube field-effect transistors (CNTFETs), for the detection of the neurotransmitter glutamate. We used an array of 9′216 CNTFET devices with 96 integrated readout and amplification channels that was realized in complementary metal-oxide semiconductor technology (CMOS). The detection principle is based on amperometry, where electrochemically active hydrogen peroxide, a product of the enzymatic reaction of the target analyte and an enzyme that was covalently bonded to the CNTFET, modulated the conductance of the CNTFET-based sensors. We assessed the performance of the CNTs as enzymatic sensors by evaluating the minimal resolvable concentration change of glutamate in aqueous solutions. The minimal resolvable concentration change amounted to 10 µM of glutamate, which was one of the best values reported for CMOS-based systems so far. View Full-Text
Keywords: carbon nanotube field-effect transistor; CMOS; ion-sensitive field-effect transistors; ChemFET carbon nanotube field-effect transistor; CMOS; ion-sensitive field-effect transistors; ChemFET
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Dudina, A.; Frey, U.; Hierlemann, A. Carbon-Nanotube-Based Monolithic CMOS Platform for Electrochemical Detection of Neurotransmitter Glutamate. Sensors 2019, 19, 3080.

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