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Communication

Synthesis of New 1,2,3,4-Tetrahydroquinoline Hybrid of Ibuprofen and Its Biological Evaluation

Department of Organic Chemistry, Faculty of Chemistry, University of Plovdiv, 24 Tzar Assen str., 4000 Plovdiv, Bulgaria
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Author to whom correspondence should be addressed.
Academic Editor: Stanislav Kafka
Molbank 2022, 2022(1), M1350; https://doi.org/10.3390/M1350
Received: 4 February 2022 / Revised: 28 February 2022 / Accepted: 3 March 2022 / Published: 7 March 2022
(This article belongs to the Special Issue Quinoline, Derivatives and Applications)
Herein we report the obtaining of 1-(3,4-dihydroquinolin-1(2H)-yl)-2- (4-isobutylphenyl)propan-1-one and its characterization. The newly obtained hybrid and its derivatives (hybrids of ibuprofen with 1,2,3,4-tetrahydroisoquinoline, and piperidine) were screened for their in vitro antioxidant, antitryptic, and inhibition of albumin denaturation activity. The lipophilicity was established using both reversed-phase thin layer chromatography and in silico calculations. View Full-Text
Keywords: quinoline; ibuprofen; hybrid molecule; in silico; in vitro; antioxidant; antitryptic; anti-inflammatory; lipophilicity; SARS-CoV-2; chloroquine quinoline; ibuprofen; hybrid molecule; in silico; in vitro; antioxidant; antitryptic; anti-inflammatory; lipophilicity; SARS-CoV-2; chloroquine
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MDPI and ACS Style

Manolov, S.; Ivanov, I.; Bojilov, D. Synthesis of New 1,2,3,4-Tetrahydroquinoline Hybrid of Ibuprofen and Its Biological Evaluation. Molbank 2022, 2022, M1350. https://doi.org/10.3390/M1350

AMA Style

Manolov S, Ivanov I, Bojilov D. Synthesis of New 1,2,3,4-Tetrahydroquinoline Hybrid of Ibuprofen and Its Biological Evaluation. Molbank. 2022; 2022(1):M1350. https://doi.org/10.3390/M1350

Chicago/Turabian Style

Manolov, Stanimir, Iliyan Ivanov, and Dimitar Bojilov. 2022. "Synthesis of New 1,2,3,4-Tetrahydroquinoline Hybrid of Ibuprofen and Its Biological Evaluation" Molbank 2022, no. 1: M1350. https://doi.org/10.3390/M1350

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