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Short Note

2-Bromo-3-((1-(7-chloroquinolin-4-yl)-1H-1,2,3-triazol-4-yl)-methoxy)-benzaldehyde

1
Dr. Neher’s Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China
2
State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China
3
School of Pharmacy, Macau University of Science and Technology, Macau 999078, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Luke R. Odell
Molbank 2022, 2022(1), M1351; https://doi.org/10.3390/M1351
Received: 5 February 2022 / Revised: 28 February 2022 / Accepted: 1 March 2022 / Published: 9 March 2022
(This article belongs to the Section Organic Synthesis)
The 1,2,3-triazole ring system can be easily obtained by copper-catalyzed click reaction of azides with alkynes. 1,2,3-Triazole exhibits a myriad of biological activities, including antimalarial, antibacterial, and antiviral activities. We herein reported the synthesis of quinoline-based [1,2,3]-triazole hybrid via Cu(I)-catalyzed click reaction of 4-azido-7-chloroquinoline with alkyne derivative of 2-bromobenzaldehyde. The compound was fully characterized by proton nuclear magnetic resonance (1H-NMR), carbon-13 nuclear magnetic resonance (13C-NMR), heteronuclear single quantum coherence (HSQC), ultraviolet (UV), and high-resolution mass spectroscopies (HRMS). This compound was screened in vitro against two different normal cell lines. Preliminary studies attempted to evaluate its interaction with Delta RBD of spike protein of SARS-CoV-2 by bio-layer interferometry. Finally, the drug-likeness of the compound was also investigated by predicting its pharmacokinetic properties. View Full-Text
Keywords: 1,2,3-triazole; bio-layer interferometry; RBD; SARS-CoV-2 1,2,3-triazole; bio-layer interferometry; RBD; SARS-CoV-2
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MDPI and ACS Style

Yun, X.; Xie, Y.; Ng, J.P.L.; Law, B.Y.K.; Wong, V.K.W.; Coghi, P. 2-Bromo-3-((1-(7-chloroquinolin-4-yl)-1H-1,2,3-triazol-4-yl)-methoxy)-benzaldehyde. Molbank 2022, 2022, M1351. https://doi.org/10.3390/M1351

AMA Style

Yun X, Xie Y, Ng JPL, Law BYK, Wong VKW, Coghi P. 2-Bromo-3-((1-(7-chloroquinolin-4-yl)-1H-1,2,3-triazol-4-yl)-methoxy)-benzaldehyde. Molbank. 2022; 2022(1):M1351. https://doi.org/10.3390/M1351

Chicago/Turabian Style

Yun, Xiaoyun, Yuhan Xie, Jerome P.L. Ng, Betty Y.K. Law, Vincent K.W. Wong, and Paolo Coghi. 2022. "2-Bromo-3-((1-(7-chloroquinolin-4-yl)-1H-1,2,3-triazol-4-yl)-methoxy)-benzaldehyde" Molbank 2022, no. 1: M1351. https://doi.org/10.3390/M1351

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