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Molbank, Volume 2020, Issue 3 (September 2020) – 2 articles

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Open AccessCommunication
Catalytic Addition of Indole-2-Carboxylic Acid to 1-Hexyne
Molbank 2020, 2020(3), M1145; https://doi.org/10.3390/M1145 (registering DOI) - 03 Jul 2020
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Abstract
The synthesis of two novel enol esters, namely hex-1-en-2-yl indole-2-carboxylate and hex-1-en-2-yl 1-(hex-1-en-2-yl)-indole-2-carboxylate, is presented. Both compounds were generated by addition of indole-2-carboxylic acid to 1-hexyne employing [RuCl2(η6-p-cymene)(PPh3)] and [AuCl(PPh3)]/AgPF6, respectively, as catalysts. Full article
(This article belongs to the collection Molecules from Catalytic Processes)
Open AccessShort Note
2-(3,4-Dihydroxyphenyl)-4-(2-(4-nitrophenyl)hydrazono)-4H-chromene-3,5,7-triol
Molbank 2020, 2020(3), M1144; https://doi.org/10.3390/M1144 - 29 Jun 2020
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Abstract
On the basis of the knowledge from traditional herbal and folk medicine, flavonoids are among the most studied chemical classes of natural compounds for their potential activity as phosphodiesterase 5 (PDE5) inhibitors. We here describe the preparation of a semi-synthetic hydrazone derivative of [...] Read more.
On the basis of the knowledge from traditional herbal and folk medicine, flavonoids are among the most studied chemical classes of natural compounds for their potential activity as phosphodiesterase 5 (PDE5) inhibitors. We here describe the preparation of a semi-synthetic hydrazone derivative of quercetin, 2-(3,4-dihydroxyphenyl)-4-(2-(4-nitrophenyl)hydrazono)-4H-chromene-3,5,7-triol, that was obtained via a single-step modification of the natural compound. The product was characterized by NMR, mass spectrometry and HPLC. Preliminary molecular modeling studies suggest that this compound could efficiently interact with PDE5. Full article
(This article belongs to the Special Issue Synthesis of Flavonoids or Other Nature-Inspired Small Molecules)
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