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Open AccessCommunication

Synthesis of γ-Glutamyl Derivatives of Sulfur-Containing Amino Acids in a Multigram Scale via a Two-Step, One-Pot Procedure

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Dipartimento di Chimica, Università degli Studi di Milano via Golgi, 19-20133 Milano, Italy
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Dipartimento di Scienze per gli Alimenti, la Nutrizione e l’Ambiente, Università degli Studi di Milano via Celoria, 2-20133 Milano, Italy
*
Author to whom correspondence should be addressed.
Molbank 2020, 2020(3), M1147; https://doi.org/10.3390/M1147
Received: 15 June 2020 / Revised: 29 June 2020 / Accepted: 6 July 2020 / Published: 10 July 2020
γ-Glutamyl derivatives of sulfur amino acids have been prepared in multigram scale starting from readily available starting materials. The synthesis comprises two one-pot operations, both consisting of two reactions. In the first operation, N-phtaloyl-l-glutamic acid anhydride is obtained from l-glutamic acid and phtalic anhydride. In the second one, N-phtaloyl-l-glutamic acid anhydride is used to acylate amino acids and the N-phtaloyl protecting group is removed. The described approach offers a viable entry to γ-glutamyl derivatives of sulfur-containing amino acids with flavor-enhancer and nutraceutical properties. View Full-Text
Keywords: γ-glutamyl compounds; sulfur amino acids; one-pot synthesis; taste-active compounds; kokumi γ-glutamyl compounds; sulfur amino acids; one-pot synthesis; taste-active compounds; kokumi
MDPI and ACS Style

Speranza, G.; Rabuffetti, M.; Vidović, N.; Morelli, C.F. Synthesis of γ-Glutamyl Derivatives of Sulfur-Containing Amino Acids in a Multigram Scale via a Two-Step, One-Pot Procedure. Molbank 2020, 2020, M1147.

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