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3-(4-Bromophenyl)-4-{[3-hydroxy-6-(hydroxymethyl)-4-oxo-4H-pyran-2-yl](m-tolyl)methyl}isoxazol-5(2H)-one

N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences, 47 Leninsky Prospekt, 119991 Moscow, Russia
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Molbank 2020, 2020(2), M1135; https://doi.org/10.3390/M1135
Received: 24 April 2020 / Revised: 6 May 2020 / Accepted: 12 May 2020 / Published: 13 May 2020
(This article belongs to the Section Organic Synthesis)
In this communication, the electrochemically induced multicomponent transformation of 3-methylbenzaldehyde, 3-(4-bromophenyl)isoxazol-5(4H)-one and kojic acid in n-PrOH in an undivided cell in the presence of sodium bromide was carefully investigated to give 3-(4-bromophenyl)-4-{[3-hydroxy-6-(hydroxymethyl)-4-oxo-4H-pyran-2-yl](m-tolyl)methyl}isoxa- zol-5(2H)-one in good yield. The structure of the new compound was established by means of elemental analysis, mass-, nuclear magnetic resonance and infrared spectroscopy. Furthermore, its structure was determined and confirmed by X-ray analysis. The synthesized compound is a promising compound for different biomedical applications, and, in particular, for the regulation of inflammatory diseases, as shown by docking studies in this research. View Full-Text
Keywords: electrochemistry; 3-methylbenzaldehyde; 3-(4-bromophenyl)isoxazol-5(4H)-one; kojic acid; X-ray structure determination; docking studies electrochemistry; 3-methylbenzaldehyde; 3-(4-bromophenyl)isoxazol-5(4H)-one; kojic acid; X-ray structure determination; docking studies
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Ryzhkova, Y.E.; Ryzhkov, F.V.; Elinson, M.N. 3-(4-Bromophenyl)-4-{[3-hydroxy-6-(hydroxymethyl)-4-oxo-4H-pyran-2-yl](m-tolyl)methyl}isoxazol-5(2H)-one. Molbank 2020, 2020, M1135.

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