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Article

Beneficial Effects of Dinitrosyl Iron Complexes on Wound Healing Compared to Commercial Nitric Oxide Plasma Generator

by
Alexandra Igrunkova
1,*,
Alexey Fayzullin
2,3,
Natalia Serejnikova
2,
Tatiana Lipina
4,
Alexandr Pekshev
5,
Anatoly Vanin
6,
Victoria Zaborova
7,8,
Elena Budanova
9,
Dmitry Shestakov
10,
Igor Kastyro
11 and
Anatoly Shekhter
2
1
Department of Human Anatomy and Histology, N.V. Sklifosovsky Institute of Clinical Medicine, Sechenov First Moscow State Medical University (Sechenov University), Moscow 119991, Russia
2
Department of Experimental Morphology and Biobanking, Institute for Regenerative Medicine, Sechenov First Moscow State Medical University (Sechenov University), Moscow 119991, Russia
3
World-Class Research Center “Digital Biodesign and Personalized Healthcare”, Sechenov First Moscow State Medical University (Sechenov University), Moscow 119991, Russia
4
Department of Cell Biology and Histology, Biological Faculty, Moscow Lomonosov State University, Moscow 119234, Russia
5
Research Institute of Power Engineering, Bauman Moscow State Technical University, Moscow 105005, Russia
6
Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, Chernogolovka 142432, Russia
7
Department of Sports Medicine and Medical Rehabilitation, N.V. Sklifosovsky Institute of Clinical Medicine, Sechenov First Moscow State Medical University (Sechenov University), Moscow 119991, Russia
8
Laboratory of Sports Adaptology, Moscow Institute of Physics and Technology, National Research University, Dolgoprudny 141700, Russia
9
Department of Microbiology, Virology and Immunology Named after A.A. Vorobiev, F. Erismann Institute of Public Health, Sechenov First Moscow State Medical University (Sechenov University), Moscow 119991, Russia
10
Moscow Clinical Scientific Center Named after A. S. Loginov, Moscow 111123, Russia
11
Medical Institute, People’s Friendship University of Russia (RUDN University), Moscow 117198, Russia
 
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*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(5), 4439; https://doi.org/10.3390/ijms24054439
Submission received: 23 January 2023 / Revised: 14 February 2023 / Accepted: 20 February 2023 / Published: 23 February 2023
(This article belongs to the Special Issue Advanced Research on Wound Healing)
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Abstract

Nitric oxide (NO) is a gaseous molecule which plays a key role in wound healing. Previously, we identified the optimal conditions for wound healing strategies using NO donors and an air plasma generator. The aim of this study was to compare the wound healing effects of binuclear dinitrosyl iron complexes with glutathione (B-DNIC-GSH) and NO-containing gas flow (NO-CGF) at their optimal NO doses (0.04 mmol for B-DNIC-GSH and 1.0 mmol for NO-CGF per 1 cm2) in a rat full-thickness wound model over a 3-week period. Excised wound tissues were studied by light and transmission electron microscopy and immunohistochemical, morphometrical and statistical methods. Both treatments had an identical stimulating impact on wound healing, which indicated a higher dosage effectiveness of B-DNIC-GSH compared to the NO-CGF. B-DNIC-GSH spray application reduced inflammation and promoted fibroblast proliferation, angiogenesis and the growth of granulation tissue during the first 4 days after injury. However, prolonged NO spray effects were mild compared to NO-CGF. Future studies should determine the optimal B-DNIC-GSH solution course for a more effective wound healing stimulation.
Keywords: wound healing; nitric oxide; nitric oxide donors; dinitrosyl iron complexes (DNIC); NO-containing gas flow; Plason device; NO-therapy wound healing; nitric oxide; nitric oxide donors; dinitrosyl iron complexes (DNIC); NO-containing gas flow; Plason device; NO-therapy

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MDPI and ACS Style

Igrunkova, A.; Fayzullin, A.; Serejnikova, N.; Lipina, T.; Pekshev, A.; Vanin, A.; Zaborova, V.; Budanova, E.; Shestakov, D.; Kastyro, I.; et al. Beneficial Effects of Dinitrosyl Iron Complexes on Wound Healing Compared to Commercial Nitric Oxide Plasma Generator. Int. J. Mol. Sci. 2023, 24, 4439. https://doi.org/10.3390/ijms24054439

AMA Style

Igrunkova A, Fayzullin A, Serejnikova N, Lipina T, Pekshev A, Vanin A, Zaborova V, Budanova E, Shestakov D, Kastyro I, et al. Beneficial Effects of Dinitrosyl Iron Complexes on Wound Healing Compared to Commercial Nitric Oxide Plasma Generator. International Journal of Molecular Sciences. 2023; 24(5):4439. https://doi.org/10.3390/ijms24054439

Chicago/Turabian Style

Igrunkova, Alexandra, Alexey Fayzullin, Natalia Serejnikova, Tatiana Lipina, Alexandr Pekshev, Anatoly Vanin, Victoria Zaborova, Elena Budanova, Dmitry Shestakov, Igor Kastyro, and et al. 2023. "Beneficial Effects of Dinitrosyl Iron Complexes on Wound Healing Compared to Commercial Nitric Oxide Plasma Generator" International Journal of Molecular Sciences 24, no. 5: 4439. https://doi.org/10.3390/ijms24054439

APA Style

Igrunkova, A., Fayzullin, A., Serejnikova, N., Lipina, T., Pekshev, A., Vanin, A., Zaborova, V., Budanova, E., Shestakov, D., Kastyro, I., & Shekhter, A. (2023). Beneficial Effects of Dinitrosyl Iron Complexes on Wound Healing Compared to Commercial Nitric Oxide Plasma Generator. International Journal of Molecular Sciences, 24(5), 4439. https://doi.org/10.3390/ijms24054439

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