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Open AccessArticle

The Effect of Silver Nanoparticles on Antioxidant/Pro-Oxidant Balance in a Murine Model

1
Department of Toxicology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
2
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
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Department of Biochemistry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
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Department of Microbiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
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Graduate Program in Public Health, Center of Health Sciences, State University of Londrina, 60 Robert Koch Avenue, Londrina 86038-350, Brazil
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Department of Molecular Pharmacology, Albert Einstein College of Medicine, Forchheimer 209,1300 Morris Park Avenue, Bronx, NY 10461, USA
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Department of Pharmacognosy and Phytotherapy, Faculty of Pharmacy University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
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Department of Research Methodology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
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Doctoral School University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
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Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 011061 Bucharest, Romania
11
Department of Histology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(4), 1233; https://doi.org/10.3390/ijms21041233
Received: 31 December 2019 / Revised: 2 February 2020 / Accepted: 7 February 2020 / Published: 12 February 2020
(This article belongs to the Special Issue Nanomedicine, Nanopharmacy and Nanobiomaterials)
This study aimed to evaluate the subacute effect of two types of Ag-NPs(EG-AgNPs and PVP-EG-AgNPs) on antioxidant/pro-oxidant balance in rats. Seventy Wistar rats (35 males and 35 females) were divided in 7 groups and intraperitoneally exposed for 28 days to 0, 1, 2 and 4 mg/kg bw/day EG-Ag-NPs and 1, 2 and 4 mg/kg bw/day PVP- EG-Ag-NPs. After 28 days, the blood was collected, and the total antioxidant capacity (TAC), thiobarbituric reactive species (TBARS),protein carbonyl (PROTC) levels, reduced glutathione (GSH) levels and catalase (CAT) activity were determined. EG-Ag-NPs determined protective antioxidant effects in a dose-dependent manner. The exposure to the 4 mg/kg bw/day EG-Ag-NPs determines both in males and females a significant increase in TAC and CAT and a significant decrease in TBARS and PROTC only in females. The PVP-EG-AgNPs showed a different trend compared to EG-AgNPs. At 4 mg/kg bw/day the PVP-EG-AgNPs induce increased PROTC levels and decreased GSH (males and females) and TAC levels (males). The different mechanisms of EG-AgNPs and PVP-EG-AgNPs on antioxidant-/pro-oxidant balance can be explained by the influence of coating agent used for the preparation of the nanoparticles in the formation and composition of protein corona that influence their pathophysiology in the organism. View Full-Text
Keywords: silver nanoparticles; oxidative stress; antioxidant activity; subacute toxicity silver nanoparticles; oxidative stress; antioxidant activity; subacute toxicity
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Docea, A.O.; Calina, D.; Buga, A.M.; Zlatian, O.; Paoliello, M.; Mogosanu, G.D.; Streba, C.T.; Popescu, E.L.; Stoica, A.E.; Bîrcă, A.C.; Vasile, B.Ș.; Grumezescu, A.M.; Mogoanta, L. The Effect of Silver Nanoparticles on Antioxidant/Pro-Oxidant Balance in a Murine Model. Int. J. Mol. Sci. 2020, 21, 1233.

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