Int. J. Mol. Sci., Volume 21, Issue 4 (February-2 2020) – 376 articles
Cover Story (view full-size image): Antimicrobial resistance (AMR) is a major health concern worldwide. The search both for more efficient treatments and for new classes of antibiotics requires a better understanding of the underlying molecular mechanisms of pathogenesis and AMR. New high-throughput technologies have enabled unbiased insights into the functional genomics of pathogens and their strategies to counter the action of antimicrobials. Here, we review representative bioinformatics methods published in the past five years to define major current approaches to the understanding of AMR mechanisms, prediction of AMR, and the potential for clinical application. View this paper.
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