Int. J. Mol. Sci., Volume 21, Issue 3 (February-1 2020) – 487 articles
Cover Story (view full-size image): RTB lectin is a non-toxic carbohydrate-binding subunit B of ricin toxin with a high affinity for glycolipids and glycoproteins common on human cell surfaces. RTB mediates endocytic uptake and transcytosis in mammalian cells by multiple routes exploiting both adsorptive-mediated and receptor-mediated mechanisms. Upon intravenous infusion, lectin:cargo fusion products attain broad biodistribution, which includes crossing the blood-brain-barrier to deliver bioactive macromolecules to the CNS. This delivery platform may provide novel therapeutic applications to address neurological disorders. View this paper.
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