Radiation-Induced Damage to DNA

Dear Colleague,

Since cancer is the third leading cause of death, radiation-induced damage to DNA is a topic of a paramount importance. Indeed, radiotherapy and photodynamic therapy are common modalities for treating human cancers, and causing efficient damage to the DNA of tumor cells is their main target. The efficacy of the above-mentioned modalities is a serious issue, since solid tumors, which account for c. 80% of cases, are hypoxic, which significantly reduces the extent of primary damage induced either by the ionizing or UV photons.

This Special issue will expose the reader to: the mechanisms of direct and indirect radiation-induced DNA damage, radiation damage to DNA–protein complexes, the computational modeling of radiation damage to DNA, radio- and photosensitizers of DNA damage, repair of radiation-induced DNA damage, the biological consequences of DNA damage, the radiotherapy of cancer, photodynamic therapy, and cellular responses to DNA damage.

The gathered SI articles are expected to provide a reference for recent development in this interdisciplinary and practical subject, with anticancer therapy as a hallmark, to organic and medicinal chemists, radiation and photochemists, molecular modeling chemists, as well as cellular biologists who are in the target audience.

Prof. Dr. Janusz Rak
Dr. Magdalena Zdrowowicz
Guest Editors

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