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Volume 21
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10.3390/ijms21031100
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Article

The Effect of 3′-Hydroxy-3,4,5,4′-Tetramethoxy -stilbene, the Metabolite of the Resveratrol Analogue DMU-212, on the Motility and Proliferation of Ovarian Cancer Cells

by
Andrzej Nowicki
1,
Paulina Skupin-Mrugalska
2,
Malgorzata Jozkowiak
1,
Marcin Wierzchowski
3,
Marcin Rucinski
4,
Piotr Ramlau
1,
Violetta Krajka-Kuzniak
5,
Jadwiga Jodynis-Liebert
1 and
Hanna Piotrowska-Kempisty
1,*
1
Department of Toxicology, Poznan University of Medical Sciences, Dojazd 30 St., PL-60-631 Poznan, Poland
2
Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6 St., 60-780 Poznan, Poland
3
Department of Chemical Technology of Drugs, Poznan University of Medical Sciences, Grunwaldzka 6 St., PL-60-780 Poznan, Poland
4
Department of Histology and Embryology, Poznan University of Medical Sciences, Swiecickiego 6 St., PL-60-781 Poznan, Poland
5
Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, Swiecickiego 4 St., 60-781 Poznan, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(3), 1100; https://doi.org/10.3390/ijms21031100
Received: 18 January 2020 / Revised: 3 February 2020 / Accepted: 4 February 2020 / Published: 7 February 2020
(This article belongs to the Special Issue New Strategies in Cancer Pharmacotherapy: Development of Hormonal Antineoplastic Drugs, Cytotoxic Drugs and Targeted Therapies)
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Abstract

Targeting tumor cell motility and proliferation is an extremely important challenge in the prevention of metastasis and improving the effectiveness of cancer treatment. We recently published data revealing that DMU-214, the metabolite of firmly cytotoxic resveratrol analogue DMU-212, exerted significantly higher biological activity than the parent compound in ovarian cancer cells. The aim of the present study was to assess the molecular mechanism of the potential anti-migration and anti-proliferative effect of DMU-214 in ovarian cancer cell line SKOV-3. We showed that DMU-214 reduced the migratory capacity of SKOV-3 cells. The microarray analysis indicated ontology groups of genes involved in processes of negative regulation of cell motility and proliferation. Furthermore, we found DMU-214 triggered changes in expression of several migration- and proliferation-related genes (SMAD7, THBS1, IGFBP3, KLF4, Il6, ILA, SOX4, IL15, SRF, RGCC, GPR56) and proteins (GPR56, RGCC, SRF, SMAD7, THBS1), which have been shown to interact to each other to reduce cell proliferation and motility. Our study showed for the first time that DMU-214 displayed anti-migratory and anti-proliferative activity in SKOV-3 ovarian cancer cells. On the basis of whole transcriptome analysis of these cells, we provide new insight into the role of DMU-214 in inhibition of processes related to metastasis. View Full-Text
Keywords: resveratrol analogue; DMU-214; migration; proliferation; ovarian cancer resveratrol analogue; DMU-214; migration; proliferation; ovarian cancer
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MDPI and ACS Style

Nowicki, A.; Skupin-Mrugalska, P.; Jozkowiak, M.; Wierzchowski, M.; Rucinski, M.; Ramlau, P.; Krajka-Kuzniak, V.; Jodynis-Liebert, J.; Piotrowska-Kempisty, H. The Effect of 3′-Hydroxy-3,4,5,4′-Tetramethoxy -stilbene, the Metabolite of the Resveratrol Analogue DMU-212, on the Motility and Proliferation of Ovarian Cancer Cells. Int. J. Mol. Sci. 2020, 21, 1100. https://doi.org/10.3390/ijms21031100

AMA Style

Nowicki A, Skupin-Mrugalska P, Jozkowiak M, Wierzchowski M, Rucinski M, Ramlau P, Krajka-Kuzniak V, Jodynis-Liebert J, Piotrowska-Kempisty H. The Effect of 3′-Hydroxy-3,4,5,4′-Tetramethoxy -stilbene, the Metabolite of the Resveratrol Analogue DMU-212, on the Motility and Proliferation of Ovarian Cancer Cells. International Journal of Molecular Sciences. 2020; 21(3):1100. https://doi.org/10.3390/ijms21031100

Chicago/Turabian Style

Nowicki, Andrzej, Paulina Skupin-Mrugalska, Malgorzata Jozkowiak, Marcin Wierzchowski, Marcin Rucinski, Piotr Ramlau, Violetta Krajka-Kuzniak, Jadwiga Jodynis-Liebert, and Hanna Piotrowska-Kempisty. 2020. "The Effect of 3′-Hydroxy-3,4,5,4′-Tetramethoxy -stilbene, the Metabolite of the Resveratrol Analogue DMU-212, on the Motility and Proliferation of Ovarian Cancer Cells" International Journal of Molecular Sciences 21, no. 3: 1100. https://doi.org/10.3390/ijms21031100

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