New Strategies in Cancer Pharmacotherapy: Development of Hormonal Antineoplastic Drugs, Cytotoxic Drugs and Targeted Therapies

Dear Colleagues,

Cancer is a group of diseases characterized by abnormal growth and proliferation of cells which, in most cases, forms a tumor. Primary tumor growth is often accompanied by angiogenesis, progression, and metastasis. Some cancers are hormone-independent, whilst others are responsive to hormones (principally, sexual hormones in breast, prostate, and ovary cancers). For both hormone-dependent and independent cancers, the effectiveness of cytotoxic drugs is limited, and their use is often accompanied by severe adverse effects, leading to the continuous search for “next-generation” compounds and/or delivery strategies. Over the past two decades, great effort has been made to develop new effective therapies. In the case of hormone-dependent cancers, hormone antagonists, inhibitors, and analogues are currently used. In addition, emerging knowledge about the molecular mechanisms involved in the generation and progression of tumors has led to the design of promising therapies against specific molecular targets. The combination of hormonal analogues, classic or new-generation cytotoxic drugs, and targeted therapies (small RNAs, monoclonal antibodies) with new forms of drug delivery will hopefully have future successful application in cancer treatment.

This Special Issue “New strategies in cancer pharmacotherapy: Development of hormonal antineoplastic drugs, cytotoxic drugs and targeted therapies” will include reviews and original research on advances in cancer treatment. Novel insights into the development and assay of new compounds either alone or in combination are of particular interest for this issue.

Dr. Carlos Martínez-Campa
Dr. Carolina Alonso-González
Guest Editors

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