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International Journal of Molecular Sciences, Volume 21, Issue 20

October-2 2020 - 377 articles

Cover Story: New hybrid γ/γ-peptides, consisting of a cyclobutane-containing amino acid joined in alternation to a cis- or trans-γ-amino-L-proline decorated with guanidinium groups, have been synthesized and evaluated both as cell-penetrating peptides and as selective drug delivery vectors on Leishmania. While they lacked cytotoxicity on the tumoral human cell line HeLa, the tetradecamers were active on the protozoan parasite Leishmania with significant intracellular accumulation. Their conjugates with doxorubicin (Dox) improved the leishmanicidal effect of the free drug. Through molecular dynamics, the Dox moiety becomes wrapped by the peptide chain to be secluded from the aqueous environment, while the solubility of this payload increases by the exposed guanidinium groups at the periphery of the conjugate. View this paper
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Articles (377)

  • Article
  • Open Access
12 Citations
3,834 Views
23 Pages

21 October 2020

Crop reproduction is highly sensitive to water deficit and heat stress. The molecular networks of stress adaptation and grain development in tetraploid wheat (Triticum turgidum durum) are not well understood. Small RNAs (sRNAs) are important epigenet...

  • Review
  • Open Access
51 Citations
12,256 Views
18 Pages

Regulatory Connections between Iron and Glucose Metabolism

  • Carine Fillebeen,
  • Nhat Hung Lam,
  • Samantha Chow,
  • Amy Botta,
  • Gary Sweeney and
  • Kostas Pantopoulos

21 October 2020

Iron is essential for energy metabolism, and states of iron deficiency or excess are detrimental for organisms and cells. Therefore, iron and carbohydrate metabolism are tightly regulated. Serum iron and glucose levels are subjected to hormonal regul...

  • Review
  • Open Access
57 Citations
6,843 Views
20 Pages

21 October 2020

Oxidative stress induces various cardiovascular, neurodegenerative, and cancer diseases, caused by excess reactive oxygen species (ROS). It is attributed to the lack of sufficient antioxidant defense capacity to eliminate unnecessary ROS. Seaweeds ar...

  • Article
  • Open Access
29 Citations
4,380 Views
24 Pages

Quantitative Analysis of the Specific Absorption Rate Dependence on the Magnetic Field Strength in ZnxFe3−xO4 Nanoparticles

  • Mohamed Alae Ait Kerroum,
  • Cristian Iacovita,
  • Walid Baaziz,
  • Dris Ihiawakrim,
  • Guillaume Rogez,
  • Mohammed Benaissa,
  • Constantin Mihai Lucaciu and
  • Ovidiu Ersen

21 October 2020

Superparamagnetic ZnxFe3−xO4 magnetic nanoparticles (0 ≤ x < 0.5) with spherical shapes of 16 nm average diameter and different zinc doping level have been successfully synthesized by co-precipitation method. The homogeneous zinc substitu...

  • Review
  • Open Access
785 Citations
49,423 Views
29 Pages

21 October 2020

Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin receptor kinase B (TrkB) and the low affinity p75 neurotrophin receptor (p75NTR)...

  • Article
  • Open Access
11 Citations
6,085 Views
16 Pages

Molecular Analysis of Fetal and Adult Primary Human Liver Sinusoidal Endothelial Cells: A Comparison to Other Endothelial Cells

  • Muhammad Ahmer Jamil,
  • Heike Singer,
  • Rawya Al-Rifai,
  • Nicole Nüsgen,
  • Melanie Rath,
  • Sascha Strauss,
  • Ioanna Andreou,
  • Johannes Oldenburg and
  • Osman El-Maarri

21 October 2020

In humans, Factor VIII (F8) deficiency leads to hemophilia A and F8 is largely synthesized and secreted by the liver sinusoidal endothelial cells (LSECs). However, the specificity and characteristics of these cells in comparison to other endothelial...

  • Article
  • Open Access
73 Citations
5,617 Views
19 Pages

The bZIP Transcription Factor GmbZIP15 Negatively Regulates Salt- and Drought-Stress Responses in Soybean

  • Man Zhang,
  • Yanhui Liu,
  • Hanyang Cai,
  • Mingliang Guo,
  • Mengnan Chai,
  • Zeyuan She,
  • Li Ye,
  • Yan Cheng,
  • Bingrui Wang and
  • Yuan Qin

21 October 2020

Soybean (Glycine max), as an important oilseed crop, is constantly threatened by abiotic stress, including that caused by salinity and drought. bZIP transcription factors (TFs) are one of the largest TF families and have been shown to be associated w...

  • Article
  • Open Access
56 Citations
8,845 Views
16 Pages

21 October 2020

Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor 2 (VEGFR2) play an important role in cancer growth. Both of them have close relationships. Expression of EGFR will induce an angiogenic factor (VEGF) release for...

  • Article
  • Open Access
24 Citations
6,364 Views
12 Pages

Fasting Drives Nrf2-Related Antioxidant Response in Skeletal Muscle

  • Daniele Lettieri-Barbato,
  • Giuseppina Minopoli,
  • Rocco Caggiano,
  • Rossella Izzo,
  • Mariarosaria Santillo,
  • Katia Aquilano and
  • Raffaella Faraonio

21 October 2020

A common metabolic condition for living organisms is starvation/fasting, a state that could play systemic-beneficial roles. Complex adaptive responses are activated during fasting to help the organism to maintain energy homeostasis and avoid nutrient...

  • Article
  • Open Access
11 Citations
3,961 Views
18 Pages

Programmed Cell Death in the Left and Right Ventricle of the Late Phase of Post-Infarction Heart Failure

  • Martin Lichý,
  • Adrián Szobi,
  • Jaroslav Hrdlička,
  • Jan Neckář,
  • František Kolář and
  • Adriana Adameová

21 October 2020

While necroptosis has been shown to contribute to the pathogenesis of post-infarction heart failure (HF), the role of autophagy remains unclear. Likewise, linkage between these two cell death modalities has not been sufficiently investigated. HF was...

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Int. J. Mol. Sci. - ISSN 1422-0067