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Open AccessReview

Insights on the Interplay between Cells Metabolism and Signaling: A Therapeutic Perspective in Pediatric Acute Leukemias

1
Pediatric Hematology and Oncology Unit, S.Orsola-Malpighi Hospital, University of Bologna, 40126 Bologna, Italy
2
Pediatric Hematology-Oncology Unit, Department of Medical and Surgical Sciences DIMEC, University of Bologna, 40126 Bologna, Italy
3
Giorgio Prodi Interdepartmental Cancer Research Centre, University of Bologna, 40126 Bologna, Italy
*
Author to whom correspondence should be addressed.
These authors contribute equally to this work.
These authors contribute equally to this work.
Int. J. Mol. Sci. 2020, 21(17), 6251; https://doi.org/10.3390/ijms21176251
Received: 23 July 2020 / Revised: 20 August 2020 / Accepted: 22 August 2020 / Published: 28 August 2020
Nowadays, thanks to extensive studies and progress in precision medicine, pediatric leukemia has reached an extremely high overall survival rate. Nonetheless, a fraction of relapses and refractory cases is still present, which are frequently correlated with poor prognosis. Although several molecular features of these diseases are known, still the field of energy metabolism, which is widely studied in adult, has not been frequently explored in childhood leukemias. Metabolic reprogramming is a hallmark of cancer and is deeply connected with other genetic and signaling aberrations generally known to be key features of both acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). This review aims to clear the current knowledge on metabolic rewiring in pediatric ALL and AML, also highlighting the influence of the main signaling pathways and suggesting potential ideas to further exploit this field to discover new prognostic biomarkers and, above all, beneficial therapeutic options. View Full-Text
Keywords: metabolism/metabolomics; leukemia; pediatric tumors; molecular approaches; signal transduction inhibitors metabolism/metabolomics; leukemia; pediatric tumors; molecular approaches; signal transduction inhibitors
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Anselmi, L.; Bertuccio, S.N.; Lonetti, A.; Prete, A.; Masetti, R.; Pession, A. Insights on the Interplay between Cells Metabolism and Signaling: A Therapeutic Perspective in Pediatric Acute Leukemias. Int. J. Mol. Sci. 2020, 21, 6251.

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