Preimplantation Genetic Testing: Where We Are Today
1
Reproductive Medicine, Villa Mafalda, 00199 Rome, Italy
2
UniCamillus, International Medical University, 00131 Rome, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(12), 4381; https://doi.org/10.3390/ijms21124381
Received: 18 May 2020 / Revised: 13 June 2020 / Accepted: 16 June 2020 / Published: 19 June 2020
(This article belongs to the Special Issue Embryo Implantation and Placental Development)
Background: Preimplantation genetic testing (PGT) is widely used today in in-vitro fertilization (IVF) centers over the world for selecting euploid embryos for transfer and to improve clinical outcomes in terms of embryo implantation, clinical pregnancy, and live birth rates. Methods: We report the current knowledge concerning these procedures and the results from different clinical indications in which PGT is commonly applied. Results: This paper illustrates different molecular techniques used for this purpose and the clinical significance of the different oocyte and embryo stage (polar bodies, cleavage embryo, and blastocyst) at which it is possible to perform sampling biopsies for PGT. Finally, genetic origin and clinical significance of embryo mosaicism are illustrated. Conclusions: The preimplantation genetic testing is a valid technique to evaluated embryo euploidy and mosaicism before transfer.
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Keywords:
preimplantation genetic screening; in-vitro fertilization; biopsy; euploid embryo; implantation; pregnancy; endometrium; mosaicism
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MDPI and ACS Style
Greco, E.; Litwicka, K.; Minasi, M.G.; Cursio, E.; Greco, P.F.; Barillari, P. Preimplantation Genetic Testing: Where We Are Today. Int. J. Mol. Sci. 2020, 21, 4381.
AMA Style
Greco E, Litwicka K, Minasi MG, Cursio E, Greco PF, Barillari P. Preimplantation Genetic Testing: Where We Are Today. International Journal of Molecular Sciences. 2020; 21(12):4381.
Chicago/Turabian StyleGreco, Ermanno; Litwicka, Katarzyna; Minasi, Maria G.; Cursio, Elisabetta; Greco, Pier F.; Barillari, Paolo. 2020. "Preimplantation Genetic Testing: Where We Are Today" Int. J. Mol. Sci. 21, no. 12: 4381.
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