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International Journal of Molecular Sciences
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International Journal of Molecular Sciences, Volume 20, Issue 2

January-2 2019 - 224 articles

Cover Story: Phytohormones are natural chemical messengers that play critical roles in the regulation of plant growth and development as well as in responses to biotic and abiotic stress factors. The discovery, almost 40 years ago, of a new class of phytohormones, the brassinosteroids (BRs), opened a new era and introduced new perspectives in the regulation of agronomic traits through their use in agriculture. The present article provides an overview of BRs’ discovery and recent findings on their interactions with other phytohormones, in addition to clarifying how their network works to modulate plant growth, development, and responses to biotic and abiotic stresses. View this paper.
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Articles (224)

  • Article
  • Open Access
169 Citations
15,343 Views
18 Pages
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Gut Microbiota and Predicted Metabolic Pathways in a Sample of Mexican Women Affected by Obesity and Obesity Plus Metabolic Syndrome

  • Alejandra Chávez-Carbajal,
  • Khemlal Nirmalkar,
  • Ana Pérez-Lizaur,
  • Fernando Hernández-Quiroz,
  • Silvia Ramírez-del-Alto,
  • Jaime García-Mena and
  • César Hernández-Guerrero
Int. J. Mol. Sci.2019, 20(2), 438;https://doi.org/10.3390/ijms20020438

21 January 2019

Obesity is an excessive fat accumulation that could lead to complications like metabolic syndrome. There are reports on gut microbiota and metabolic syndrome in relation to dietary, host genetics, and other environmental factors; however, it is neces...

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  • Article
  • Open Access
33 Citations
5,556 Views
16 Pages
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Antibacterial Composites of Cuprous Oxide Nanoparticles and Polyethylene

  • Yanna Gurianov,
  • Faina Nakonechny,
  • Yael Albo and
  • Marina Nisnevitch
Int. J. Mol. Sci.2019, 20(2), 439;https://doi.org/10.3390/ijms20020439

21 January 2019

Cuprous oxide nanoparticles (Cu2ONPs) were used for preparing composites with linear low-density polyethylene (LLDPE) by co-extrusion, thermal adhesion, and attachment using ethyl cyanoacrylate, trimethoxyvinylsilane, and epoxy resin. The composites...

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  • Review
  • Open Access
7 Citations
6,413 Views
12 Pages
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Structure and Mechanism of the Divalent Anion/Na+ Symporter

  • Min Lu
Int. J. Mol. Sci.2019, 20(2), 440;https://doi.org/10.3390/ijms20020440

21 January 2019

Integral membrane proteins of the divalent anion/Na+ symporter (DASS) family are conserved from bacteria to humans. DASS proteins typically mediate the coupled uptake of Na+ ions and dicarboxylate, tricarboxylate, or sulfate. Since the substrates for...

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  • Article
  • Open Access
28 Citations
5,977 Views
24 Pages
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Exploration of the Effect of Blue Light on Functional Metabolite Accumulation in Longan Embryonic Calli via RNA Sequencing

  • Hansheng Li,
  • Yumeng Lyu,
  • Xiaohui Chen,
  • Congqiao Wang,
  • Deheng Yao,
  • Shanshan Ni,
  • Yuling Lin,
  • Yukun Chen,
  • Zihao Zhang and
  • Zhongxiong Lai
Int. J. Mol. Sci.2019, 20(2), 441;https://doi.org/10.3390/ijms20020441

21 January 2019

Light is an important factor that affects the synthesis of functional metabolites in longan embryogenic calli (ECs). However, analysis of the effect of light on functional metabolites in longan ECs via RNA sequencing has rarely been reported and thei...

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  • Review
  • Open Access
42 Citations
9,598 Views
23 Pages
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Arf GAPs as Regulators of the Actin Cytoskeleton—An Update

  • Christine E. Tanna,
  • Louisa B. Goss,
  • Calvin G. Ludwig and
  • Pei-Wen Chen
Int. J. Mol. Sci.2019, 20(2), 442;https://doi.org/10.3390/ijms20020442

21 January 2019

Arf GTPase-activating proteins (Arf GAPs) control the activity of ADP-ribosylation factors (Arfs) by inducing GTP hydrolysis and participate in a diverse array of cellular functions both through mechanisms that are dependent on and independent of the...

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  • Article
  • Open Access
20 Citations
7,492 Views
18 Pages
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Recurrent Stimulation of Natural Killer Cell Clones with K562 Expressing Membrane-Bound Interleukin-21 Affects Their Phenotype, Interferon-γ Production, and Lifespan

  • Maria A. Streltsova,
  • Sofya A. Erokhina,
  • Leonid M. Kanevskiy,
  • Maria V. Grechikhina,
  • Polina A. Kobyzeva,
  • Dean A. Lee,
  • William G. Telford,
  • Alexander M. Sapozhnikov and
  • Elena I. Kovalenko
Int. J. Mol. Sci.2019, 20(2), 443;https://doi.org/10.3390/ijms20020443

21 January 2019

A pattern of natural killer cell (NK cell) heterogeneity determines proliferative and functional responses to activating stimuli in individuals. Obtaining the progeny of a single cell by cloning the original population is one of the ways to study NK...

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  • Review
  • Open Access
71 Citations
13,554 Views
25 Pages
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Clinical Use and Molecular Action of Corticosteroids in the Pediatric Age

  • Giovanna Ferrara,
  • Maria Grazia Petrillo,
  • Teresa Giani,
  • Edoardo Marrani,
  • Cesare Filippeschi,
  • Teresa Oranges,
  • Gabriele Simonini and
  • Rolando Cimaz
Int. J. Mol. Sci.2019, 20(2), 444;https://doi.org/10.3390/ijms20020444

21 January 2019

Corticosteroids are the mainstay of therapy for many pediatric disorders and sometimes are life-saving. Both endogenous and synthetic derivatives diffuse across the cell membrane and, by binding to their cognate glucocorticoid receptor, modulate a va...

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  • Article
  • Open Access
24 Citations
6,111 Views
16 Pages
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Analysis of Mucopolysaccharidosis Type VI through Integrative Functional Metabolomics

  • Abdellah Tebani,
  • Lenaig Abily-Donval,
  • Isabelle Schmitz-Afonso,
  • Monique Piraud,
  • Jérôme Ausseil,
  • Farid Zerimech,
  • Carine Pilon,
  • Tony Pereira,
  • Stéphane Marret and
  • Carlos Afonso
  • + 1 author
Int. J. Mol. Sci.2019, 20(2), 446;https://doi.org/10.3390/ijms20020446

21 January 2019

Metabolic phenotyping is poised as a powerful and promising tool for biomarker discovery in inherited metabolic diseases. However, few studies applied this approach to mcopolysaccharidoses (MPS). Thus, this innovative functional approach may unveil c...

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  • Article
  • Open Access
48 Citations
11,940 Views
13 Pages
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Obstructive Sleep Apnea Activates HIF-1 in a Hypoxia Dose-Dependent Manner in HCT116 Colorectal Carcinoma Cells

  • Chloe-Anne Martinez,
  • Bernadette Kerr,
  • Charley Jin,
  • Peter A. Cistulli and
  • Kristina M. Cook
Int. J. Mol. Sci.2019, 20(2), 445;https://doi.org/10.3390/ijms20020445

21 January 2019

Obstructive sleep apnea (OSA) affects a significant proportion of the population and is linked to increased rates of cancer development and a worse cancer outcome. OSA is characterized by nocturnal intermittent hypoxia and animal models of OSA-like i...

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  • Article
  • Open Access
17 Citations
5,935 Views
17 Pages
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The Expression of Thrombospondin-4 Correlates with Disease Severity in Osteoarthritic Knee Cartilage

  • Kathrin Maly,
  • Inna Schaible,
  • Jana Riegger,
  • Rolf E. Brenner,
  • Andrea Meurer and
  • Frank Zaucke
Int. J. Mol. Sci.2019, 20(2), 447;https://doi.org/10.3390/ijms20020447

21 January 2019

Osteoarthritis (OA) is a progressive joint disease characterized by a continuous degradation of the cartilage extracellular matrix (ECM). The expression of the extracellular glycoprotein thrombospondin-4 (TSP-4) is known to be increased in injured ti...

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