Table of Contents
Int. J. Mol. Sci., Volume 20, Issue 11 (June-1 2019)
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Cover Story (view full-size image) The cynaroside luteolin-7-O-β-d-glucoside (LUT-7G) is able to induce keratinocyte differentiation [...] Read more. The cynaroside luteolin-7-O-β-d-glucoside (LUT-7G) is able to induce keratinocyte differentiation and inhibit the proliferative effects of the IL-22/IL6 pathway in vivo in a psoriatic mouse model. Now we know that LUT-7G blocks the cell energy metabolism, depressing the glycolytic and Krebs pathways by the direct inhibition of hexokinase 2 (HEK2) activity. LUT-7G is proposed as a potential candidate for the treatment of inflammatory and proliferative diseases, and its role in HEK2 inhibition opens new perspectives in nutrition and in cancer therapy for the potential inhibition of the Warburg effect. View this paper.