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Open AccessReview

The Role of Epigenetics in Placental Development and the Etiology of Preeclampsia

Institut Cochin, U1016 INSERM, UMR8104 CNRS, Université Paris Descartes, 24 rue du faubourg St Jacques, 75014 Paris, France
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(11), 2837; https://doi.org/10.3390/ijms20112837
Received: 3 May 2019 / Revised: 3 June 2019 / Accepted: 3 June 2019 / Published: 11 June 2019
(This article belongs to the Special Issue Molecular and Cellular Mechanisms of Preeclampsia)
In this review, we comprehensively present the function of epigenetic regulations in normal placental development as well as in a prominent disease of placental origin, preeclampsia (PE). We describe current progress concerning the impact of DNA methylation, non-coding RNA (with a special emphasis on long non-coding RNA (lncRNA) and microRNA (miRNA)) and more marginally histone post-translational modifications, in the processes leading to normal and abnormal placental function. We also explore the potential use of epigenetic marks circulating in the maternal blood flow as putative biomarkers able to prognosticate the onset of PE, as well as classifying it according to its severity. The correlation between epigenetic marks and impacts on gene expression is systematically evaluated for the different epigenetic marks analyzed. View Full-Text
Keywords: preeclampsia; epigenetics; DNA methylation; non coding RNAs; miRNAs; histone post translational modifications; HOX genes; H19; miR-210 preeclampsia; epigenetics; DNA methylation; non coding RNAs; miRNAs; histone post translational modifications; HOX genes; H19; miR-210
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MDPI and ACS Style

Apicella, C.; Ruano, C.S.M.; Méhats, C.; Miralles, F.; Vaiman, D. The Role of Epigenetics in Placental Development and the Etiology of Preeclampsia. Int. J. Mol. Sci. 2019, 20, 2837.

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