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Programmed Cell Death-1 Receptor (PD-1)-Mediated Regulation of Innate Lymphoid Cells

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
Department of Haematology, University College London Hospitals NHS Trust, London NW1 2BU, UK
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(11), 2836;
Received: 30 April 2019 / Revised: 4 June 2019 / Accepted: 6 June 2019 / Published: 11 June 2019
(This article belongs to the Special Issue PD-L1, A Master Regulator of Immunity)
Programmed cell death-1 (PD-1) is a cell surface receptor that dampens adaptive immune responses. PD-1 is activated by the engagement of its ligands PDL-1 or PDL-2. This results in the inhibition of T cell proliferation, differentiation, cytokine secretion, and cytolytic function. Although a great deal is known about PD-1 mediated regulation of CD4+ and CD8+ T cells, its expression and function in innate lymphoid cells (ILCs) are yet to be fully deciphered. This review summarizes the role of PD-1 in (1) modulating ILC development, (2) ILC function, and (3) PD-1 signaling in ILC. Finally, we explore how PD-1 based immunotherapies may be beneficial in boosting ILC responses in cancer, infections, and other immune-related disorders. View Full-Text
Keywords: PD-1; ILC; PDL-1 PD-1; ILC; PDL-1
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MDPI and ACS Style

Mallett, G.; Laurence, A.; Amarnath, S. Programmed Cell Death-1 Receptor (PD-1)-Mediated Regulation of Innate Lymphoid Cells. Int. J. Mol. Sci. 2019, 20, 2836.

AMA Style

Mallett G, Laurence A, Amarnath S. Programmed Cell Death-1 Receptor (PD-1)-Mediated Regulation of Innate Lymphoid Cells. International Journal of Molecular Sciences. 2019; 20(11):2836.

Chicago/Turabian Style

Mallett, Grace, Arian Laurence, and Shoba Amarnath. 2019. "Programmed Cell Death-1 Receptor (PD-1)-Mediated Regulation of Innate Lymphoid Cells" International Journal of Molecular Sciences 20, no. 11: 2836.

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