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Programmed Cell Death-1 Receptor (PD-1)-Mediated Regulation of Innate Lymphoid Cells

1
Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
2
Department of Haematology, University College London Hospitals NHS Trust, London NW1 2BU, UK
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(11), 2836; https://doi.org/10.3390/ijms20112836
Received: 30 April 2019 / Revised: 4 June 2019 / Accepted: 6 June 2019 / Published: 11 June 2019
(This article belongs to the Special Issue PD-L1, A Master Regulator of Immunity)
Programmed cell death-1 (PD-1) is a cell surface receptor that dampens adaptive immune responses. PD-1 is activated by the engagement of its ligands PDL-1 or PDL-2. This results in the inhibition of T cell proliferation, differentiation, cytokine secretion, and cytolytic function. Although a great deal is known about PD-1 mediated regulation of CD4+ and CD8+ T cells, its expression and function in innate lymphoid cells (ILCs) are yet to be fully deciphered. This review summarizes the role of PD-1 in (1) modulating ILC development, (2) ILC function, and (3) PD-1 signaling in ILC. Finally, we explore how PD-1 based immunotherapies may be beneficial in boosting ILC responses in cancer, infections, and other immune-related disorders. View Full-Text
Keywords: PD-1; ILC; PDL-1 PD-1; ILC; PDL-1
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MDPI and ACS Style

Mallett, G.; Laurence, A.; Amarnath, S. Programmed Cell Death-1 Receptor (PD-1)-Mediated Regulation of Innate Lymphoid Cells. Int. J. Mol. Sci. 2019, 20, 2836.

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