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Inhibitory Effect of Opuntia humifusa Fruit Water Extract on Solar Ultraviolet-Induced MMP-1 Expression

1
Traditional Food Research Group, Korea Food Research Institute, Wanju-gun 55365, Jeollabuk-do, Korea
2
Department of Food Science and Technology, Division of Applied Life Sciences (BK21 plus), and Institute of Agriculture and Life Science, Gyeongsang National University, Jinju-si 52828, Gyeongsangnam-do, Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(9), 2503; https://doi.org/10.3390/ijms19092503
Received: 6 July 2018 / Revised: 18 August 2018 / Accepted: 20 August 2018 / Published: 24 August 2018
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract

Opuntia humifusa is a type of cactus whose fruits have been used in folk medicine for the treatment of several diseases. In the present study, we aimed to determine whether O. humifusa fruit water extract (OHE) has inhibitory effects against solar ultraviolet (sUV)-induced matrix metalloproteinase-1 (MMP-1) expression. In ex vivo human skin, we found that OHE suppressed sUV radiation-induced MMP-1 expression. The inhibitory effect of OHE was confirmed in human dermal fibroblasts. OHE treatment reduced sUV-induced MMP-1 expression by suppressing reactive oxygen species (ROS) generation and phosphorylation of c-Jun, a component of transcription factor activator protein 1 (AP-1). On the other hand, OHE recovered the tissue inhibitor of matrix metalloproteinase 1 (TIMP-1) and type 1 collagen production attenuated by sUV. As upstream signaling pathways for AP-1, MKK4-JNK, MEK-ERK, and MKK3/6-p38 phosphorylation were downregulated by OHE treatment. In addition, OHE exhibited DPPH radical scavenging activity. These findings demonstrate that OHE has a preventive effect against sUV-induced skin damage via suppression of pathways triggered by ROS. View Full-Text
Keywords: Opuntia humifusa; sUV damage; ROS; MMP-1; photoaging Opuntia humifusa; sUV damage; ROS; MMP-1; photoaging
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Han, A.-R.; Lim, T.-G.; Song, Y.-R.; Jang, M.; Rhee, Y.K.; Hong, H.-D.; Kim, M.-H.; Kim, H.-J.; Cho, C.-W. Inhibitory Effect of Opuntia humifusa Fruit Water Extract on Solar Ultraviolet-Induced MMP-1 Expression. Int. J. Mol. Sci. 2018, 19, 2503.

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