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Molecules, Volume 26, Issue 16

August-2 2021 - 405 articles

Cover Story: DNA origami nanostructures are frequently employed as substrates for the single-molecule investigation of biomolecular reactions by in situ atomic force microscopy. This requires their immobilization at atomically flat surfaces such as mica, which is typically achieved by addition of millimolar concentrations of Mg2+ ions. These non-physiological Mg2+ concentrations, however, may interfere with the reactions and processes under investigation. Therefore, in this article, different strategies for efficient DNA origami immobilization at mica surfaces under essentially Mg2+-free conditions have been evaluated. Pre-adsorption of polycations such as spermidine has been identified as a particularly promising strategy, the efficiency of which, however, depends on the employed solution conditions and the DNA origami shape. View this paper.
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Articles (405)

  • Article
  • Open Access
8 Citations
7,403 Views
23 Pages

Synthesis, In Silico and In Vitro Evaluation of Antimicrobial and Toxicity Features of New 4-[(4-Chlorophenyl)sulfonyl]benzoic Acid Derivatives

  • Theodora-Venera Apostol,
  • Mariana Carmen Chifiriuc,
  • Constantin Draghici,
  • Laura-Ileana Socea,
  • Luminita Gabriela Marutescu,
  • Octavian Tudorel Olaru,
  • George Mihai Nitulescu,
  • Elena Mihaela Pahontu,
  • Gabriel Saramet and
  • Stefania-Felicia Barbuceanu

23 August 2021

The multi-step synthesis, physico-chemical characterization, and biological activity of novel valine-derived compounds, i.e., N-acyl-α-amino acids, 1,3-oxazol-5(4H)-ones, N-acyl-α-amino ketones, and 1,3-oxazoles derivatives, bearing a 4-[(4-chlorophe...

  • Article
  • Open Access
29 Citations
4,671 Views
15 Pages

Assessment of Volatile Aromatic Compounds in Smoke Tainted Cabernet Sauvignon Wines Using a Low-Cost E-Nose and Machine Learning Modelling

  • Vasiliki Summerson,
  • Claudia Gonzalez Viejo,
  • Alexis Pang,
  • Damir D. Torrico and
  • Sigfredo Fuentes

23 August 2021

Wine aroma is an important quality trait in wine, influenced by its volatile compounds. Many factors can affect the composition and levels (concentration) of volatile aromatic compounds, including the water status of grapevines, canopy management, an...

  • Article
  • Open Access
10 Citations
3,154 Views
15 Pages

Specificity and Origin of the Stability of the Sr Isotopic Ratio in Champagne Wines

  • Robin Cellier,
  • Sylvain Bérail,
  • Julien Barre,
  • Ekaterina Epova,
  • Anne-Laure Ronzani,
  • Cornelis Van Leeuwen,
  • Stanislas Milcent,
  • Patrick Ors and
  • Olivier F. X. Donard

23 August 2021

The 87Sr/86Sr ratio of 39 Champagnes from six different brands, originating from the whole “Appellation d’Origine Contrôlée” (AOC) Champagne was analyzed to establish a possible relation with the geographical origin. Musts (i.e., grape juice) and bas...

  • Review
  • Open Access
14 Citations
6,459 Views
25 Pages

23 August 2021

There is an urgent need to find new antibacterial agents to combat bacterial infections, including agents that inhibit novel, hitherto unexploited targets in bacterial cells. Amongst novel targets are two-component signal transduction systems (TCSs)...

  • Review
  • Open Access
43 Citations
7,143 Views
20 Pages

23 August 2021

There are tens of thousands of scientific papers about flavonoids and their impacts on human health. However, despite the vast amount of energy that has been put toward studying these compounds, a unified molecular mechanism that explains their bioac...

  • Article
  • Open Access
7 Citations
3,254 Views
15 Pages

α,α-Difluorophosphonohydroxamic Acid Derivatives among the Best Antibacterial Fosmidomycin Analogues

  • Aurore Dreneau,
  • Fanny S. Krebs,
  • Mathilde Munier,
  • Chheng Ngov,
  • Denis Tritsch,
  • Didier Lièvremont,
  • Michel Rohmer and
  • Catherine Grosdemange-Billiard

23 August 2021

Three α,α-difluorophosphonate derivatives of fosmidomycin were synthesized from diethyl 1,1-difluorobut-3-enylphosphonate and were evaluated on Escherichia coli. Two of them are among the best 1-deoxy-d-xylulose 5-phosphate reductoisomerase inhibitor...

  • Article
  • Open Access
8 Citations
4,087 Views
15 Pages

Efficient Use of Carbon Fibers as Heating Elements for Curing of Epoxy Matrix Composites

  • Lykourgos C. Kontaxis,
  • Ioannis E. Chontzoglou and
  • George C. Papanicolaou

23 August 2021

The aim of this study is to achieve a fully cured thermoset matrix that is heated by a direct electric current passing through the reinforcement fibers i.e., the Joule heating effect. Two types of fibers were used as heating elements for curing the e...

  • Article
  • Open Access
24 Citations
4,396 Views
18 Pages

23 August 2021

Thymus vulgaris L. is one of the most commonly used medicinal and aromatic plants (MAPs), owing to a range of therapeutic properties of its essential oil. Plant growth, biomass yield, essential oil content and composition are influenced by chemotype,...

  • Article
  • Open Access
6 Citations
3,575 Views
10 Pages

Egg Case Protein 3: A Constituent of Black Widow Spider Tubuliform Silk

  • Mikayla Shanafelt,
  • Camille Larracas,
  • Simmone Dyrness,
  • Ryan Hekman,
  • Coby La Mattina-Hawkins,
  • Taylor Rabara,
  • Wilson Wu and
  • Craig A. Vierra

22 August 2021

Spider silk has outstanding mechanical properties, rivaling some of the best materials on the planet. Biochemical analyses of tubuliform silk have led to the identification of TuSp1, egg case protein 1, and egg case protein 2. TuSp1 belongs to the sp...

  • Article
  • Open Access
12 Citations
4,076 Views
16 Pages

Effect of Precursor Nature and Sol-Gel Synthesis Conditions on TiO2 Aerogel’s Structure

  • Jolanta Doneliene,
  • Egle Fataraite-Urboniene,
  • Matas Rudzikas,
  • Saulius Pakalka,
  • Nina Danchova and
  • Juras Ulbikas

22 August 2021

The aim of this investigation was to synthesize high porosity TiO2 aerogel by applying sol-gel and subcritical drying methods and to identify the influence of reagent’s nature and synthesis conditions on their structural and optical properties. Metho...

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Molecules - ISSN 1420-3049