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Molecules, Volume 26, Issue 16

August-2 2021 - 405 articles

Cover Story: DNA origami nanostructures are frequently employed as substrates for the single-molecule investigation of biomolecular reactions by in situ atomic force microscopy. This requires their immobilization at atomically flat surfaces such as mica, which is typically achieved by addition of millimolar concentrations of Mg2+ ions. These non-physiological Mg2+ concentrations, however, may interfere with the reactions and processes under investigation. Therefore, in this article, different strategies for efficient DNA origami immobilization at mica surfaces under essentially Mg2+-free conditions have been evaluated. Pre-adsorption of polycations such as spermidine has been identified as a particularly promising strategy, the efficiency of which, however, depends on the employed solution conditions and the DNA origami shape. View this paper.
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Articles (405)

  • Article
  • Open Access
5 Citations
4,491 Views
23 Pages

Acanthaster planci Inhibits PCSK9 and Lowers Cholesterol Levels in Rats

  • Nurjannatul Naim Kamaruddin,
  • Nor Azwin Hajri,
  • Yosie Andriani,
  • Aina Farahiyah Abdul Manan,
  • Tengku Sifzizul Tengku Muhammad and
  • Habsah Mohamad

23 August 2021

Atherosclerosis is the main cause of cardiovascular diseases which in turn, lead to the highest number of mortalities globally. This pathophysiological condition is developed due to a constant elevated level of plasma cholesterols. Statin is currentl...

  • Article
  • Open Access
8 Citations
4,073 Views
12 Pages

Development of Highly Sensitive Raman Spectroscopy for Subnano and Single-Atom Detection

  • Yuansen Tang,
  • Naoki Haruta,
  • Akiyoshi Kuzume and
  • Kimihisa Yamamoto

23 August 2021

Direct detection and characterisation of small materials are fundamental challenges in analytical chemistry. A particle composed of dozens of metallic atoms, a so-called subnano-particle (SNP), and a single-atom catalyst (SAC) are ultimate analysis t...

  • Article
  • Open Access
17 Citations
4,142 Views
25 Pages

Fungal α-1,3-Glucan as a New Pathogen-Associated Molecular Pattern in the Insect Model Host Galleria mellonella

  • Sylwia Stączek,
  • Agnieszka Zdybicka-Barabas,
  • Iwona Wojda,
  • Adrian Wiater,
  • Paweł Mak,
  • Piotr Suder,
  • Krzysztof Skrzypiec and
  • Małgorzata Cytryńska

23 August 2021

Recognition of pathogen-associated molecular patterns (PAMPs) by appropriate pattern recognition receptors (PRRs) is a key step in activating the host immune response. The role of a fungal PAMP is attributed to β-1,3-glucan. The role of α-1,3-glucan,...

  • Feature Paper
  • Article
  • Open Access
4 Citations
4,539 Views
11 Pages

Integratomics of Human Dermal Fibroblasts Treated with Low Molecular Weight Hyaluronic Acid

  • Silvia Radrezza,
  • Gilda Aiello,
  • Giovanna Baron,
  • Giancarlo Aldini,
  • Marina Carini and
  • Alfonsina D’Amato

23 August 2021

Hyaluronic acid (HA) is a glycosaminoglycan very common in commercial products from pharmaceuticals to cosmetics due to its widespread distribution in humans and its diversified physico-chemical proprieties. Despite its extended use and preliminary e...

  • Article
  • Open Access
6 Citations
3,531 Views
12 Pages

Guiding Molecularly Imprinted Polymer Design by Pharmacophore Modeling

  • Wiebke Derz,
  • Melita Fleischmann and
  • Paul W. Elsinghorst

23 August 2021

Molecularly imprinted polymers (MIP) combine the selectivity of immunoaffinity chromatography with the robustness of common solid-phase extraction in what is referred to as molecularly imprinted solid-phase extraction (MISPE). This contribution shows...

  • Article
  • Open Access
9 Citations
2,421 Views
13 Pages

Fluorescent Azasteroids through Ultrasound Assisted Cycloaddition Reactions

  • Costel Moldoveanu,
  • Ionel Mangalagiu and
  • Gheorghita Zbancioc

23 August 2021

We report here the synthesis and optical spectral properties of several new azasteroid derivatives. The formation of these compounds was explained based on the most probable mechanism. The luminescent heterocycles were synthesized by 1,3-dipolar cycl...

  • Article
  • Open Access
41 Citations
4,823 Views
19 Pages

Cancer Cell Membrane-Coated Nanosuspensions for Enhanced Chemotherapeutic Treatment of Glioma

  • Yueyue Fan,
  • Wenyan Hao,
  • Yuexin Cui,
  • Mengyu Chen,
  • Xiaoyang Chu,
  • Yang Yang,
  • Yuli Wang and
  • Chunsheng Gao

23 August 2021

Effective intracerebral delivery is key for glioma treatment. However, the drug delivery system within the brain is largely limited by its own adverse physical and chemical properties, low targeting efficiency, the blood–brain barrier and the blood–b...

  • Article
  • Open Access
52 Citations
4,333 Views
28 Pages

23 August 2021

In this work, different pretreatment methods for algae proved to be very effective in improving cell wall dissociation for biogas production. In this study, the Ulva intestinalis Linnaeus (U. intestinalis) has been exposed to individual pretreatments...

  • Feature Paper
  • Article
  • Open Access
18 Citations
3,756 Views
15 Pages

Donkey Milk Fermentation by Lactococcus lactis subsp. cremoris and Lactobacillus rhamnosus Affects the Antiviral and Antibacterial Milk Properties

  • Simona Cirrincione,
  • Anna Luganini,
  • Cristina Lamberti,
  • Marcello Manfredi,
  • Laura Cavallarin,
  • Maria Gabriella Giuffrida and
  • Enrica Pessione

23 August 2021

Background: Milk is considered an important source of bioactive peptides, which can be produced by endogenous or starter bacteria, such as lactic acid bacteria, that are considered effective and safe producers of food-grade bioactive peptides. Among...

  • Article
  • Open Access
14 Citations
3,793 Views
16 Pages

23 August 2021

In this study, time-dependent, one-dimensional modeling of a surface dielectric barrier discharge (SDBD) device, driven by a sinusoidal voltage of amplitude 1–3 kV at 20 kHz, in argon is described. An SDBD device with two Cu-stripe electrodes, covere...

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Molecules - ISSN 1420-3049