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Molecules
Volume 24
Issue 8
10.3390/molecules24081596
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Article

Anthocyanin Encapsulated by Ferulic Acid-Grafted-Maltodextrin (FA-g-MD) Microcapsules Potentially Improved its Free Radical Scavenging Capabilities Against H2O2-Induced Oxidative Stress

by
Yi Ma
1,*,†,
Yunhui Feng
2,†,
Wanling Zeng
1 and
Huibo Luo
1,*
1
College of Bioengineering, Sichuan University of Science and Engineering, Zigong 643000, China
2
Department of Physical Education, Guangzhou University, Guangzhou 510006, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Molecules 2019, 24(8), 1596; https://doi.org/10.3390/molecules24081596
Received: 12 March 2019 / Revised: 12 April 2019 / Accepted: 19 April 2019 / Published: 23 April 2019
(This article belongs to the Special Issue Anthocyanins: Recent Progress in Health Benefits Studies)
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Abstract

This study aimed to investigate the antioxidant activity and release behavior of anthocyanin (ANC) loaded within FA-g-MD wall (ANC-FA-g-MD microcapsule) in vitro. The microencapsulation of ANC was prepared by spray drying and displayed a biphasic release profile. The combination of ANC and FA-g-MD (0.0625–1 mg/mL) showed a higher antioxidant activity than that of both individuals. A possible intermolecular interaction between ANC and FA-g-MD was studied by UV-vis spectra. Intracellular reactive oxygen species (ROS), 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) test, and protein expression of quinone oxidoreductase 1(NQO1), glutathione reductase (GSR) and γ-glutamate cysteine ligase catalytic subunit (γ-GCLC) were measured through human colon cancer cells (HT-29). After a 24-hour incubation of the HT-29, the combinations (0–60 μg/mL) exhibited a high potential to diminish the ROS level. And the distinct upregulated expressions of GCLC and NQO1 of HT-29 were detected after treatment with combinations compared to those of single ones. These results suggested that the ANC-FA-g-MD microcapsules exerts enhanced antioxidant effect with capability of the modulation of GCLC and NQO1. View Full-Text
Keywords: antioxidant; oxidative stress; anthocyanin; HT-29 antioxidant; oxidative stress; anthocyanin; HT-29
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
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MDPI and ACS Style

Ma, Y.; Feng, Y.; Zeng, W.; Luo, H. Anthocyanin Encapsulated by Ferulic Acid-Grafted-Maltodextrin (FA-g-MD) Microcapsules Potentially Improved its Free Radical Scavenging Capabilities Against H2O2-Induced Oxidative Stress. Molecules 2019, 24, 1596. https://doi.org/10.3390/molecules24081596

AMA Style

Ma Y, Feng Y, Zeng W, Luo H. Anthocyanin Encapsulated by Ferulic Acid-Grafted-Maltodextrin (FA-g-MD) Microcapsules Potentially Improved its Free Radical Scavenging Capabilities Against H2O2-Induced Oxidative Stress. Molecules. 2019; 24(8):1596. https://doi.org/10.3390/molecules24081596

Chicago/Turabian Style

Ma, Yi, Yunhui Feng, Wanling Zeng, and Huibo Luo. 2019. "Anthocyanin Encapsulated by Ferulic Acid-Grafted-Maltodextrin (FA-g-MD) Microcapsules Potentially Improved its Free Radical Scavenging Capabilities Against H2O2-Induced Oxidative Stress" Molecules 24, no. 8: 1596. https://doi.org/10.3390/molecules24081596

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