Next Article in Journal
Indole Alkaloids from the Leaves of Nauclea officinalis
Next Article in Special Issue
Recent Advances in Metal-Free Quinoline Synthesis
Previous Article in Journal
Harnessing the Therapeutic Potential of Capsaicin and Its Analogues in Pain and Other Diseases
Previous Article in Special Issue
Synthesis of New 3-Heteroarylindoles as Potential Anticancer Agents
Open AccessArticle

Synthesis and Spectral Characterization of Benzo-[6,7][1,5]diazocino[2,1-a]isoindol-12-(14H)-one Derivatives

School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK
Authors to whom correspondence should be addressed.
Academic Editor: Philippe Belmont
Molecules 2016, 21(8), 967;
Received: 28 June 2016 / Revised: 19 July 2016 / Accepted: 20 July 2016 / Published: 23 July 2016
(This article belongs to the Collection Heterocyclic Compounds)
A simple synthetic route affording 27%–85% yields of benzo[6,7][1,5]diazocino[2,1-a]isoindol-12(14H)-one ring systems from readily available 3-(2-oxo-2-phenylethyl) isobenzofuran-1(3H)-ones and 2-(aminomethyl)aniline starting materials in toluene and catalysed by p-toluene-sulfonic acid is developed. The 1H- and 13C-NMR spectra of the final products were assigned using a variety of one and two-dimensional NMR experiments. The distinction between the two potential isomers of the final products was made on the basis of heteronuclear multiple bond connectivity (HMBC) NMR spectra. View Full-Text
Keywords: diazocine; isoindole; isobenzofuran-1(3H)-ones; 2D-NMR diazocine; isoindole; isobenzofuran-1(3H)-ones; 2D-NMR
Show Figures

Graphical abstract

MDPI and ACS Style

Bassin, J.P.; Anagani, B.; Benham, C.; Goyal, M.; Hashemian, M.; Gerhard, U. Synthesis and Spectral Characterization of Benzo-[6,7][1,5]diazocino[2,1-a]isoindol-12-(14H)-one Derivatives. Molecules 2016, 21, 967.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop