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Molecules 2016, 21(3), 336;

New Anti-HBV C-Boivinopyranosyl Flavones from Alternanthera philoxeroides

Department of Pharmaceutical Chemistry, Beijing Institute of Radiation Medicine, Beijing 100850, China
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Nancy D. Turner
Received: 19 January 2016 / Revised: 14 February 2016 / Accepted: 4 March 2016 / Published: 14 March 2016
(This article belongs to the Collection Bioactive Compounds)
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C-boivinopyranosyl flavones have rarely been isolated from nature. In the search for anti-HBV (hepatitis b virus) constituents of Alternanthera philoxeroides, two new compounds, luteolin-6-C-β-d-boivinopyranosyl-3′-O-β-d-glucopyranoside (1) and chrysoeriol-6-C-β-d-boivinopyranosyl-4′-O-β-d-glucopyranoside (2), along with three known C-boivinopyranosyl flavones (compounds 3–5) were isolated. Their structures were determined by spectroscopic analyses including 1D and 2D NMR, HR-ESI-MS, IR spectra. Compounds 1, 2 and 3 showed significant anti-HBV activities through specifically inhibiting the secretion of HBsAg in HepG2.2.15. View Full-Text
Keywords: C-boivinopyranosyl flavones; Alternanthera philoxeroides; anti-HBV activity C-boivinopyranosyl flavones; Alternanthera philoxeroides; anti-HBV activity

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Li, B.; Guo, Q.-L.; Tian, Y.; Liu, S.-J.; Wang, Q.; Chen, L.; Dong, J.-X. New Anti-HBV C-Boivinopyranosyl Flavones from Alternanthera philoxeroides. Molecules 2016, 21, 336.

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