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Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
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Molecules 2010, 15(12), 8689-8701; https://doi.org/10.3390/molecules15128689
Received: 6 November 2010 / Revised: 17 November 2010 / Accepted: 22 November 2010 / Published: 30 November 2010
A novel trifluoromethylated analogue of cADPR, 8-CF3-cIDPDE (5) was designed and synthesized via construction of N1,N9-disubstituted hypoxanthine, trifluoromethylation and intramolecular condensation. A series of acyclic analogues of cADPR were also designed and synthesized. These compounds could be useful molecules for studying the structure-activity relationship of cADPR analogues and exploring the cADPR/RyR Ca2+ signalling system. View Full-Text
Keywords: cADPR analogue; acyclic cADPR analogue; trifluoromethylation; synthesis cADPR analogue; acyclic cADPR analogue; trifluoromethylation; synthesis
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Huang, X.; Dong, M.; Liu, J.; Zhang, K.; Yang, Z.; Zhang, L.; Zhang, L. Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR. Molecules 2010, 15, 8689-8701.

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