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Keywords = acyclic cADPR analogue

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Article
Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR
by Xiangchen Huang, Min Dong, Jian Liu, Kehui Zhang, Zhenjun Yang, Liangren Zhang and Lihe Zhang
Molecules 2010, 15(12), 8689-8701; https://doi.org/10.3390/molecules15128689 - 30 Nov 2010
Cited by 15 | Viewed by 6485
Abstract
A novel trifluoromethylated analogue of cADPR, 8-CF3-cIDPDE (5) was designed and synthesized via construction of N1,N9-disubstituted hypoxanthine, trifluoromethylation and intramolecular condensation. A series of acyclic analogues of cADPR were also designed and synthesized. These compounds [...] Read more.
A novel trifluoromethylated analogue of cADPR, 8-CF3-cIDPDE (5) was designed and synthesized via construction of N1,N9-disubstituted hypoxanthine, trifluoromethylation and intramolecular condensation. A series of acyclic analogues of cADPR were also designed and synthesized. These compounds could be useful molecules for studying the structure-activity relationship of cADPR analogues and exploring the cADPR/RyR Ca2+ signalling system. Full article
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