Next Article in Journal
Bio-Ecological Features Update on Eleven Rare Cartilaginous Fish in the Central-Western Mediterranean Sea as a Contribution for Their Conservation
Previous Article in Journal
When SUV Matters: FDG PET/CT at Baseline Correlates with Survival in Soft Tissue and Ewing Sarcoma
 
 
Review

State-of-the-Art on Biomarkers for Anaphylaxis in Obstetrics

1
Department of Obstetrics and Gynecology Filantropia Clinical Hospital, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania
2
Department of Family Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania
3
Department of Allergology Clinical Hospital Nicolae Malaxa, Carol Davila University of Medicine and Pharmacy, 022441 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Academic Editors: Ilona Hromadnikova and Katerina Kotlabova
Life 2021, 11(9), 870; https://doi.org/10.3390/life11090870
Received: 29 July 2021 / Revised: 21 August 2021 / Accepted: 23 August 2021 / Published: 24 August 2021
(This article belongs to the Topic Pathogenesis of Pregnancy-Related Complications)
Anaphylaxis is an unpredictable systemic hypersensitivity reaction and constitutes a high risk of maternal and fetal morbidity and mortality when occurring during pregnancy. Currently, the acute management of anaphylaxis is based on clinical parameters. A total serum tryptase is only used to support an accurate diagnosis. There is a need to detect other biomarkers to further assess high-risk patients in obstetrics. Our objective is to present biomarkers in this complex interdisciplinary approach beyond obstetrician and anaesthetic management. Candidate biomarkers derive either from mediators involved in immunopathogenesis or upcoming molecules from systems biology and proteomics. Serum tryptase is determined by singleplex immunoassay method and is important in the evaluation of anaphylactic mast cell degranulation but also in the assessment of other risk factors for anaphylaxis such as systemic mastocytosis. Another category of biomarkers investigates the IgE-mediated sensitization to triggers potentially involved in the etiology of anaphylaxis in pregnant women, using singleplex or multiplex immunoassays. These in vitro tests with natural extracts from foods, venoms, latex or drugs, as well as with molecular allergen components, are useful because in vivo allergy tests cannot be performed on pregnant women in such a major medical emergency due to their additional potential risk of anaphylaxis. View Full-Text
Keywords: anaphylaxis; pregnancy; biomarkers; tryptase; in vitro allergy tests; immunoassays anaphylaxis; pregnancy; biomarkers; tryptase; in vitro allergy tests; immunoassays
Show Figures

Figure 1

MDPI and ACS Style

Simionescu, A.A.; Stanescu, A.M.A.; Popescu, F.-D. State-of-the-Art on Biomarkers for Anaphylaxis in Obstetrics. Life 2021, 11, 870. https://doi.org/10.3390/life11090870

AMA Style

Simionescu AA, Stanescu AMA, Popescu F-D. State-of-the-Art on Biomarkers for Anaphylaxis in Obstetrics. Life. 2021; 11(9):870. https://doi.org/10.3390/life11090870

Chicago/Turabian Style

Simionescu, Anca Angela, Ana Maria Alexandra Stanescu, and Florin-Dan Popescu. 2021. "State-of-the-Art on Biomarkers for Anaphylaxis in Obstetrics" Life 11, no. 9: 870. https://doi.org/10.3390/life11090870

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop