Molecular and Supramolecular Mechanosynthesis

Dear Colleagues,

Mechanochemistry is transforming the way we design and carry out chemical processes—harnessing mechanical force instead of heat or solvents to drive reactions with unprecedented efficiency, sustainability, and precision. From solvent-free organic syntheses and rapid metal–organic framework assembly to innovative polymer recycling and smart, force-responsive materials, this emergent field is unlocking greener pathways and breakthrough functionalities across catalysis, materials science, energy storage, and beyond. In this Topic, we shall focus on the forefront of mechanochemical discovery to share the latest insights, methodologies, and applications. Whether you are developing novel milling protocols, exploring mechanophore-activated systems, or advancing scale-up strategies, your contributions will help shape the next wave of sustainable, high-impact science. The scope of this Topic will consist of topical research, including (but not limited to) the following areas:

• Organic synthesis;
• Pharmaceutical cocrystals;
• Metal–Organic Frameworks
• Nanoparticle synthesis;
• Polymer synthesis;
• Composites;
• Catalysis.

Prof. Dr. Vasco D. B. Bonifácio
Dr. Clara B. Gomes
Dr. Rita F. Pires
Topic Editors