Emerging Perspectives on Protein Structure and Function

Dear Colleagues,

Proteins play a central role in nearly all biological processes, acting as enzymes, structural components, signaling molecules, and regulators of cellular activity. Understanding how protein structure determines function remains a fundamental goal in biophysics and molecular biology. Recent advances in experimental and computational methods now enable detailed exploration of protein architecture and dynamics at unprecedented resolution. 

This Special Issue of Biophysica focuses on recent progress in the structural and biophysical characterization of proteins and protein complexes. We welcome contributions employing diverse approaches, including X-ray crystallography, cryo-electron microscopy, NMR spectroscopy, molecular dynamics simulations, and AI-based structure prediction.

Topics of interest include protein folding and stability, conformational dynamics, enzyme mechanisms, protein–protein interactions, membrane proteins, and protein misfolding in disease. By integrating structural, biochemical, and computational perspectives, this Special Issue aims to advance our understanding of how protein structure governs biological function and supports the development of new therapeutic strategies. Through this collection, Biophysica seeks to promote interdisciplinary dialogue and showcase innovative approaches that illuminate the dynamic and complex nature of proteins in biological systems.

Dr. Rüdiger H. Ettrich
Guest Editor

Manuscript Submission Information

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