Research Updates in Vestibular Dysfunction: Diagnostic Breakthroughs

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 20 March 2026 | Viewed by 739

Special Issue Editors

Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, China
Interests: vertigo; vestibular diseases; vestibular compensation; hearing and balance; hearing loss; aging

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Guest Editor
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Interests: vertigo; vestibular diseases; vestibular compensation; hearing and balance; hearing loss; aging

Special Issue Information

Dear Colleagues,

Vestibular dysfunction, characterized by vertigo and postural instability, is prevalent among middle-aged and older adults, posing a heightened risk of falls and contributing to injury and disability. Despite its clinical significance, the development of precise diagnostic and therapeutic strategies remains hindered by gaps in understanding the molecular and cellular mechanisms underlying these disorders.

This Special Issue focuses on advances in molecular and pathological diagnostics for vestibular dysfunction, including the following:

  • Novel biomarkers (e.g., proteomic, genetic, and inflammatory markers) for early detection and subtype classification;
  • Emerging imaging and laboratory-based techniques (e.g., high-resolution vestibular testing, omics approaches) to improve diagnostic accuracy;
  • Mechanistic insights into vestibular disorders such as Meniere’s disease, BPPV, vestibular migraine, and PPPD, with a focus on translating research into clinical applications.

We welcome fundamental and clinical studies, as well as reviews, that explore cutting-edge diagnostic tools, biomarker discovery, and mechanistic research to bridge the gap between laboratory findings and patient care.

Dr. Jun Wang
Dr. Sulin Zhang
Guest Editors

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Keywords

  • vestibular disorders
  • vertigo
  • biomarkers
  • molecular diagnostics
  • vestibular compensation
  • Meniere’s disease
  • BPPV
  • vestibular migraine
  • PPPD
  • dizziness
  • balance

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Published Papers (1 paper)

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20 pages, 4846 KB  
Case Report
Diagnosis of Isolated Saccular Dysfunction Using Trapezius cVEMP: A Detailed Vestibular Assessment
by Mădălina Georgescu, Oana Irina Popa, Horațiu Ștefănescu, Violeta Necula, Alma Maniu, Irina Enache and Andrei Osman
Diagnostics 2025, 15(23), 2988; https://doi.org/10.3390/diagnostics15232988 - 25 Nov 2025
Viewed by 516
Abstract
Background and Clinical Significance: Vestibular disorders include a wide range of conditions with overlapping symptoms such as dizziness, vertigo and imbalance, often offering diagnostic challenges when distinguishing between peripheral and central etiology. Accurate differentiation is essential for establishing effective treatment plans. In [...] Read more.
Background and Clinical Significance: Vestibular disorders include a wide range of conditions with overlapping symptoms such as dizziness, vertigo and imbalance, often offering diagnostic challenges when distinguishing between peripheral and central etiology. Accurate differentiation is essential for establishing effective treatment plans. In rare or atypical cases with subtle findings, comprehensive diagnostic tools—such as extended vestibular tests and structured questionnaires like the Dizziness Handicap Inventory (DHI)—are critical for diagnosis and monitoring patient recovery. Case Presentation: A 35-year-old female presented with chronic imbalance and motion-induced dizziness persisting for four years. The patient had a surgical history of right-sided functional neck dissection for a parotid tumor. A comprehensive audiovestibular evaluation was performed, including pure tone audiometry (PTA), tympanometry, videonystagmography (VNG), cervical vestibular evoked myogenic potentials (cVEMP), ocular vestibular evoked myogenic potentials (oVEMP), video head impulse testing (vHIT), computerized dynamic posturography (CDP), and magnetic resonance imaging (MRI). The Dizziness Handicap Index (DHI) was administered at baseline and post-treatment to monitor subjective symptom changes. Objective testing revealed marked right–left amplitude asymmetry on cVEMP, which were recorded from the trapezius muscle due to prior neck dissection surgery, indicating isolated right-sided saccular hypofunction. Following targeted vestibular rehabilitation and pharmacologic treatment, the 3-month reassessment demonstrated resolution of symptoms and a reduction in DHI scores from 24 to 6. Conclusions: Comprehensive vestibular testing, performed in a single diagnostic session, enabled the accurate identification of isolated right-sided saccular hypofunction in this complex post-surgical case. Combining cVEMP, CDP, and DHI assessment provided a complete functional profile, guided targeted rehabilitation, and allowed objective monitoring of recovery. Full article
(This article belongs to the Special Issue Research Updates in Vestibular Dysfunction: Diagnostic Breakthroughs)
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