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Biophysica
Special Issues
Mechanobiology of Regeneration: From Physical Aspects
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Mechanobiology of Regeneration: From Physical Aspects

A Special Issue of Biophysica (ISSN 2673-4125).

Deadline for manuscript submissions: 25 January 2027 | Viewed by 1833

Editors

Dr. Christopher Robinson

E-Mail Website
Guest Editor
Department of Anesthesiology, Perioperative, and Pain Medicine, Harvard Medical School, Brigham and Women’s Hospital, Boston, MA 02115, USA
Interests: regenerative medicine; drug discovery; gene therapy; exosomes; proteomics; genomics; gene editing; CRISPR; stem cells; artificial intelligence; neuromodulation
Special Issues, Collections and Topics in MDPI journals
Dr. Alan David Kaye

E-Mail Website
Guest Editor
Department of Anesthesiology, Louisiana State University, Shreveport, LA, USA
Interests: pharmacology; anesthesiology; pain management; pain medicine; opioids
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We invite you to submit original research and review articles that address the physical principles underpinning regenerative biology to our Special Issue, “Mechanobiology of Regeneration: From Physical Aspects”. Mechanical forces, including tension, compression, shear stress, and substrate stiffness, are key regulators of cellular behavior and tissue regeneration. The focus of this issue is on how these physical cues are sensed, transmitted, and integrated at the cellular and tissue levels to guide repair and remodeling. We welcome contributions that explore the role of biomechanics, the material properties of the extracellular matrix, cytoskeletal responses, and mechanosensitive signaling in the context of regeneration. Studies employing biophysical techniques, modeling, and engineered systems to dissect mechanical contributions to regenerative processes are highly encouraged. Interdisciplinary approaches bridging physics, engineering, and cell biology are particularly relevant. Our goal is to highlight how physical factors contribute to regenerative outcomes and promote a deeper mechanistic understanding to advance regenerative medicine one day at a time.

Dr. Christopher Robinson
Dr. Alan David Kaye
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biophysica is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomechanics
  • mechanotransduction
  • tissue repair
  • cytoskeleton

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Published Papers (2 papers)

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Research

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16 pages, 6746 KB  
Article
Comparative Experimental and Viscoelastic Modeling Study of Human Tibial Trabecular Bone Under Healthy and Osteoarthritic Conditions
by Saida Benhmida, Hanene Boussi Rahmouni, Ridha Hambli and Hedi Trabelsi
Biophysica 2026, 6(4), 77; https://doi.org/10.3390/biophysica6040077 - 21 Aug 2026
Viewed by 203
Abstract
Background: The development of osteoarthritis (OA), a whole-joint disorder that is increasingly recognized, depends on subchondral trabecular bone. Variations in the viscoelastic characteristics of trabecular bone have been proposed to affect load distribution and potentially lead to joint degradation. The viscoelastic response of [...] Read more.
Background: The development of osteoarthritis (OA), a whole-joint disorder that is increasingly recognized, depends on subchondral trabecular bone. Variations in the viscoelastic characteristics of trabecular bone have been proposed to affect load distribution and potentially lead to joint degradation. The viscoelastic response of human trabecular bone in both healthy and osteoarthritic situations was investigated using constitutive modeling and stress-relaxation testing. Fifteen tibial trabecular bone specimens were evaluated using Standard Linear Solid (SLS) models and two-branch generalized Maxwell models following uniaxial stress-relaxation testing. Mechanical, energy, and relaxation-related traits were retrieved and compared between groups. Results: Healthy bone tended to relax stress more slowly and to bear mechanical loads over time to a slightly greater extent than osteoarthritic bone, which tended to relax stress more quickly and had poorer mechanical endurance; these differences were not statistically significant. The Generalized Maxwell model suited the experimental data better than the SLS model (R2 > 0.98), capturing both short- and long-term relaxation mechanisms. Sensitivity analysis revealed higher parameter variability in OA specimens, suggesting possible differences in mechanical heterogeneity and load-dissipation behavior that require further investigation. Conclusions: Although the observed differences were not statistically significant in this exploratory study, the results suggest potential trends toward altered viscoelastic behavior between healthy and osteoarthritic trabecular bone. Future studies with larger cohorts are needed to further investigate osteoarthritis-related biomechanical alterations. Multi-branch viscoelastic modeling may provide sensitive mechanical descriptors for characterizing the relaxation behavior of subchondral bone. Full article
(This article belongs to the Special Issue Mechanobiology of Regeneration: From Physical Aspects)
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Review

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24 pages, 3657 KB  
Review
Platelet-Rich Plasma: Mechanotransduction, Tissue Loading, and Regenerative Repair for Pain Medicine
by Ahmed I. Anwar, Josephine M. Feeney, Joseph B. Delaney, Christopher L. Robinson, Jamal Hasoon and Alan D. Kaye
Biophysica 2026, 6(4), 59; https://doi.org/10.3390/biophysica6040059 - 9 Jul 2026
Viewed by 704
Abstract
Musculoskeletal pain is driven by degenerative conditions such as osteoarthritis or intervertebral disk degeneration. This creates a major burden on health systems and patient quality of life. Platelet-rich plasma (PRP) is an orthobiologic that contains platelets and growth factors which promote angiogenesis, modulate [...] Read more.
Musculoskeletal pain is driven by degenerative conditions such as osteoarthritis or intervertebral disk degeneration. This creates a major burden on health systems and patient quality of life. Platelet-rich plasma (PRP) is an orthobiologic that contains platelets and growth factors which promote angiogenesis, modulate inflammation, and support tissue repair. Mechanobiology is central in the healing process, where mechanical loading regulates cellular behavior through mechanotransduction pathways including integrin/FAK and RhoA/ROCK. This use of signaling pathways allows for regeneration along multiple different tissue types. Evidence suggests that PRP and mechanical loading may act together to promote tissue repair, with PRP-derived signals interacting with biomechanical cues to enhance fibroblast activation, remodeling, and regenerative responses. There is variability in PRP preparation, rehabilitation protocols, and tissue-specific responses, which all highlight the need for a more standardized and guided treatment strategy. Understanding the interplay between PRP-derived biologic signaling and mechanobiologic pathways may help inform the development of more standardized, tissue-specific regenerative treatment strategies and could potentially contribute to improved clinical outcomes in patients with musculoskeletal pain. Full article
(This article belongs to the Special Issue Mechanobiology of Regeneration: From Physical Aspects)
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