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3 Results Found

  • Review
  • Open Access
19 Citations
8,344 Views
18 Pages

Generation of Human Stomach Cancer iPSC-Derived Organoids Induced by Helicobacter pylori Infection and Their Application to Gastric Cancer Research

  • Chia-Chen Ku,
  • Kenly Wuputra,
  • Jia-Bin Pan,
  • Chia-Pei Li and ,
  • Chung-Jung Liu,
  • Yi-Chang Liu,
  • Shigeo Saito,
  • Te-Fu Chan,
  • Chang-Shen Lin and
  • Kazunari K. Yokoyama
  • + 6 authors+ 1 author

6 January 2022

There is considerable cellular diversity in the human stomach, which has helped to clarify cell plasticity in normal development and tumorigenesis. Thus, the stomach is an interesting model for understanding cellular plasticity and for developing pro...

(This article belongs to the Special Issue Induced Pluripotent Stem Cells (IPSC) as a Disease Modeling and Drug Development Platform)
  • Review
  • Open Access
12 Citations
5,741 Views
20 Pages

Stem Cell Biomarkers and Tumorigenesis in Gastric Cancer

  • Kenly Wuputra,
  • Chia-Chen Ku,
  • Jia-Bin Pan,
  • Chung-Jung Liu and ,
  • Yi-Chang Liu,
  • Shigeo Saito,
  • Kohsuke Kato,
  • Ying-Chu Lin,
  • Kung-Kai Kuo and
  • Kazunari K. Yokoyama
  • + 9 authors+ 4 authors

Stomach cancer has a high mortality, which is partially caused by an absence of suitable biomarkers to allow detection of the initiation stages of cancer progression. Thus, identification of critical biomarkers associated with gastric cancer (GC) is...

(This article belongs to the Section Personalized Therapy in Clinical Medicine)
  • Review
  • Open Access
27 Citations
13,319 Views
9 Pages

Gastric Stem Cell and Cellular Origin of Cancer

  • Masahiro Hata,
  • Yoku Hayakawa and
  • Kazuhiko Koike

Several stem cell markers within the gastrointestinal epithelium have been identified in mice. One of the best characterized is Lgr5 (leucine-rich repeat-containing G-protein coupled receptor 5) and evidence suggests that Lgr5+ cells in the gut are t...

(This article belongs to the Special Issue Stem Cells and Cancer Therapeutics)