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8 Results Found

  • Article
  • Open Access
14 Citations
4,318 Views
17 Pages
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RSK1 vs. RSK2 Inhibitory Activity of the Marine β-Carboline Alkaloid Manzamine A: A Biochemical, Cervical Cancer Protein Expression, and Computational Study

  • Alejandro M. S. Mayer,
  • Mary L. Hall,
  • Joseph Lach,
  • Jonathan Clifford,
  • Kevin Chandrasena,
  • Caitlin Canton,
  • Maria Kontoyianni,
  • Yeun-Mun Choo,
  • Dev Karan and
  • Mark T. Hamann
Mar. Drugs2021, 19(9), 506;https://doi.org/10.3390/md19090506

7 September 2021

Manzamines are complex polycyclic marine-derived β-carboline alkaloids with reported anticancer, immunostimulatory, anti-inflammatory, antibacterial, antiviral, antimalarial, neuritogenic, hyperlipidemia, and atherosclerosis suppression bioactivities...

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  • Review
  • Open Access
1 Citations
3,669 Views
13 Pages
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Efficiency of Fulvestrant Monotherapy After CDK4/6 Inhibitor Exposure: Is This a Viable Choice?

  • Nanae Ogata,
  • Brian G Barnett,
  • Nicholas J. H. Sharp,
  • Takeo Fujii,
  • Toshiaki Iwase,
  • Sandra E. Dunn and
  • Naoto T. Ueno
Cancers2025, 17(5), 884;https://doi.org/10.3390/cancers17050884

4 March 2025

Guidelines for the first-line treatment of Hormone Receptor-positive, HER2-negative advanced or recurrent breast cancer have shifted to combination therapies of a CDK4/6 inhibitor and endocrine therapy. However, determining an optimal subsequent ther...

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  • Article
  • Open Access
2 Citations
2,735 Views
16 Pages
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Hepatitis B Virus X Protein Modulates p90 Ribosomal S6 Kinase 2 by ERK to Promote Growth of Hepatoma Cells

  • Ning Han,
  • Qingbo Zhang,
  • Xiaoqiong Tang,
  • Lang Bai,
  • Libo Yan and
  • Hong Tang
Viruses2023, 15(5), 1182;https://doi.org/10.3390/v15051182

17 May 2023

Hepatitis B virus (HBV) infection is a leading cause of hepatocellular carcinoma (HCC), one of the most prevalent malignant tumors worldwide that poses a significant threat to human health. The multifunctional regulator known as Hepatitis B virus X-p...

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  • Article
  • Open Access
12 Citations
5,327 Views
17 Pages
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mTORC2 Is Involved in the Induction of RSK Phosphorylation by Serum or Nutrient Starvation

  • Po-Chien Chou,
  • Swati Rajput,
  • Xiaoyun Zhao,
  • Chadni Patel,
  • Danielle Albaciete,
  • Won Jun Oh,
  • Heineken Queen Daguplo,
  • Nikhil Patel,
  • Bing Su and
  • Estela Jacinto
  • + 1 author
Cells2020, 9(7), 1567;https://doi.org/10.3390/cells9071567

27 June 2020

Cells adjust to nutrient fluctuations to restore metabolic homeostasis. The mechanistic target of rapamycin (mTOR) complex 2 responds to nutrient levels and growth signals to phosphorylate protein kinases belonging to the AGC (Protein Kinases A,G,C)...

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  • Article
  • Open Access
8 Citations
5,613 Views
25 Pages
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Nerve Growth Factor Signaling from Membrane Microdomains to the Nucleus: Differential Regulation by Caveolins

  • Ambre Spencer,
  • Lingli Yu,
  • Vincent Guili,
  • Florie Reynaud,
  • Yindi Ding,
  • Ji Ma,
  • Jérôme Jullien,
  • David Koubi,
  • Emmanuel Gauthier and
  • Brian B. Rudkin
  • + 4 authors
Int. J. Mol. Sci.2017, 18(4), 693;https://doi.org/10.3390/ijms18040693

24 March 2017

Membrane microdomains or “lipid rafts” have emerged as essential functional modules of the cell, critical for the regulation of growth factor receptor-mediated responses. Herein we describe the dichotomy between caveolin-1 and caveolin-2, structural...

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  • Article
  • Open Access
8 Citations
4,261 Views
15 Pages
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NLRP1 Functions Downstream of the MAPK/ERK Signaling via ATF4 and Contributes to Acquired Targeted Therapy Resistance in Human Metastatic Melanoma

  • Zili Zhai,
  • Prasanna K. Vaddi,
  • Jenny Mae Samson,
  • Tomoya Takegami and
  • Mayumi Fujita
Pharmaceuticals2021, 14(1), 23;https://doi.org/10.3390/ph14010023

30 December 2020

The BRAF V600E mutation leads to constitutive activation of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway and its downstream effector responses. Uncovering the hidden downstream effectors can aid in u...

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  • Review
  • Open Access
66 Citations
5,302 Views
8 Pages
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Role of BRAF in Hepatocellular Carcinoma: A Rationale for Future Targeted Cancer Therapies

  • Antonio Gnoni,
  • Antonella Licchetta,
  • Riccardo Memeo,
  • Antonella Argentiero,
  • Antonio G. Solimando,
  • Vito Longo,
  • Sabina Delcuratolo and
  • Oronzo Brunetti
Medicina2019, 55(12), 754;https://doi.org/10.3390/medicina55120754

21 November 2019

The few therapeutic strategies for advance hepatocellular carcinoma (HCC) on poor knowledge of its biology. For several years, sorafenib, a tyrosine kinase inhibitors (TKI) inhibitor, has been the approved treatment option, to date, for advanced HCC...

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  • Article
  • Open Access
13 Citations
4,049 Views
21 Pages
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EPHA2 Interacts with DNA-PKcs in Cell Nucleus and Controls Ionizing Radiation Responses in Non-Small Cell Lung Cancer Cells

  • Vitaliy O. Kaminskyy,
  • Petra Hååg,
  • Metka Novak,
  • Ákos Végvári,
  • Vasiliki Arapi,
  • Rolf Lewensohn and
  • Kristina Viktorsson
Cancers2021, 13(5), 1010;https://doi.org/10.3390/cancers13051010

28 February 2021

Ephrin (EFN)/Erythropoietin-producing human hepatocellular receptors (Eph) signaling has earlier been reported to regulate non-small cell lung cancer (NSCLC) cell survival and cell death as well as invasion and migration. Here, the role of Ephrin typ...

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