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Article

35 Citations

8,160 Views

14 Pages

Identification and Characterisation of the Antimicrobial Peptide, Phylloseptin-PT, from the Skin Secretion of Phyllomedusa tarsius, and Comparison of Activity with Designed, Cationicity-Enhanced Analogues and Diastereomers

Yitian Gao,
Di Wu,
Xinping Xi,
Yue Wu,
Chengbang Ma,
Mei Zhou,
Lei Wang,
Mu Yang,
Tianbao Chen and
Chris Shaw

Molecules2016, 21(12), 1667;https://doi.org/10.3390/molecules21121667

3 December 2016

Antimicrobial peptides belonging to the phylloseptin family are mainly found in phyllomedusine frogs. These peptides not only possess potent antimicrobial activity but exhibit low toxicity against eukaryotic cells. Therefore, they are considered as p...

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Article

5 Citations

2,344 Views

23 Pages

Enhancement of Antimicrobial Function by L/D-Lysine Substitution on a Novel Broad-Spectrum Antimicrobial Peptide, Phylloseptin-TO2: A Structure-Related Activity Research Study

Weining Yin,
Junting Yao,
Xuwei Leng,
Chengbang Ma,
Xiaoling Chen,
Yangyang Jiang,
Tao Wang,
Tianbao Chen,
Chris Shaw and
Lei Wang
+ 1 author

Pharmaceutics2024, 16(8), 1098;https://doi.org/10.3390/pharmaceutics16081098

21 August 2024

Antibiotic resistance poses a serious threat to public health globally, reducing the effectiveness of conventional antibiotics in treating bacterial infections. ESKAPE pathogens are a group of highly transmissible bacteria that mainly contribute to t...

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Article

21 Citations

6,352 Views

21 Pages

Discovery of Phylloseptins that Defense against Gram-Positive Bacteria and Inhibit the Proliferation of the Non-Small Cell Lung Cancer Cell Line, from the Skin Secretions of Phyllomedusa Frogs

Jia Liu,
Qing Wu,
Lei Li,
Xinping Xi,
Di Wu,
Mei Zhou,
Tianbao Chen,
Chris Shaw and
Lei Wang

Molecules2017, 22(9), 1428;https://doi.org/10.3390/molecules22091428

29 August 2017

The growing occurrence of bacterial resistance to conventional antibiotics has called for the development of new classes of antimicrobial agents. Antimicrobial peptides (AMPs) with broad antimicrobial spectrum derived from frog skin secretions have b...

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Article

9 Citations

6,449 Views

21 Pages

Discovery of Novel Bacterial Cell-Penetrating Phylloseptins in Defensive Skin Secretions of the South American Hylid Frogs, Phyllomedusa duellmani and Phyllomedusa coelestis

Nan Yang,
Lei Li,
Di Wu,
Yitian Gao,
Xinping Xi,
Mei Zhou,
Lei Wang,
Tianbao Chen and
Chris Shaw

Toxins2016, 8(9), 255;https://doi.org/10.3390/toxins8090255

31 August 2016

Phylloseptin (PS) peptides, derived from South American hylid frogs (subfamily Phyllomedusinae), have been found to have broad-spectrum antimicrobial activities and relatively low haemolytic activities. Although PS peptides have been identified from...

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Article

31 Citations

8,279 Views

13 Pages

The Skin Secretion of the Amphibian Phyllomedusa nordestina: A Source of Antimicrobial and Antiprotozoal Peptides

Guilherme D. Brand,
Raimunda C. Santos,
Luisa Mayumi Arake,
Valdelânia G. Silva,
Leiz M. C. Veras,
Vladimir Costa,
Carlos Henrique N. Costa,
Selma S. Kuckelhaus,
José Guilherme Alexandre and
José Roberto S. A. Leite
+ 1 author

Molecules2013, 18(6), 7058-7070;https://doi.org/10.3390/molecules18067058

17 June 2013

Antimicrobial peptides (AMPs) from the dermaseptin and phylloseptin families were isolated from the skin secretion of Phyllomedusa nordestina, a recently described amphibian species from Northeastern Brazil. One dermaseptin and three phylloseptins we...

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Article

14 Citations

3,166 Views

14 Pages

Phylloseptin-1 is Leishmanicidal for Amastigotes of Leishmania amazonensis Inside Infected Macrophages

Selma A. S. Kückelhaus,
Daniela Sant’Ana de Aquino,
Tatiana K. Borges,
Daniel C. Moreira,
Luciana de Magalhães Leite,
Maria Imaculada Muniz-Junqueira,
Carlos S. Kückelhaus,
Gustavo A. Sierra Romero,
Maura V. Prates and
José Roberto S. A. Leite
+ 1 author

Int. J. Environ. Res. Public Health2020, 17(13), 4856;https://doi.org/10.3390/ijerph17134856

6 July 2020

Leishmania protozoans are the causal agents of neglected diseases that represent an important public health issue worldwide. The growing occurrence of drug-resistant strains of Leishmania and severe side effects of available treatments represent an i...

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Article

24 Citations

8,912 Views

12 Pages

Phylloseptin-PBa—A Novel Broad-Spectrum Antimicrobial Peptide from the Skin Secretion of the Peruvian Purple-Sided Leaf Frog (Phyllomedusa Baltea) Which Exhibits Cancer Cell Cytotoxicity

Yuantai Wan,
Chengbang Ma,
Mei Zhou,
Xinping Xi,
Lei Li,
Di Wu,
Lei Wang,
Chen Lin,
Juan Chavez Lopez and
Chris Shaw
+ 1 author

Toxins2015, 7(12), 5182-5193;https://doi.org/10.3390/toxins7124878

1 December 2015

Antimicrobial peptides from amphibian skin secretion display remarkable broad-spectrum antimicrobial activity and are thus promising for the discovery of new antibiotics. In this study, we report a novel peptide belonging to the phylloseptin family o...

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Article

24 Citations

5,986 Views

16 Pages

PSN-PC: A Novel Antimicrobial and Anti-Biofilm Peptide from the Skin Secretion of Phyllomedusa-camba with Cytotoxicity on Human Lung Cancer Cell

Xianhui Wu,
Jinhuo Pan,
Yue Wu,
Xinping Xi,
Chengbang Ma,
Lei Wang,
Mei Zhou and
Tianbao Chen

Molecules2017, 22(11), 1896;https://doi.org/10.3390/molecules22111896

7 November 2017

Peptides derived from amphibian skin secretion are promising drug prototypes for combating widespread infection. In this study, a novel peptide belonging to the phylloseptin family of antimicrobial peptides was isolated from the skin secretion of the...

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Article

18 Citations

8,594 Views

20 Pages

Unravelling the Skin Secretion Peptides of the Gliding Leaf Frog, Agalychnis spurrelli (Hylidae)

Carolina Proaño-Bolaños,
Ailín Blasco-Zúñiga,
José Rafael Almeida,
Lei Wang,
Miguel Angel Llumiquinga,
Miryan Rivera,
Mei Zhou,
Tianbao Chen and
Chris Shaw

Biomolecules2019, 9(11), 667;https://doi.org/10.3390/biom9110667

30 October 2019

Frog skin secretions contain medically-valuable molecules, which are useful for the discovery of new biopharmaceuticals. The peptide profile of the skin secretion of Agalychnis spurrelli has not been investigated; therefore, the structural and biolog...

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9 Results Found

Identification and Characterisation of the Antimicrobial Peptide, Phylloseptin-PT, from the Skin Secretion of Phyllomedusa tarsius, and Comparison of Activity with Designed, Cationicity-Enhanced Analogues and Diastereomers

Enhancement of Antimicrobial Function by L/D-Lysine Substitution on a Novel Broad-Spectrum Antimicrobial Peptide, Phylloseptin-TO2: A Structure-Related Activity Research Study

Discovery of Phylloseptins that Defense against Gram-Positive Bacteria and Inhibit the Proliferation of the Non-Small Cell Lung Cancer Cell Line, from the Skin Secretions of Phyllomedusa Frogs

Discovery of Novel Bacterial Cell-Penetrating Phylloseptins in Defensive Skin Secretions of the South American Hylid Frogs, Phyllomedusa duellmani and Phyllomedusa coelestis

The Skin Secretion of the Amphibian Phyllomedusa nordestina: A Source of Antimicrobial and Antiprotozoal Peptides

Phylloseptin-1 is Leishmanicidal for Amastigotes of Leishmania amazonensis Inside Infected Macrophages

Phylloseptin-PBa—A Novel Broad-Spectrum Antimicrobial Peptide from the Skin Secretion of the Peruvian Purple-Sided Leaf Frog (Phyllomedusa Baltea) Which Exhibits Cancer Cell Cytotoxicity

PSN-PC: A Novel Antimicrobial and Anti-Biofilm Peptide from the Skin Secretion of Phyllomedusa-camba with Cytotoxicity on Human Lung Cancer Cell

Unravelling the Skin Secretion Peptides of the Gliding Leaf Frog, Agalychnis spurrelli (Hylidae)