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9 Results Found

  • Article
  • Open Access
4 Citations
3,182 Views
18 Pages

24 July 2024

Background: Colorectal cancer (CRC) ranks among the most prevalent malignancies affecting the gastrointestinal tract. The infiltration of CD8+ T cells significantly influences the prognosis and progression of tumor patients. Methods: This study estab...

  • Article
  • Open Access
16 Citations
4,768 Views
33 Pages

Pan-Cancer Analysis of Prognostic and Immune Infiltrates for CXCs

  • Long Li,
  • Wenchao Yao,
  • Sen Yan,
  • Xianghui Dong,
  • Zhenyi Lv,
  • Qingxu Jing,
  • Qiang Wang,
  • Biao Ma,
  • Chenjun Hao and
  • Dawei Wang
  • + 1 author

18 August 2021

Background: CXCs are important genes that regulate inflammation and tumor metastasis. However, the expression level, prognosis value, and immune infiltration of CXCs in cancers are not clear. Methods: Multiple online datasets were used to analyze the...

  • Article
  • Open Access
6 Citations
2,850 Views
19 Pages

Cuproptosis and Immune-Related Gene Signature Predicts Immunotherapy Response and Prognosis in Lung Adenocarcinoma

  • Zihao Sun,
  • Xiujing Chen,
  • Xiaoning Huang,
  • Yanfen Wu,
  • Lijuan Shao,
  • Suna Zhou,
  • Zhu Zheng,
  • Yiguang Lin and
  • Size Chen

19 July 2023

Cuproptosis and associated immune-related genes (IRG) have been implicated in tumorigenesis and tumor progression. However, their effects on lung adenocarcinoma (LUAD) have not been elucidated. Therefore, we investigated the impact of cuproptosis-ass...

  • Article
  • Open Access
1 Citations
1,163 Views
15 Pages

Background: Sepsis is a complex syndrome caused by a severe infection that occurs with a severe inflammatory response. Regulatory T cells (Tregs) have immunosuppressive effects and play a crucial role in modulating the immune response. There-fore, th...

  • Article
  • Open Access
6 Citations
2,964 Views
18 Pages

30 January 2023

Multi-omics expression datasets obtained from multiple public databases were used to elucidate the biological function of TK1 and its effects on clinical outcomes. The Kaplan–Meier curve, a predictive nomogram mode, and the time-dependent recei...

  • Article
  • Open Access
5 Citations
2,909 Views
21 Pages

Development of a Macrophage-Related Risk Model for Metastatic Melanoma

  • Zhaoxiang Li,
  • Xinyuan Zhang,
  • Quanxin Jin,
  • Qi Zhang,
  • Qi Yue,
  • Manabu Fujimoto and
  • Guihua Jin

6 September 2023

As a metastasis-prone malignancy, the metastatic form and location of melanoma seriously affect its prognosis. Although effective surgical methods and targeted drugs are available to enable the treatment of carcinoma in situ, for metastatic tumors, t...

  • Article
  • Open Access
10 Citations
3,287 Views
17 Pages

22 October 2023

Background: Cuproptosis induction is seen as a promising alternative for immunotherapies and targeted therapies in breast cancer. The objective of this research was to examine the prognostic and biological importance of cuproptosis-related genes (CRG...

  • Article
  • Open Access
1 Citations
3,295 Views
16 Pages

29 November 2024

Background/Objectives: Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) with a relapsing nature and complex etiology. Bioinformatics analysis has been widely applied to investigate various diseases. This study aimed to identify c...

  • Article
  • Open Access
918 Views
29 Pages

17 September 2025

Objective: This study aims to explore the mechanism of regulated cell death-related genes in the development of endometrial carcinoma. Methods: Endometrial carcinoma-related datasets were yielded via the Cancer Genome Atlas and Gene Expression Omnibu...