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9 Results Found

  • Feature Paper
  • Article
  • Open Access
6 Citations
5,959 Views
11 Pages

Background: Functional Hypothalamic Amenorrhea (FHA) is a stress-induced blockade of the reproductive axis. Such impairment is mainly due to altered control of GnRH-induced gonadotropin secretion as well as alterations of other endocrine functions. M...

  • Review
  • Open Access
3 Citations
6,896 Views
10 Pages

Low-Dose Estrogens as Neuroendocrine Modulators in Functional Hypothalamic Amenorrhea (FHA): The Putative Triggering of the Positive Feedback Mechanism(s)

  • Christian Battipaglia,
  • Tabatha Petrillo,
  • Elisa Semprini,
  • Francesco Ricciardiello,
  • Maria Laura Rusce,
  • Greta Prampolini,
  • Fedora Ambrosetti,
  • Alessandra Sponzilli and
  • Alessandro D. Genazzani

Functional hypothalamic amenorrhea (FHA) is a non-organic reversible chronic endocrine disorder characterized by an impaired pulsatile secretion of the gonadotropin-releasing hormone (GnRH) from the hypothalamus. This impaired secretion, triggered by...

  • Review
  • Open Access
12 Citations
4,707 Views
12 Pages

Neuroendocrine Effects of Carnitines on Reproductive Impairments

  • Tabatha Petrillo,
  • Christian Battipaglia,
  • Mohamed Ashraf Virmani,
  • Andrea R. Genazzani and
  • Alessandro D. Genazzani

5 October 2021

Carnitines are quaternary amines involved in various cellular processes such as fatty acid uptake, β-oxidation and glucose metabolism regulation. Due to their neurotrophic activities, their integrative use has been studied in several different physio...

  • Review
  • Open Access
8 Citations
16,661 Views
16 Pages

Dietary and Lifestyle Management of Functional Hypothalamic Amenorrhea: A Comprehensive Review

  • Katarzyna Dobranowska,
  • Stanisława Plińska and
  • Agnieszka Dobosz

3 September 2024

Functional Hypothalamic Amenorrhea (FHA) is a condition characterized by the absence of menstruation, which is increasingly affecting young women. However, specific recommendations for treating and preventing this condition are lacking. Based on a re...

  • Review
  • Open Access
15 Citations
4,719 Views
21 Pages

The Role of Irisin throughout Women’s Life Span

  • Federica Barbagallo,
  • Rossella Cannarella,
  • Vincenzo Garofalo,
  • Marta Marino,
  • Sandro La Vignera,
  • Rosita A. Condorelli,
  • Lara Tiranini,
  • Rossella E. Nappi and
  • Aldo E. Calogero

Since its discovery, much attention has been drawn to irisin’s potential role in metabolic and reproductive diseases. This narrative review summarizes and updates the possible role played by this fascinating molecule in different physiological (puber...

  • Review
  • Open Access
29 Citations
26,242 Views
16 Pages

17 August 2021

Functional hypothalamic amenorrhea (FHA) is a very common condition affecting women of procreative age. There are many reasons for this disorder, including a low availability of energy in the diet, low micro- and macronutrient intake, overly intensiv...

  • Feature Paper
  • Article
  • Open Access
16 Citations
3,761 Views
11 Pages

26 October 2022

(1) Background: Functional Hypothalamic Amenorrhea (FHA) can be caused by the hyper activation of neuro-endocrine responses to stress. Among other endocrine factors and hypothalamic dysfunctions, the psychophysiological stress response can very frequ...

  • Article
  • Open Access
9 Citations
26,342 Views
11 Pages

The LH:FSH Ratio in Functional Hypothalamic Amenorrhea: An Observational Study

  • Magdalena Boegl,
  • Didier Dewailly,
  • Rodrig Marculescu,
  • Johanna Steininger,
  • Johannes Ott and
  • Marlene Hager

20 February 2024

Background: In functional hypothalamic amenorrhea (FHA), luteinizing hormone and follicle-stimulating hormone levels show high interindividual variability, which significantly limits their diagnostic value in differentiating FHA from polycystic ovary...

  • Article
  • Open Access
2,388 Views
16 Pages

Metabolic and Endocrine Alterations in Underweight and Normal-Weight Women with Functional Hypothalamic Amenorrhea

  • Karolina Kowalczyk,
  • Iga Szymańska,
  • Olga Zawistowska,
  • Julia Bieńkowska,
  • Agnieszka Drosdzol-Cop and
  • Paweł Madej

7 October 2025

Background: Functional hypothalamic amenorrhea (FHA) is a form of chronic anovulation associated with hypoestrogenism. Weight loss, excessive exercise, stress and long-lasting hypoestrogenism lead to infertility and bone loss. FHA also leads to metab...