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11 Results Found

  • Article
  • Open Access
16 Citations
5,225 Views
13 Pages

Characteristics of a Colistin-Resistant Escherichia coli ST695 Harboring the Chromosomally-Encoded mcr-1 Gene

  • Zhong Peng,
  • Zizhe Hu,
  • Zugang Li,
  • Xiaosong Li,
  • Chaoying Jia,
  • Xiaoxue Zhang,
  • Bin Wu,
  • Huanchun Chen and
  • Xiangru Wang

Enterobacteriaceae having chromosomally-encoded mcr-1 is rarely reported. In this study, we recovered a chromosomal mcr-1 carrying Escherichia coli, designated HeN100, from the feces of a diarrheal pig in China. Antimicrobial susceptibility testing s...

  • Review
  • Open Access
117 Citations
10,269 Views
38 Pages

The emergence and spread of mobile colistin (COL) resistance (mcr) genes jeopardize the efficacy of COL, a last resort antibiotic for treating deadly infections. COL has been used in livestock for decades globally. Bacteria have mobilized mcr genes (...

  • Article
  • Open Access
20 Citations
3,289 Views
13 Pages

Genomic Analysis of Aeromonas veronii C198, a Novel Mcr-3.41-Harboring Isolate from a Patient with Septicemia in Thailand

  • Rujirat Hatrongjit,
  • Anusak Kerdsin,
  • Dan Takeuchi,
  • Thidathip Wongsurawat,
  • Piroon Jenjaroenpun,
  • Peechanika Chopjitt,
  • Parichart Boueroy,
  • Yukihiro Akeda and
  • Shigeyuki Hamada

9 December 2020

The resistance of Gram-negative bacteria to colistin, mediated by plasmid-borne mcr genes, is an emerging public health concern. The complete genome sequence (4.55 Mb) of a clinical isolate of Aeromonas veronii biovar veronii obtained from a p...

  • Review
  • Open Access
34 Citations
7,117 Views
53 Pages

Mobile Colistin Resistance (mcr) Gene-Containing Organisms in Poultry Sector in Low- and Middle-Income Countries: Epidemiology, Characteristics, and One Health Control Strategies

  • Madubuike Umunna Anyanwu,
  • Ishmael Festus Jaja,
  • Charles Odilichukwu R. Okpala,
  • Emmanuel Okechukwu Njoga,
  • Nnenna Audrey Okafor and
  • James Wabwire Oguttu

Mobile colistin resistance (mcr) genes (mcr-1 to mcr-10) are plasmid-encoded genes that threaten the clinical utility of colistin (COL), one of the highest-priority critically important antibiotics (HP-CIAs) used to treat infections caused by multidr...

  • Review
  • Open Access
506 Views
28 Pages

Colistin Resistance in Gram-Negative Bacteria: Mechanisms, Transmission, and Novel Intervention Strategies

  • Shah Zeb,
  • Arzoo Nazir,
  • Muhammad Fazal Hameed,
  • Sadia Ikram,
  • Syed Zeeshan Haider Naqvi,
  • Muhammad Shoaib,
  • Patrick Butaye,
  • Zhiqiang Wang,
  • Ruichao Li and
  • Xiaoyu Lu

Multidrug resistance (MDR) in Gram-negative bacteria is a global issue and needs to be addressed urgently. MDR can emerge through genetic mutations and horizontal gene transfer and deteriorate under antibiotic selective pressure. The emergence of res...

  • Article
  • Open Access
8 Citations
4,078 Views
13 Pages

The spread of multidrug-resistant enterobacteria strains has posed a significant concern in public health, especially when the strain harbors metallo-beta-lactamase (MBL)-encoding and mobilized colistin resistance (mcr) genes as such genetic componen...

  • Article
  • Open Access
4 Citations
3,389 Views
16 Pages

Evaluation of the EasyScreen™ ESBL/CPO Detection Kit for the Detection of ß-Lactam Resistance Genes

  • Camille Gonzalez,
  • Saoussen Oueslati,
  • Laura Biez,
  • Laurent Dortet and
  • Thierry Naas

14 September 2022

Early detection of multidrug resistant bacteria is of paramount importance for implementing appropriate infection control strategies and proper antibacterial therapies. We have evaluated a novel real-time PCR assay using fluorescent probes and 3base&...

  • Review
  • Open Access
105 Citations
14,616 Views
19 Pages

Acinetobacter baumannii is recognized as a clinically significant pathogen causing a wide spectrum of nosocomial infections. Colistin was considered a last-resort antibiotic for the treatment of infections caused by multidrug-resistant A. baumannii....

  • Article
  • Open Access
11 Citations
4,771 Views
19 Pages

In the thermophilic biogas-producing microbial community, the genus Methanothermobacter was previously described to be frequently abundant. The aim of this study was to establish and analyze the genome sequence of the archaeal strain Methanothermobac...

  • Review
  • Open Access
14 Citations
6,880 Views
24 Pages

28 November 2024

The emergence of antibiotic-resistant Acinetobacter baumannii (A. baumannii) is a pressing threat in clinical settings. Colistin is currently a widely used treatment for multidrug-resistant A. baumannii, serving as the last line of defense. However,...

  • Article
  • Open Access
5 Citations
133 Views

Polyclonal Spread of Colistin Resistant Klebsiella pneumoniae in Croatian Hospitals and Outpatient Setting

  • Tatjana Tot,
  • Sara Kibel,
  • Sanda Sardelić,
  • Khalil Nemer,
  • Ana Benčić,
  • Jasmina Vraneš,
  • Marija Krilanović,
  • Marko Jelić,
  • Marko Tripković and
  • Branka Bedenić
  • + 1 author
Germs2021, 11(2), 163-178;https://doi.org/10.18683/germs.2021.1254 
(registering DOI)

2 June 2021

Introduction: Recently, a marked increase in the rate of colistin resistant Klebsiella pneumoniae was observed in Croatian hospitals and the outpatient setting. This prompted us to analyze the molecular epidemiology of these isolates and the mechanis...