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9 Results Found

  • Article
  • Open Access
7 Citations
5,178 Views
11 Pages

Balenine, Imidazole Dipeptide Promotes Skeletal Muscle Regeneration by Regulating Phagocytosis Properties of Immune Cells

  • Min Yang,
  • Luchuanyang Sun,
  • Yasunosuke Kawabata,
  • Fumihito Murayama,
  • Takahiro Maegawa,
  • Takeshi Nikawa and
  • Katsuya Hirasaka

5 May 2022

Balenine is one of the endogenous imidazole dipeptides derived from marine products. It is composed of beta-alanine and 3-methyl-L-histidine, which exist mainly in the muscles of marine organisms. The physiological functions of dietary balenine are n...

  • Article
  • Open Access
8 Citations
2,963 Views
12 Pages

Detection of Balenine in Mouse Plasma after Administration of Opah-Derived Balenine by HPLC with PITC Pre-Column Derivatization

  • Yasutaka Shigemura,
  • Yu Iwasaki,
  • Yoshio Sato,
  • Tomomi Kato,
  • Takuya Seko and
  • Kenji Ishihara

18 February 2022

We examined the absorption of balenine (Bal) in mouse blood after the administration of a high-purity Bal prepared from opah muscle. Using HPLC with phenyl isothiocyanate pre-column derivatization, we successfully isolated imidazole peptides and thei...

  • Review
  • Open Access
2 Citations
4,922 Views
19 Pages

27 February 2025

Histidine is an amino acid which plays a critical role in protein synthesis, muscle buffering during anaerobic exercise, and antioxidation. It also acts as a precursor to carnosine, a dipeptide that enhances physical performance by being present in f...

  • Article
  • Open Access
9 Citations
4,215 Views
10 Pages

Quantification of Histidine-Containing Dipeptides in Dolphin Serum Using a Reversed-Phase Ion-Pair High-Performance Liquid Chromatography Method

  • Momochika Kumagai,
  • Sanae Kato,
  • Nanami Arakawa,
  • Mika Otsuka,
  • Takahisa Hamano,
  • Nobuyuki Kashiwagi,
  • Akira Yabuki and
  • Osamu Yamato

The quantification of histidine-containing dipeptides (anserine, carnosine, and balenine) in serum might be a diagnostic tool to assess the health condition of animals. In this study, an existing reversed-phase ion-pair high-performance liquid chroma...

  • Article
  • Open Access
7 Citations
19,962 Views
14 Pages

2 December 2022

2-Oxo-imidazole-containing dipeptides (2-oxo-IDPs), novel imidazole-containing dipeptide (IDP) derivatives, exhibit a much higher antioxidant capacity than that of IDPs. However, quantitative methods have only been developed for IDPs, and methods for...

  • Article
  • Open Access
934 Views
12 Pages

Serum Concentrations of Imidazole Dipeptides and Serum Amyloid A in a Bottlenose Dolphin (Tursiops truncatus) with Rhabdomyolysis: Potential Biomarkers for Muscular Damage

  • Nanami Arakawa,
  • Mika Otsuka,
  • Takahisa Hamano,
  • Momochika Kumagai,
  • Sanae Kato,
  • Takuya Hirai,
  • Akira Yabuki and
  • Osamu Yamato

2 July 2025

Imidazole dipeptides (IDPs), including anserine, carnosine, and balenine, are predominantly found in the skeletal muscles of vertebrates. Balenine is the major IDP in cetaceans. Serum amyloid A (SAA) is an acute phase protein released in response to...

  • Article
  • Open Access
22 Citations
4,479 Views
10 Pages

Activation Effects of Carnosine- and Histidine-Containing Dipeptides on Human Carbonic Anhydrases: A Comprehensive Study

  • Giulio Vistoli,
  • Giancarlo Aldini,
  • Laura Fumagalli,
  • Clelia Dallanoce,
  • Andrea Angeli and
  • Claudiu T. Supuran

l-Carnosine (β-Ala-l-His) and several other histidine-containing peptides, including two N-methylated forms on the imidazole ring (l-anserine and l-balenine), two derivatives modified on the carboxyl function (carcinine and l-carnosinamide), two...

  • Article
  • Open Access
8 Citations
2,433 Views
16 Pages

15 August 2024

Unique metabolites contribute to the performance of meat flavor and potential function. In this study, UHPLC-Q Exactive HF-X-based metabolomics and multivariate analysis were applied to explore the characteristic metabolites in the breast meat of Bei...

  • Article
  • Open Access
1 Citations
2,150 Views
11 Pages

Lifespan Extension and Motor Function Improvement Effects of Whale Meat Extract in Caenorhabditis elegans

  • Junko Shibato,
  • Fumiko Takenoya,
  • Ai Kimura,
  • Michio Yamashita,
  • Randeep Rakwal and
  • Seiji Shioda

28 November 2024

The average life expectancy is increasing worldwide, but the same cannot be said for a healthy life expectancy (defined as the period during which a person can live a healthy and independent life). Therefore, a major challenge is how to extend health...