Search Results (2,884)

Spatially fractionated radiotherapy with X-ray minibeams (x-MBRT) aims to increase normal-tissue tolerance by delivering alternating high- and low-dose regions. We provide a Monte Carlo-based framework to design and optimize multi-slit collimators, quantifying how geometry and material govern peak–valley modulation. A validated digital twin of the SmART X-RAD225Cx irradiator was implemented in TOPAS/Geant4. Various x-MBRT collimators were simulated with parallel or divergent slits. The parameter space covered a slit width w (0.1–0.9 mm), center-to-center spacing CTC (1–3 mm), thickness T (1–5 mm), and acceptance angle θ. Dose was scored in a 2 × 2 × 2 cm³ water phantom at a 1 cm depth. For fixed w/CTC, peak-valley dose ratio PVDR increases with larger CTC via an increase in peak dose, with the valley dose nearly constant. Peak transmission saturated at θ ≈ 3°, indicating minimal benefit from larger acceptance. Divergent slits yielded flatter lateral profiles but higher valley doses than parallel slits, reducing PVDR around the central axis. This Monte Carlo study provides insights for optimizing collimator geometries in x-MBRT using small-animal irradiators, informing the design of more effective collimation systems to enhance treatment precision and normal-tissue sparing. Full article

Dispersed archaeological landscapes are often rich in heritage value but weakly integrated into regional tourism systems. This creates difficulties in visitor orientation, interpretive continuity, and conservation-sensitive tourism planning. In response to this problem, this study examines the Adana–Kozan–Anavarza axis in southern Türkiye and proposes a spatial corridor framework for organising tourism development within a dispersed archaeological landscape. The research integrates spatial accessibility assessment, service-capacity evaluation, field observation, and sequential route design in order to establish a hierarchical gateway–transition–anchor configuration. Anavarza, one of the largest archaeological complexes of Cilicia, represents a monumental urban heritage site and a biocultural landscape situated within a Mediterranean ecological zone historically associated with Pedanius Dioscorides. Although current visitor volumes remain moderate, official statistics indicate a substantial increase in annual entries between 2022 and 2024, reflecting rising destination visibility. This emerging growth trajectory underscores the need for proactive spatial governance mechanisms prior to the onset of congestion and environmental degradation pressures. The findings suggest that Adana can function as a metropolitan gateway, Kozan as an intermediate staging node, and Anavarza as the archaeological anchor within a realistic multi-day visitor sequence. In this configuration, visitor functions are distributed across multiple nodes, while the ecological and archaeological sensitivity of the anchor landscape is more cautiously managed through spatial sequencing. Rather than proposing a predictive model, the study develops and assesses a context-responsive spatial planning framework grounded in accessibility, infrastructural feasibility, and conservation-sensitive visitor distribution. Beyond the local case, the study offers a transferable hierarchical staging logic for corridor-based heritage planning. Full article

In the vehicle electrification sector, the precise and reliable control of e-motors is of the utmost importance for ensuring the efficient and safe operation of the whole electric vehicle drivetrain. Specifically, the assessment of the absolute rotor position of the permanent magnet-based synchronous motors is necessary for precise e-motor control, which is strongly determined by the precision of the sensing device used for the absolute rotor position assessment. Magnetic rotational position sensing devices/encoders are predominantly used in the automotive sector. The accuracy of a magnetic-based rotational position sensing device can be affected by defects/errors which may occur during its manufacturing and/or assembly process. These defects may in turn affect the accuracy of the e-motor’s control and operation. The primary objective of this study was to numerically and experimentally design and investigate the accuracy of a magnetic-based off-axis rotational position sensing device intended for the control of a new permanent magnet e-motor, which was developed for a two-wheeler electric vehicle drivetrain. First, a 3D parametric numerical model of a magnetic rotational position sensing device mounted on the motor shaft was built by virtue of the finite element method (FEM). Based on numerical simulations, the appropriate dimensions of the magnetic ring were determined and the possible errors which may have occurred during its manufacturing process have been numerically imposed and analyzed. Second, the rotor position sensing device was prototyped based on the recommendations obtained with the 3D FEM model. Finally, the accuracy of the designed rotational position device was then experimentally assessed by comparing it to a standardized end-of-shaft rotational position encoder. To evaluate the influence of the possible errors on the e-motor rotor position measurement, the output characteristics of the motor torque as a function of its rotational speed of a real permanent magnet e-motor were experimentally assessed using two different rotational position devices. Based on the numerical end experimental results, we identified the manufacturing errors of the magnetic ring and analyzed their influence on the resulting output characteristics of the e-motor. The results revealed that the magnetic ring eccentricity and its magnetization process could affect the accuracy of the e-motor’s output torque characteristics. Full article

Vertical axis wind turbines (VAWTs) suffer from dynamic stall (DS) at low tip-speed ratios (λ), where cyclic variations in angle of attack (α) dominate the blade aerodynamics, severely undermining aerodynamic performance and power extraction. The coupled influence of airfoil parameters on DS remains unexplored. To address this gap, a fully coupled parametric study using 126 incompressible URANS simulations is conducted, examining three geometric parameters of symmetric airfoils: maximum thickness (t/c), chordwise position of maximum thickness (x_t/c), and leading-edge (LE) radius index (I). The results show that coupled geometric modification fundamentally alters the stall mechanism, shifting it from abrupt, LE-driven separation toward a gradual, trailing-edge (TE)-controlled process as airfoils transition from thin, forward-x_t/c profiles to thicker configurations with aft x_t/c and reduced I. This transition enhances boundary-layer (BL) stability, delays DS onset, weakens dynamic stall vortex (DSV) formation, and mitigates unsteady aerodynamic loading. Within the investigated design space, the best-performing configuration (NACA0024–4.5/3.5) achieves a 73% increase in turbine power coefficient (C_P) relative to the baseline airfoil (NACA0018–6.0/3.0), mainly through passive control of BL separation and vortex development. These findings highlight the limitations of single-parameter optimization and establish a physics-based, coupled-design framework for mitigating DS-induced performance losses in VAWTs. Full article

To address the issue of significantly reduced coupling coefficient and limited transmission efficiency in traditional flat solenoid magnetic couplers within wireless power transfer (WPT) systems under horizontal lateral offset conditions, this paper proposes a design method for a concave flat solenoid coil magnetic coupler for engineering applications, aiming to achieve high misalignment tolerance. An equivalent model of the LCC/S compensation circuit is established, its output characteristics are analyzed, and the parameter configuration method for its resonant elements is derived. Secondly, from the perspective of winding arrangement, the mechanism by which the coil winding method, turn spacing, and port concavity angle affect the uniformity of magnetic field distribution and the retention rate of the coupling coefficient is analyzed in detail, and corresponding parameter trade-off and optimization methods are proposed. Subsequently, a simulation model of multiple configuration magnetic couplers is established based on Ansys/Maxwell, comparing the magnetic field distribution and coupling coefficient variation of different structures under horizontal offset conditions. The results show that the concave structure with a non-uniform arrangement and a port concavity angle of 30° can still maintain a high coupling coefficient and stable transmission performance under a maximum horizontal offset equal to 60% of the corresponding transmitter-side characteristic dimension. To achieve lightweight and integrated design, the receiver is designed with a flexible printed circuit board (FPC) coil structure, meeting the miniaturization and high power density requirements of low-to-medium power portable devices. Finally, a 100 W experimental prototype was built. Experimental results show that within an offset range of ±15 mm on the X-axis and ±30 mm on the Y-axis at the receiver, the system output voltage fluctuation is controlled within 4%, and the maximum transmission efficiency reaches 87.3%. These results verify the feasibility and practical applicability of the proposed magnetic coupler with high misalignment tolerance. Full article

This article explores how fashion, as a culture-intensive industry, can act as a testbed for ecosystem-centred sustainability transitions. Building on debates on the Triple Transition (green, digital, resilience) and the four pillars of sustainability (environmental, social, economic, cultural), the study addresses a theoretical and methodological gap: while transition agendas and sustainability frameworks are well developed at policy and conceptual levels, there is limited empirical integration of these frameworks into design-oriented methods capable of guiding situated organisational decisions in fashion and cultural and creative industries. It proposes a design- and futures-driven methodology that combines intuitive-logics scenario building, horizon scanning and a customised three-axis Polar Map. The Polar Map translates the Triple Transition into three composite orientations: Bios, Techné and Resilience, used to structure four narrative scenarios applied to the fashion ecosystem: Trailblazing Agency, Other-than-Human Agency, Constructive Agency and Normative Agency. Each scenario assembles concepts, weak signals and case examples into plausible configurations of the fashion value chain and its ecosystem. The results show how these scenarios act as meta-narratives, orienting devices and boundary objects that support futures literacy, make the cultural and intangible consequences of design decisions explicit and reveal interdependencies across value chains. Conceptually, the work operationalises combined transitions and the four pillars of sustainability in a flagship CCI; methodologically, it advances a design-oriented adaptation of scenario practices; and practically, it offers organisations narrative tools to rehearse ecosystem-centred innovation pathways. The conclusion reflects on structural constraints and methodological directions for further hybridisation within foresight methods. Full article

Background: Congested tournament schedules impose substantial physiological stress in team sports; however, the integrated endocrine and inflammatory responses to real competitive match load in female handball players remain insufficiently characterized. Objective: This study aimed to characterize the acute biochemical responses, including hormonal, inflammatory, muscle damage, and bone metabolism markers, elicited by competitive tournament load in female handball players and to provide practical insights for optimizing recovery strategies and load management during short-term competitive periods. Methods: In a pre–post study design, venous blood samples were collected from competitive female athletes (n = 8; age 20.83 ± 2.93 years) before the first match and after the fourth consecutive match of an official university qualification tournament. Biochemical analyses included cortisol, insulin, IL-6, creatine kinase (CK), IGF-1, irisin, lactate dehydrogenase (LDH), osteocalcin, and testosterone. Pre-to-post changes were assessed using paired t-tests and effect sizes. Results: Tournament load induced substantial multisystem physiological perturbations. Significant increases were observed in cortisol (p < 0.001), insulin (p = 0.044), IL-6 (p < 0.001), CK (p < 0.001), and osteocalcin (p = 0.005), indicating activation of the hypothalamic–pituitary–adrenal axis, systemic inflammation, muscle membrane disruption, and enhanced bone turnover. Conversely, IGF-1 (p < 0.001) and testosterone (p = 0.004) significantly decreased, reflecting suppression of anabolic signaling and a shift toward a catabolic hormonal environment under cumulative match stress. LDH significantly decreased (p = 0.002), while irisin showed no significant change (p > 0.05). Conclusions: These findings demonstrate that congested tournament schedules provoke an integrated endocrine–inflammatory stress response in female handball players. Importantly, the observed anabolic–catabolic imbalance highlights the need for individualized recovery strategies, optimized load management, and adequate recovery periods to mitigate maladaptation and reduce injury risk during short-term competitive tournaments. Full article

Bending-dominated lattice structures offer superior stability but suffer from low stiffness and natural frequencies, posing resonance risks in aerospace applications. To address this, a novel Membrane-Wrapped Lattice (MWL) encapsulated by a micrometer-scale metallic film is proposed. A theoretical framework based on the tension-compression asymmetry of the membrane is established to analyze the influence of membrane thickness on the neutral axis shift, ultimately deriving analytical formulations for flexural stiffness and natural frequencies. MWL specimens with varying membrane thicknesses (0–50 μm) were fabricated via selective laser melting and adhesive bonding, then subjected to three-point bending and vibration tests. Results demonstrate that wrapping with a 50 μm 316 L stainless steel membrane increases the flexural stiffness by 128% and the fundamental natural frequency by 85%. The experimental measurements align well with theoretical and numerical predictions, validating this lightweight, high-stiffness design strategy. Full article

This paper presents the concept of a 2D m × n waveguide-based power combiner (PC) that is scalable with respect to the operating frequency band and number of input ports. To our knowledge, this work reports the first planar (2D) power combiner, where the input waveguide ports are distributed in two spatial dimensions to form an array, rather than arranged along a single linear (1D) axis as in conventional corporate or cascaded waveguide combiners. The novelty of the approach relies on using H-plane rectangular waveguide T-junctions and low-loss polarization twisters in between vertically stacked T-junctions to facilitate scalability. The work is motivated by the aim to coherently combine the output power of multiple modified uni-traveling carrier (MUTC) terahertz (THz) waveguide photodiodes (PDs) in a 2D array configuration. In the manuscript, the design of a 2 × 2 planar waveguide power combiner for the WR3 band (220–320 GHz) is reported, and it is also shown that this block can be further extended to m × n input ports. Full-wave numerical analysis of the proposed 2 × 2 power combiner shows a return loss of 11 dB at the output port and an average transmission coefficient of about −6.5 dB, i.e., an overall power combining efficiency of ~90%. Furthermore, to enable 2D photodiode array integration, the manuscript presents a new slot-bow tie antenna integrated MUTC photodiode for radiating the optically generated THz power from each PD vertically into the rectangular waveguide. The simulation results of reflection loss and insertion loss for the slot bow-tie antenna are shown to be better than 10 dB and 1.4 dB over the full WR3 band, respectively. To prove scalability of the power combiner concept w.r.t. the number of input ports, a 2 × 4 power combiner is also analyzed. Results reveal a return loss better than 10 dB from 225 to 318 GHz and a transmission coefficient of approximately −9.7 dB at 300 GHz, i.e., a power combining efficiency of ~85%. Full article

This paper presents a zone-based method for the interim verification and spatial metrological characterization of a 2D vision measurement system. The approach relies on a system calibrated along a single axis and employs a stable yet non-calibrated artifact, demonstrating that spatial performance assessment can be achieved without the need for fully calibrated artifacts distributed across the entire field of view. To enable this process, a custom-designed reference standard was developed, providing a straightforward, robust, and cost-effective solution for performing interim verification tasks. The proposed method provides a structured framework for evaluating both precision and spatial consistency across the measurement surface, even in the absence of fully calibrated standards distributed across the surface. The method is applicable to a wide range of vision-based measurement systems, including those supporting industrial Optical Character Recognition (OCR), while maintaining alignment with established metrological principles. When combined with complementary optical performance tests, the approach supports robust and repeatable interim verification strategies in advanced manufacturing metrology. Full article

Glioblastoma (GBM) persists as one of the greatest challenges in the treatment of human cancer, despite extensive efforts to leverage the therapeutic potential of immunotherapy. While checkpoint blockade and other forms of immunotherapy have revolutionized the treatment of various cancers, their therapeutic efficacy in GBM has been hindered by the profound immunosuppressive environment, spatial heterogeneity, and dynamic immune metabolic challenges associated with the tumor microenvironment. In this review, we will synthesize recent advances and insights to develop a next-generation framework for GBM immunotherapy based on systems biology approaches to understanding the complex interplay between GBM and the immune system, as opposed to single-axis approaches to immune activation and modulation. We will discuss how the functional competence of the interferon system, myeloid antigen presentation status, T-cell clone status, spatial organization of the immune microenvironment, and resource competition between GBM and the immune system dictate therapeutic responsiveness. Furthermore, the current paper elucidates how recent advances in spatial transcriptomics, single-cell analysis, and high-parameter imaging enable us to understand how immune phenotype status varies across GBM regions and treatment status, and how this information can be used to develop predictive and pharmacodynamic biomarkers of therapeutic efficacy and failure. We will then discuss how these advances form the basis for rational combination approaches to GBM immunotherapy, which involve the integration of checkpoint blockade with metabolic reprogramming, myeloid modulation, and interferon system reactivation, and how artificial intelligence-based analytics and adaptive clinical trial design can guide the development of biomarker-based therapeutic selection approaches. Full article

This paper presents a low-noise analog front-end (AFE) integrated circuit (IC) circuit for capacitive micro-electromechanical system (MEMS) accelerometers that can be used for optical image stabilization (OIS) in various optical imaging systems. The AFE circuit design features a fully differential chopper stabilization technique that efficiently minimizes low-frequency 1/f noise and parasitic coupling. The AFE circuit chip is fabricated in a 0.18 $\mathsf{\mu }$m complementary metal-oxide-semiconductor (CMOS) technology and co-packaged with an x-axis capacitive MEMS accelerometer based on a silicon-on-glass (SOG) process. The SOG accelerometer has a footprint of 1000 $\mathsf{\mu }\mathrm{m}$ $\times$ 950 $\mathsf{\mu }\mathrm{m}$. The packaged system demonstrates a sensitivity of 342 mV/g and a nonlinearity of 1.1% between −1 g and +1 g, a dynamic range of 88 dB, and an equivalent noise floor of 14 $\mathsf{\mu }\mathrm{g}/\sqrt{\mathrm{H}\mathrm{z}}$. Full article

Conventional buckling-restrained braces (BRBs) with rectangular steel tube confinement suffer from stress concentration and inefficient material utilization, limiting their seismic performance. To address these limitations, this study proposes a novel non-rectangular concrete-filled steel tube BRB system incorporating elliptical and corrugated cross-sections. Comprehensive finite element simulations using ABAQUS are conducted to systematically investigate the influence of key geometric parameters—wall thickness (1–14 mm), corner radius (40–55 mm), and corrugation angle (30–75°)—on hysteretic behavior, load-bearing capacity, and failure modes. The results demonstrate that optimized non-rectangular sections achieve load-bearing capacity comparable to conventional rectangular designs (e.g., elliptical section with 12 mm wall thickness reaches 10.02 MN, a 75% increase over 1 mm thickness) while significantly improving material efficiency. Corrugated sections exhibit enhanced weak-axis performance, with equivalent viscous damping ratios exceeding the NIST-recommended threshold of 0.25. Parametric analyses reveal that wall thickness above 12 mm yields diminishing returns; corner radius reduction to 40 mm triggers local buckling yet increases peak capacity; and corrugation angles exceeding 50° induce instability. All non-buckling models satisfy AISC compression strength adjustment factor requirements (β ≤ 1.3). This study systematically evaluates non-rectangular BRB geometries, filling a critical gap in the literature and providing design guidelines that leverage shape optimization to enhance both seismic resilience and material economy. Full article

Human organoids and organ-on-chip/microphysiological systems (OoC/MPS) are increasingly used as new-approach methodologies for biotoxin assessment. They retain human-relevant tissue organization and enable interpretable analysis of exposure geometry, barrier transport, perfusion, and (when needed) multi-organ coupling. In this review, we synthesize primary evidence across major toxin classes, including bacterial enterotoxins (e.g., cholera toxin, heat-stable enterotoxins, Shiga toxins), mycotoxins (e.g., aflatoxin B1, ochratoxin A, deoxynivalenol), and algal/cyanobacterial toxins (e.g., saxitoxin, domoic acid, microcystins, biliatresone). We emphasize studies that clearly define toxin identity and exposure context and that demonstrate mechanism-critical model competencies under assay conditions. We highlight decision-informative functional endpoints that align with the dominant pathophysiology. These include cystic fibrosis transmembrane conductance regulator (CFTR)-dependent secretion in human enteroids/colonoids, transporter-linked proximal tubular injury in kidney MPS, gut–kidney axis injury from Shiga toxin-producing E. coli in microfluidic systems, and multi-electrode array (MEA) network readouts in human 3D neural tissues. We then summarize best practices that improve cross-study comparability. These include reporting delivered versus nominal exposure, assessing recovery/mass balance and device/material interactions, applying proportional biological qualification (polarity, transporter/enzymatic competence, functional stability), defining a minimal comparable endpoint core, and preserving QIVIVE readiness in reporting. Finally, we outline near-term priorities for the field, including chronic low-dose and mixture designs, harmonized reference panels and acceptance criteria, and fit-for-purpose escalation to coupled OoC/MPS only when perfusion or organ–organ coupling is expected to change the interpretation. Full article

This review aims to explore the potential and mechanisms of selenium-biofortified probiotics as an innovative nutritional strategy for alleviating exercise-induced physiological stress. Exercise, particularly high-intensity or exhaustive exercise, triggers a cascade of physiological perturbations, including oxidative stress, inflammatory responses, gut barrier dysfunction, and muscle damage. Traditional single-nutrient strategies, such as inorganic selenium or probiotic supplementation, are often limited by low bioavailability or a narrow scope of action. Selenium-biofortified probiotics are produced via microbial biotransformation, which converts inorganic selenium into bioavailable organic forms like selenoamino acids or selenium nanoparticles that are loaded onto active probiotic carriers. This creates a synergistic entity combining the bioactivity of selenium with the gut-modulating functions of probiotics. Their core mechanism involves establishing a multi-layered defense system: by providing substrate for key selenoproteins like glutathione peroxidase, they directly enhance endogenous antioxidant defenses; by modulating immune cytokine networks, they downregulate excessive post-exercise inflammation; through probiotic colonization and metabolites, they maintain intestinal epithelial barrier integrity, countering exercise-induced intestinal hyperpermeability; and via the gut–muscle axis, they may regulate muscle metabolism and repair. Animal studies provide evidence for improved exercise endurance and reduced damage markers, but human clinical trials show inconsistent results, highlighting the influence of study design, dosage, and individual baseline status. Future research requires high-quality, long-term human trials to elucidate specific molecular pathways and develop personalized application protocols, advancing this synergistic strategy toward precision sports nutrition. Full article