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Micronutrients and Bioactive Molecules: Their Development, Interaction, and Impact on...
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Micronutrients and Bioactive Molecules: Their Development, Interaction, and Impact on Human Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Micronutrients and Human Health".

Deadline for manuscript submissions: 25 November 2025 | Viewed by 1229

Special Issue Editor

Dr. Jiaqiang Huang

E-Mail Website
Guest Editor
Department of Nutrition and Health, China Agricultural University, Beijing 100193, China
Interests: selenium; selenoprotein; health; Se-rich products; antioxidant
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce a Special Issue of Nutrients entitled “Micronutrients and Bioactive Molecules: Their Development, Interaction, and Impact on Human Health”. Micronutrients (e.g., selenium, zinc, iron, and vitamins) and bioactive molecules (e.g., polysaccharides and polyphenols) play pivotal roles in maintaining human health and preventing diseases. While deficiencies in essential minerals like selenium remain a global nutritional challenge, leading to conditions such as cardiovascular disorders and cognitive decline, the broader spectrum of micronutrients and bioactive compounds warrants deeper exploration. These substances are primarily obtained through diet, where their forms, interactions, and bioavailability critically influence their physiological functions. This Special Issue aims to highlight innovative research on (1) the development and regulation of micronutrient-enriched and bioactive molecule-based products (e.g., Se-rich foods, polyphenol extracts, and polysaccharide formulations); (2) mechanistic insights into their roles in redox regulation, anti-inflammatory pathways, immune modulation, and metabolic health. Nutrient interactions, including synergistic or antagonistic effects between minerals, vitamins, and bioactive compounds (e.g., Se with vitamin E or polyphenols with gut microbiota); (3) clinical and translational studies evaluating their efficacy in preventing or managing chronic diseases (e.g., diabetes, neurodegenerative disorders, and cancer); and (4) technological innovations in relation to enhancing the bioavailability, stability, and sustainable production of these nutrients.

We welcome original research, reviews, and meta-analyses encompassing in vitro, animal, and human studies. Submissions addressing genetic, epigenetic, and metabolic aspects of nutrient utilization, as well as public health strategies for nutrient fortification, are strongly encouraged. Our goal is to foster interdisciplinary dialogue and advance the understanding of how micronutrients and bioactive molecules collectively contribute to health optimization.

Dr. Jiaqiang Huang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • micronutrients
  • bioactive molecules
  • selenium-rich products
  • polysaccharides
  • polyphenols
  • nutrient interactions
  • health promotion
  • disease prevention

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Published Papers (2 papers)

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Review

24 pages, 2509 KiB  
Review
Potential Applications and Risks of Supranutritional Selenium Supplementation in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Critical Review
by Chuanming Liu, Ke Chen, Zijian Xu, Lianshun Wang, Yinhua Zhu, Zhengquan Yu, Tong Li and Jiaqiang Huang
Nutrients 2025, 17(15), 2484; https://doi.org/10.3390/nu17152484 - 30 Jul 2025
Viewed by 200
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the most prevalent chronic diseases in the world, lacking specific pharmacological interventions or well-established treatments. MASLD involves intricate pathological mechanisms characterized by oxidative stress and robust inflammatory responses. Selenium, an essential trace element, plays [...] Read more.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the most prevalent chronic diseases in the world, lacking specific pharmacological interventions or well-established treatments. MASLD involves intricate pathological mechanisms characterized by oxidative stress and robust inflammatory responses. Selenium, an essential trace element, plays a critical role in antioxidation, regulation of inflammation, anticancer activity, and so on. Recent studies have reported that supplementation with selenium could alleviate MASLD and associated hepatic disorders, while excessive consumption may result in insulin resistance or even selenosis. Therefore, supranutritional selenium supplementation can be more suitable for the therapy and prevention of MASLD. This paper comprehensively reviews research about selenium and MASLD to highlight the potential applications and risks of supranutritional selenium supplementation in MASLD, following three steps: conducting a search, reviewing research articles and reviews, and discussing results. The keywords for the search include but are not limited to selenium, MASLD, supranutritional, hepatic diseases, selenoproteions, and selenium nanoparticles (SeNPs). We have reached the following conclusions: supranutritional selenium supplementation exhibits promising potential as a strategy to treat MASLD, but there are still some risks, depending on the dose and form of selenium; evaluating MASLD severity and selenium nutritional status accurately, as well as supplementing with superior forms of selenium (e.g., organic selenium and SeNPs), can further ensure the safety and efficacy of selenium supplementation. However, relationships between selenium homeostasis disorders and the occurrence and development of MASLD have not been fully elucidated. Methods for comprehensively assessing selenium status and mechanisms of selenosis require further investigation and research. Full article
(This article belongs to the Special Issue Micronutrients and Bioactive Molecules: Their Development, Interaction, and Impact on Human Health)
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18 pages, 3463 KiB  
Review
Advances in Isorhamnetin Treatment of Malignant Tumors: Mechanisms and Applications
by Chen Mei, Ying Liu, Xueze Lyu, Zhaoling Jiang, Zhenyi Liu, Yan Zhi, Xiaolong Xu and Hongjun Wang
Nutrients 2025, 17(11), 1853; https://doi.org/10.3390/nu17111853 - 29 May 2025
Cited by 1 | Viewed by 726
Abstract
Isorhamnetin (ISO) is a natural flavonoid compound that has become a main research topic in recent years due to its multitargeted antitumor properties. In this paper, we systematically review the molecular basis of the inhibition of malignant tumors by ISO, including through the [...] Read more.
Isorhamnetin (ISO) is a natural flavonoid compound that has become a main research topic in recent years due to its multitargeted antitumor properties. In this paper, we systematically review the molecular basis of the inhibition of malignant tumors by ISO, including through the regulation of the cell cycle, PI3K/AKT/mTOR pathway, MAPK pathway, apoptosis/autophagy-related pathways, and the tumor microenvironment. We also explore its synergistic effects with chemotherapy/targeted therapies and its potential for clinical translation. Experimental studies have shown that ISO can not only directly inhibit tumor proliferation by inducing tumor cell cycle arrest, mitochondria-dependent apoptosis, and endoplasmic reticulum stress, but also enhance antitumor immune responses by regulating the immune microenvironment. Pharmacokinetic studies have shown that novel delivery systems, such as nano-formulations, significantly enhance the bioavailability of ISO. Notably, ISO has demonstrated unique advantages in attenuating the nephrotoxicity of chemotherapeutic agents, protecting normal cells, and reversing tumor resistance. However, the optimal dosing regimen, dose–effect relationship, and cross-species applicability need to be further validated by large-scale preclinical animal experiments and clinical trials. This paper provides a theoretical basis for the development and application of ISO for the treatment of malignant tumors and highlights its potential value in animal models. Full article
(This article belongs to the Special Issue Micronutrients and Bioactive Molecules: Their Development, Interaction, and Impact on Human Health)
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