Search Results (106)

The development of cold atom interferometry (CAI) provides new opportunities for next-generation satellite gravity gradiometry missions. Compared with the electrostatic gradiometer onboard the GOCE satellite, CAI gradiometers exhibit white noise characteristics within the effective measurement bandwidth, enabling improved performance in the low-frequency range (<5 $\mathrm{m}\mathrm{E}/\sqrt{\mathrm{H}\mathrm{z}}$). However, the measurement cycle, including atom preparation, cooling, and laser interferometry, leads to a relatively longer sampling rate, which may limit observation performance. In this study, the impact of sampling rate on the performance of a spaceborne CAI gradiometer is systematically investigated. Closed-loop simulations were performed under different observation configurations, noise levels, and sampling rates. The results are evaluated in terms of static gravity field recovery accuracy and compared with those from the GOCE mission. The results indicate that, for single-axis observations, the $V_{\mathit{zz}}$ component in nadir pointing mode achieves the highest accuracy at the 5 $\mathrm{m}\mathrm{E}/\sqrt{\mathrm{H}\mathrm{z}}$ noise level, while at 0.1 $\mathrm{m}\mathrm{E}/\sqrt{\mathrm{H}\mathrm{z}}$ and a 1 s sampling interval, the accuracy improves by one order of magnitude compared to GOCE. For dual-axis observations, the combinations $V_{\mathit{xx}}+V_{\mathit{zz}}$ and $V_{\mathit{yy}}+V_{\mathit{zz}}$ in nadir pointing mode provide the best performance at 5 $\mathrm{m}\mathrm{E}/\sqrt{\mathrm{H}\mathrm{z}}$, and an improvement of up to one order of magnitude is achieved at 0.1 $\mathrm{m}\mathrm{E}/\sqrt{\mathrm{H}\mathrm{z}}$ with a 1 s sampling interval. For tri-axis observations, both pointing modes outperform GOCE across the full frequency band only at a 1 s sampling interval under 5 $\mathrm{m}\mathrm{E}/\sqrt{\mathrm{H}\mathrm{z}}$ noise. At 0.1 $\mathrm{m}\mathrm{E}/\sqrt{\mathrm{H}\mathrm{z}}$, all sampling configurations yield better results than GOCE, with the highest accuracy achieved in nadir pointing mode. These findings demonstrate the critical role of sampling rate in CAI-based gravity field recovery and provide useful guidance for the design of future spaceborne quantum gravity missions. Full article

The optimization of Fused Filament Fabrication (FFF) process parameters is commonly performed using room-temperature mechanical properties as the main decision criteria, while the temperature-dependent thermomechanical response of printed polymers is often not explicitly considered. This limitation is relevant for functional components intended to operate above room temperature, where stiffness retention and viscoelastic behavior may strongly affect service performance. This work proposes an experimental–statistical framework for selecting FFF parameters by integrating Design of Experiments (DoE), tensile testing, dynamic mechanical analysis (DMA), Analysis of Variance (ANOVA), the Entropy Weight Method (EWM) and the VIKOR method. Two materials with contrasting thermomechanical behavior were investigated: a high-performance semicrystalline polymer, Z-PEEK, and an elastomeric thermoplastic, TPU 95A. For each material, a DoE was defined to evaluate the influence of key printing parameters, and the manufactured specimens were characterized in terms of maximum tensile force, maximum deformation and storage modulus at selected temperatures. The ANOVA results showed a material-dependent influence of the processing parameters, with thermally driven parameters being especially relevant for Z-PEEK and deposition-related parameters having a stronger influence on TPU 95A. The EWM–VIKOR analysis identified the optimal Z-PEEK configuration as 400 °C extrusion temperature, 200 °C build plate temperature and 150 °C chamber temperature, whereas the optimal TPU 95A configuration corresponded to 225 °C extrusion temperature, 0.10 mm layer height, 50 mm/s printing speed and 80 °C build plate temperature. Overall, the results demonstrate that incorporating DMA-derived thermomechanical indicators into MCDM-based optimization provides a more application-oriented basis for FFF parameter selection than approaches based only on room-temperature mechanical properties. Full article

Background/Objectives: For the first time, water-soluble encapsulated forms of 20-hydroxyecdysone were synthesized as clathrate complexes with β-cyclodextrin. The derivatives included a ketoxime form (20-NOH), obtained by selective oximation of the C-6 carbonyl, and a triacetate form (3Ac-20E), obtained by regioselective acetylation of the C-2, C-3, and C-22 hydroxyl groups. Methods: The chemical structures of the obtained compounds were confirmed using spectroscopic methods, including ¹H and ¹³C NMR. The Z-configuration of the oxime in 20-NOH was established by the diagnostic upfield shift in the C-5 resonance (δ 36.0 ppm) relative to the parent compound (δ 51.4 ppm). Results: The antioxidant activity was evaluated using FRAP and DPPH assays. The β-cyclodextrin complexes were shown to exhibit significantly higher radical scavenging activity, with IC₅₀ values of <0.05 mg/mL compared to 0.24 mg/mL for the parent 20-hydroxyecdysone (20E). In the FRAP assay, the complexes demonstrated enhanced reducing capacity, with values of 3.452 ± 0.520 AAE/mL for the ketoxime form (20-NOH·β-CD) at a concentration of 0.75 mg/mL and 3.810 ± 0.279 AAE/mL for the acetate form (3Ac-20E·β-CD) at the same concentration, whereas the parent compound did not exceed 0.46 AAE/mL. In both in vitro and in vivo experiments, it was established that the investigated complexes demonstrated hepatoprotective properties, as evidenced by the normalization of biochemical parameters as well as the restoration of liver structure according to ultrasound and histological studies. The ketoxime-derived complex (20-NOH·β-CD) at a dose of 25 mg/kg demonstrates the greatest reduction in transaminase activity and MDA levels, indicating its high efficacy and the presence of an optimal therapeutic dose. In addition, the encapsulated forms demonstrated moderate antifungal activity against Candida albicans and bactericidal activity against four bacterial strains (MIC >10 mg/mL). Conclusions: The obtained results indicate that β-cyclodextrin complexes significantly enhance the biological activity of 20E and highlight the potential of these compounds for pharmaceutical applications. Full article

Utilizing a partitioning method based on equal (or unequal) probabilities—without incorporating the alpha-cluster (α-cluster) model—allows for the derivation of diverse topological configurations of nuclear fragments resulting from fragmentation. Subsequently, we predict the multiplicity distribution of nuclear fragments for specific excited nuclei, such as ${}^9\mathrm{Be}^{*}$, ${}^{12}\mathrm{C}^{*}$, and ${}^{16}\mathrm{O}^{*}$, which can be formed as nuclear remnants in electron–nucleus ($eA$) collisions at high energy. Based on the $\alpha$-cluster model, an $\alpha$-cluster structure may result in deviations in the multiplicity distributions of nuclear fragments with charge $Z=2$, compared to those predicted by the partitioning methods. Furthermore, in the framework of Tsallis statistics, the nonextensive generalized temperature, entropy index, and q-entropy are obtained from the multiplicity distribution of nuclear fragments with a given charge number. Our work shows that fragmentation of nuclear remnants in electron–nucleus collisions at high energy is a nonextensive process. Full article

Classical approaches to cryptography exhibit several limitations when applied to scenarios involving more than two users. The One-Time User Key (OTUK) meta-cryptographic model addresses these limitations by enabling multi-user encryption that is flexible, applicable to any cryptographic algorithm, and designed for systematic deployment without compromising system security. Each user possesses an individual key from which One-Time keys are derived; these keys feed a secret-sharing function ($\omega$) that establishes the multi-user encrypted channel. In this paper, we present a polynomial-based implementation of the $\omega$ function under a $(1,n)$ threshold model. The generated polynomial has roots at points corresponding to valid user keys and is mapped to the real encryption key. We provide a formal threat model, pseudocode for the complete protocol, and a detailed computational analysis across the numerical domains $\mathbb{N}$, $\mathbb{Z}$, and $\mathbb{R}$. Furthermore, we present experimental benchmarks measuring encryption/decryption speed, scalability up to 30 users, parameter sensitivity, and a comparative evaluation against Shamir’s Secret Sharing scheme. A systematic security analysis examines partial-information attacks, derivative-root distance margins, and brute-force resistance, demonstrating that the effective security margin remains above 245 bits for configurations of up to 30 users with 256-bit keys. The proposed method offers a concrete, efficient, and secure foundation for multi-user encrypted communication in domains such as IoT, public administration, and e-health. Full article

This study presents the dynamic characterization of a gas turbine blade manufactured from two different nickel-based superalloys: on the first hand, a superalloy called René 80 and, on the second hand, a directionally solidified (DS) nickel-based anisotropic superalloy, investigated during the validation phase of the development process. Starting from the original CAD geometry, precise and very detailed finite-element models were developed, progressively refined and modified, and consequently validated to ensure mesh-independent modal predictions. The study examines multiple possible sources of discrepancy between experimentally measured and numerically predicted natural frequencies, including geometric deviations, grouping of different interesting points, broach-block test configuration, material anisotropy, and the influence of internal rib turbulators. Statistical analyses of dimensional variations revealed no significant correlation with the observed frequency scatter, redirecting the investigation toward material behavior and modeling fidelity. The inclusion of turbulators in the finite-element model proved essential, reducing prediction errors for the first two modes by approximately 2–3%. For the DS superalloy, the effect of grain orientation was evaluated over permissible angular deviations (extremes were considered); however, no systematic and clear improvement in frequency prediction was observed. Finally, several tuning strategies were assessed, leading to an optimization procedure that simultaneously adjusted the elastic moduli $E_x$ and $E_z$, reducing modal frequency deviations to below 1% for the first two modes. The proposed methodology provides a robust and solid framework for the validation of turbine blade dynamic behavior across different materials and manufacturing conditions. Full article

Eupalinolide A (EA, Z-configuration) and Eupalinolide B (EB, E-configuration) are cis-trans isomeric sesquiterpenoid monomers isolated from Eupatorium lindleyanum DC. (Asteraceae). Although these compounds display anti-inflammatory and anti-tumor activities, their metabolite profiles and possible hepatotoxicity remain largely unknown. This study aimed to investigate the metabolic profiles of EA and EB in liver microsomes and clarify whether they undergo metabolic activation or detoxification. EA and EB were metabolically profiled in human liver microsomes (HLMs) via UPLC-Q-TOF-MS. A HepG2-HLM co-culture system was used to compare the hepatocyte toxicity of parent compounds and their hydrolysis, oxidation, and hydrolysis–oxidation metabolites, thus evaluating their metabolic detoxification pathways. Sixteen metabolites of EA and 19 of EB were identified, with hydrolysis being the predominant metabolic pathway for both isomers. Both compounds showed low hepatocyte toxicity and underwent metabolic detoxification mainly via hydrolytic and oxidative pathways. Notably, hydrolysis metabolites had significantly lower toxicity than oxidative products in HepG2 cells. These results suggest that EA and EB could present a relatively low risk of in vivo hepatotoxicity, which provides useful information for understanding the metabolic behavior and safety profile of these bioactive sesquiterpenoids. Full article

The continuous increase in power density of electronic devices imposes stringent requirements on the design of lightweight, high-efficiency heat sinks. To overcome the limitations of conventional single-gradient or monomaterial heat sinks—namely, their suboptimal heat-transfer efficiency and poor structural adaptability—this study proposes a dual-gradient, triply periodic minimal surface (TPMS)-based multimaterial heat sink architecture fabricated from CuCrZr and AlSi₇Mg. Thermal performance was quantified experimentally using infrared thermography, while the underlying flow-field mechanisms were investigated numerically via computational fluid dynamics (CFD) simulations employing the standard k–ε turbulence model. With the TPMS material volume ratio fixed at 3:3 (CuCrZr:AlSi₇Mg), the Z-axis gradient configuration P-Z4-5 delivered the best overall thermal performance, achieving a heat-transfer coefficient (HTC) of 1557.63 W·m⁻²·K⁻¹ and a thermal resistance as low as 1.83 K·W⁻¹ at an inlet velocity of 5 m·s⁻¹. In contrast, the Y-axis gradient configuration P-Y3-6 yielded the most uniform temperature distribution, exhibiting a maximum surface temperature difference of only 21.5 °C under the same inlet condition. Velocity and turbulence distribution analyses reveal that the dual-gradient design enhances both the narrow-tube effect and flow-induced disturbances; furthermore, increasing the inlet velocity from 5 m·s⁻¹ to 21.65 m·s⁻¹ significantly intensifies vorticity-driven fluid mixing. Among all configurations evaluated, P-Z4-5 exhibited the highest j/f factor (i.e., the ratio of Colburn j-factor to Fanning friction factor), followed by P-Z3.5-5.5 and P-Z3-6. These findings establish a promising new pathway for the development of high-performance, lightweight heat sinks tailored for next-generation high-power electronics. Full article

With the growing adoption of electric vehicles (EVs), vehicle-to-grid (V2G) technology has emerged as an effective means to enhance grid flexibility through functions such as frequency regulation and peak shaving. However, the integration of a large number of power electronic devices via V2G has also raised serious concerns about grid stability. This paper first introduces the circuit configuration of a bidirectional V2G energy conversion system and proposes a novel converter equivalent circuit, i.e., Y-type and Z-type equivalence. A unified small-signal model of the V2G system is then established. From this model, the mathematical expressions for the AC bus current and DC bus voltage under various operating conditions are derived, leading to a common denominator factor, termed the generalized stability factor $D(S)$. Unlike conventional methods that rely on Nyquist diagrams, the distribution of poles and zeros of $D(S)$ is intuitively identified by analyzing its magnitude-frequency and phase-frequency characteristics. The existence of zeros in $D(S)$ is used as the stability criterion for the system. Finally, a simulation model of a clustered V2G energy conversion system is developed. Through systematic reduction in the DC-side capacitance in four distinct operational scenarios, our simulations successfully predicted and validated the emergence of characteristic oscillations at 870 Hz, 730 Hz, 843 Hz, and 893 Hz. This demonstrates the efficacy of the proposed stability criterion across various operating conditions. Full article

This paper presents a compact mixed-mode first-order universal filter based on a single voltage differencing current conveyor (VDCC), which can function in all four possible operation modes, i.e., voltage mode (VM), trans-admittance mode (TAM), current mode (CM), and trans-impedance mode (TIM). The proposed configuration requires only two grounded resistors and one floating capacitor, which contributes to a low component count, facilitates integration, and allows for the electronic tunability of the pole frequency through the transconductance gain of the VDCC. This work also demonstrates two practical biomedical applications: an electrocardiogram (ECG) acquisition system utilizing the VM low-pass filter for noise suppression and a bioimpedance (BioZ) measurement system employing the proposed configuration-based CM oscillator circuit as a sinusoidal excitation source. The performance validation confirms the accuracy of impedance extraction and the preservation of waveforms using tissue-equivalent models. The results demonstrate that the proposed VDCC-based filter offers a compact, power-efficient, and versatile analog signal-processing solution suitable for modern biomedical instrumentation. Full article

With the increasing power output of aero-engines, combustor hot-gas mass flow rate and temperature continue to rise, posing more severe challenges to combustor structural cooling design. To enhance the film-cooling performance of the Z-profile feature in a reverse-flow combustor, this study performs a multi-parameter numerical optimization by integrating computational fluid dynamics (CFD), a radial basis function neural network (RBFNN), and a genetic algorithm (GA). The hole inclination angle, hole pitch, row spacing, and the distance between the first-row holes and the hot-side wall are selected as design variables, and the area-averaged adiabatic film-cooling effectiveness over a critical downstream region is adopted as the optimization objective. The RBFNN surrogate model trained on 750 CFD samples exhibits high predictive accuracy (correlation coefficient (R > 0.999)). The GA converges after approximately 50 generations and identifies an optimal configuration (Opt C). Numerical results indicate that Opt C produces more favorable vortex organization and near-wall flow characteristics, thereby achieving superior cooling performance in the target region; its average adiabatic film-cooling effectiveness is improved by 7.01% and 9.64% relative to the reference configurations Ref D and Ref E, respectively. Full article

The Loop-Back Quantum Key Distribution (LB-QKD) protocol establishes a bidirectional architecture in which a single photon travels forth and back through the same optical channel. Unlike conventional one-way schemes such as BB84, Alice performs both state preparation and measurement, while Bob acts as a passive polarization modulator and reflector. This design eliminates detectors at Bob’s side, minimizes synchronization requirements, and enables compact, low-power implementations suitable for quantum-mobile and IoT platforms. An extended three-basis configuration $\{X,Y,Z\}$ is introduced, preserving the simplicity of the two-basis scheme while improving noise tolerance through enhanced orthogonality-based filtering. Analytical modeling shows that the effective protocol error decreases from $E_{\mathrm{protocol}}^{\left(2\right)}=e/2$ to $E_{\mathrm{protocol}}^{\left(3\right)}=e/3$, achieving a 33% improvement in noise resilience. Despite its slightly lower sifting efficiency ($\eta =1/6$), the total information gain reaches $G=0.26$ bits per pulse, maintaining post-sifting throughput comparable to BB84. The protocol doubles the tolerable QBER of conventional QKD, sustaining secure operation up to $22\%$ for two bases and approximately $47.58\%$ for three bases. Its passive, self-verifying architecture enhances resistance to man-in-the-middle, photon-number-splitting, and side-channel attacks, providing a scalable and energy-efficient framework for secure key distribution and authentication in next-generation mobile and distributed quantum networks. Full article

The review is focused on dictyopterenes A, B, C, and D found in marine algae, covering their (a) distribution; (b) methods of isolation and identification; (c) absolute configuration; and (d) biosynthesis considerations. Dictyopterenes A and B are usually present in high amounts in Dictyopteris spp. Dictyopterene A was found to be abundant in D. prolifera, D. undulata, D. latiscula, D. polypodioides, and D. membranacea. Dictyopterene B (hormosirene) was found as the major compound in D. plagiogramma, D. australis, Hormosira banksii, D. potatorum, D. willana, D. antarctica, Xiphophora chondrophylla, X. gladiata, Scytosiphon lomentaria, Colpomenia peregrina, and Haplospora globosa. Dictyopterene C (dictyotene) was a major compound in D. undulata, D. prolifera, D. membranacea, Gomphonema parvulum, Amphora veneta, Phaeodactylum tricornutum, and D. vermicularis. Dictyopterene D (ectocarpene) was present in Ectocarpus siliculosus, Analipus japonicus, D. prolifera, D. undulata, and Sargassum linifolium. The following enantiomers were found: (1S,2R)-dictyopterene A, (1R,2R)-dictyopterene B, (1S,2S)-dictyopterene B, (1S,2R)-dictyopterene B, (R)-dictyopterene C, and (S)-dictyopterene D. In marine algae, C₁₁-hydrocarbons are derived from C₂₀ polyunsaturated fatty acids by the oxidative cleavage via, e.g., 9-hydroperoxyicosa-(5Z,7E,11Z,14Z,17Z)-pentaenoic acid. An alternative biosynthetic pathway for dictyopterene A and B via the proposed intermediates (S)-dictyoprolenols was considered by oxidative cleavage of hydroperoxyicosatetraenoic acid. Full article

The efficient degradation of antibiotics in pharmaceutical wastewater remains a critical challenge against environmental contaminants. Conventional photocatalysts face potential limitations such as narrow visible-light absorption, rapid carrier recombination, and reliance on precious metal cocatalysts. This review investigates the coordination structure of MXene as a cocatalyst to synergistically enhance photocatalytic antibiotic degradation efficiency and the coordination structure modification mechanisms. MXene’s tunable bandgap (0.92–1.75 eV), exceptional conductivity (100–20,000 S/cm), and abundant surface terminations (-O, -OH, -F) enable the construction of Schottky or Z-scheme heterojunctions with semiconductors (Cu₂O, TiO₂, g-C₃N₄), achieving 50–70% efficiency improvement compared to pristine semiconductors. The “electron sponge” effect of MXene suppresses electron-hole recombination by 3–5 times, while its surface functional groups dynamically optimize pollutant adsorption. Notably, MXene’s localized surface plasmon resonance extends light harvesting from visible (400–800 nm) to near-infrared regions (800–2000 nm), tripling photon utilization efficiency. Theoretical simulations demonstrate that d-orbital electronic configurations and terminal groups cooperatively regulate catalytic active sites at atomic scales. The MXene composites demonstrate remarkable environmental stability, maintaining over 90% degradation efficiency of antibiotic under high salinity (2 M NaCl) and broad pH range (4–10). Future research should prioritize green synthesis protocols and mechanistic investigations of interfacial dynamics in multicomponent wastewater systems to facilitate engineering applications. This work provides fundamental insights into designing MXene-based photocatalysts for sustainable water purification. Full article

The mechanism of the electrophilic addition between phenylacetylene and N-heterocyclic carbene borane (NHC–borane), initiated by di-tert-butyl peroxide (DTBP), was elucidated at the M06-2X-D3/ma-def2-TZVP level to yield the Z-configured product. The computational results show that DTBP undergoes homolysis to generate two t-BuO· radicals; subsequently, it undergoes an H-shift reaction with N-heterocyclic carbene borane to form the N-heterocyclic carbene boron radical. Then, it is added to phenylacetylene to obtain the product radical intermediate. Finally, the product is yielded via an H-shift reaction. Meanwhile, this paper also explores the formation pathways of relevant byproducts. Structural analysis of the reaction reveals that weak interactions have a significant impact on the selectivity of the Z-configuration of the product. In addition, electron spin density contour maps are used to explain the electron distribution and reaction sites during the reaction process. This paper will provide relevant theoretical support for this type of addition reaction. Full article