Drug Metabolism and Toxicological Mechanisms—2nd Edition
A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Drugs Toxicity".
Deadline for manuscript submissions: 10 April 2026 | Viewed by 2245
Special Issue Editors
Interests: cellular and computational toxicology
Special Issues, Collections and Topics in MDPI journals
Interests: natural products analysis; pharmacological research; nuclear receptor function; metabolic diseases
Special Issues, Collections and Topics in MDPI journals
Interests: drug toxicology; computational toxicology; epitranscriptomics; RNA modification
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Absorption, distribution, metabolism, and excretion (ADME) processes are of great importance in understanding how the body disposes and responds to drugs. These processes play a pivotal role in assessing the efficacy and safety of drugs, while also enabling the prediction of potential adverse reactions or toxicities. A parent drug can undergo biotransformation induced by drug-metabolizing enzymes, leading to the formation of either toxic metabolites (metabolic activation) or non-toxic metabolites (detoxification). Thus, drug metabolism can be a key determinant of drug toxicity. Recently, new approach methodologies such as in silico methods, based on non-animal data, have been developed and applied in regulatory practices.
The first edition of the Special Issue on “Drug Metabolism and Toxicological Mechanisms” featured original research articles and comprehensive reviews that highlighted innovative methods and models. These included advancements in computational toxicology, the use of zebrafish as a model organism, and the application of multi-omics high-throughput sequencing technologies. These approaches were explored for their potential in enhancing toxicological risk assessment during the ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) processes of drug development. This Special Issue mainly focuses on drug metabolism and toxicological mechanisms. It extensively covers a range of topics, including drug metabolism, physiologically based pharmacokinetic (PBPK) modeling, toxicokinetics–toxicodynamics (TK–TD), ADME characterization, the identification and toxicity of metabolites, high-throughput pharmacokinetics (HT-PK), organ-specific toxicity, and toxicological mechanisms.
Prof. Dr. Qi Wang
Dr. Youbo Zhang
Dr. An Zhu
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- drug metabolism
- toxicity
- mechanism
- preclinical study
- clinical trial
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Related Special Issue
- Drug Metabolism and Toxicological Mechanisms in Toxics (13 articles)
