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8 Results Found

  • Article
  • Open Access
5 Citations
7,763 Views
13 Pages

Leukocyte Tyrosine Kinase (Ltk) Is the Mendelian Determinant of the Axolotl Melanoid Color Variant

  • Mirindi Kabangu,
  • Raissa Cecil,
  • Lloyd Strohl,
  • Nataliya Timoshevskaya,
  • Jeramiah J. Smith and
  • Stephen R. Voss

13 April 2023

The great diversity of color patterns observed among amphibians is largely explained by the differentiation of relatively few pigment cell types during development. Mexican axolotls present a variety of color phenotypes that span the continuum from l...

  • Review
  • Open Access
9 Citations
3,703 Views
16 Pages

7 October 2023

This review commemorates the 10-year anniversary of the discovery of physiological ligands Augα (Augmentor α; ALKAL2; Fam150b) and Augβ (Augmentor β; ALKAL1; Fam150a) for anaplastic lymphoma kinase (ALK) and leukocyte tyrosine k...

  • Article
  • Open Access
2 Citations
3,788 Views
11 Pages

RETRACTED: Tyrosine Kinase Inhibitors Target B Lymphocytes

  • Nikki Lyn Esnardo Upfold,
  • Pavlo Petakh,
  • Aleksandr Kamyshnyi and
  • Valentyn Oksenych

25 February 2023

Autoimmune disorders and some types of blood cancer originate when B lymphocytes malfunction. In particular, when B cells produce antibodies recognizing the body’s proteins, it leads to various autoimmune disorders. Additionally, when B cells of vari...

  • Article
  • Open Access
27 Citations
4,437 Views
13 Pages

Anti-Obesity Effects of Traditional and Commercial Kochujang in Overweight and Obese Adults: A Randomized Controlled Trial

  • A Lum Han,
  • Su-Ji Jeong,
  • Myeong-Seon Ryu,
  • Hee-Jong Yang,
  • Do-Youn Jeong,
  • Do-Sim Park and
  • Hee Kyung Lee

6 July 2022

Kochujang shows anti-obesity effects in cell and animal models. Kochujang is traditionally prepared via slow fermentation or commercially using Aspergillus oryzae. We analyze the anti-obesity effects of two types of Kochujang in overweight and obese...

  • Article
  • Open Access
9 Citations
3,294 Views
20 Pages

Design of New Potent and Selective Thiophene-Based KV1.3 Inhibitors and Their Potential for Anticancer Activity

  • Špela Gubič,
  • Louise Antonia Hendrickx,
  • Xiaoyi Shi,
  • Žan Toplak,
  • Štefan Možina,
  • Kenny M. Van Theemsche,
  • Ernesto Lopes Pinheiro-Junior,
  • Steve Peigneur,
  • Alain J. Labro and
  • Lucija Peterlin Mašič
  • + 3 authors

24 May 2022

The voltage-gated potassium channel KV1.3 has been recognized as a tumor marker and represents a promising new target for the discovery of new anticancer drugs. We designed a novel structural class of KV1.3 inhibitors through structural optimization...

  • Review
  • Open Access
16 Citations
5,077 Views
16 Pages

Novel Multitarget Therapies for Lung Cancer and Respiratory Disease

  • Masako Yumura,
  • Tatsuya Nagano and
  • Yoshihiro Nishimura

1 September 2020

In recent years, multitarget drugs for neurological diseases such as Alzheimer’s disease have been developed and well researched. Many studies have revealed that multitarget drugs are also useful for lung cancer and respiratory diseases. Pemetr...

  • Article
  • Open Access
15 Citations
4,658 Views
17 Pages

27 April 2022

The focus on online teaching and teachers’ digital competence (DC) has reached a new level following the emergence of COVID-19 and its dramatic influence on the educational industry, requiring teachers to be equipped with DC. However, there is...

  • Article
  • Open Access
4 Citations
1,022 Views
18 Pages

Comparative Analysis of Different Body Composition, Mucus Biochemical Indices, and Body Color in Five Strains of Larimichthys crocea

  • Hongjin Deng,
  • Quanyou Guo,
  • Banghong Wei,
  • Jiehui Zhong,
  • Mengyao Zheng,
  • Yao Zheng,
  • Na Lin and
  • Shengyang Zheng

25 June 2025

The large yellow croaker, or Larimichthys crocea, is highly prized for its golden color and nutritional content. The purpose of this study was to investigate the differences in body composition, mucus biochemical indices and body color in five strain...