Search Results (118)

This retrospective review traces personal encounters along the complex path of plant yellowing diseases—graft-transmissible disorders historically attributed to elusive viruses, but later linked to phloem-invading, wall-less bacteria known as Mollicutes. These include two plant-infecting genera: the cultivable Spiroplasma and the non-cultivable ‘Candidatus Phytoplasma’. A third group—the walled, psyllid-transmitted Candidatus Liberibacter—was later implicated in closely similar syndromes. This shift in understanding marked a major turning point in plant pathology, offering new insights into yellowing diseases characterized by stunting, decline, and poor or deformed growth. The review focuses on key syndromes: citrus little leaf disease (LLD), or citrus stubborn disease (CSD), caused by Spiroplasma citri; and several Mollicute -related disorders, including safflower phyllody, Bermuda grass yellowing, and papaya dieback (PDD) (Nivun Haamir), the latter linked to ‘Candidatus Phytoplasma australiense’. Despite differing causes and vectors, citrus LLD-CSD and PPD share an erratic, unpredictable pattern of natural outbreaks—sometimes a decade apart—hindering grower engagement and sustained control efforts. While scientific understanding has deepened, practical management remains limited. The recent global spread of Huanglongbing (HLB), caused by Candidatus Liberibacter species, underscores the urgent need for improved strategies to manage this resilient group of phloem-limited bacterial pathogens. Full article

Background: HER1 and HER2 are critical receptors involved in tumorigenesis and the development of targeted therapies for various carcinomas. However, most antibodies and drugs currently in development do not recognize murine orthologs, which restricts their evaluation in immunocompetent models. Methods: We generated nine tumor models through the lentiviral transduction of murine prostate (RM1), lung (3LL-D122), and breast (4T1) carcinoma cell lines, subsequently validating them in immunocompetent BALB/c and C57BL/6 hosts. Receptor expression and functionality were characterized using flow cytometry, immunoblotting, proliferation assays, and therapeutic sensitivity testing. Results: Transduced cells exhibited stable membrane expression of HER1/HER2 and ligand-induced phosphorylation, confirming receptor functionality. In all three tumor models generated, the expression of HER1 and/or HER2 significantly enhanced cell proliferation compared to parental lines. Furthermore, treatment with specific monoclonal antibodies and the tyrosine kinase inhibitor markedly reduced the viability of cells expressing HER1 and/or HER2, without affecting negative controls. Conclusions: These models provide a robust and reproducible platform for the preclinical evaluation of HER1/HER2-targeted therapies in immunocompetent hosts. Although the current model relies on subcutaneous implantation and does not fully replicate the native tumor microenvironment, it represents a crucial first step toward the development of orthotopic and immunologically relevant models for translational cancer research. Full article

The stability and mechanical properties of (TiZrHf)_1−x(AB)_x (AB = NbTa, NbMo, MoTa) refractory high-entropy alloys have been investigated by combining the first-principles with special quasi-random structure (SQS) method. It is found that with the increase in solute concentration x, the ΔH_mix of (TiZrHf)_1−x(AB)_x (AB = NbMo, MoTa) linearly decreases, whereas both ΔH_mix and ΔS_mix of (TiZrHf)_1−x(NbTa)_x increase initially and subsequently decrease, with the crossover occurring at x = 0.56. The ΔH_mix of (TiZrHf)_1−x(NbTa)_x and (TiZrHf)_1−x(AB)_x (AB = NbMo, MoTa) alloys are larger and lower than that of TiZrHf, respectively, while the ΔS_mix of all (TiZrHf)_1−x(AB)_x is larger than that of TiZrHf. The formation possibility parameter Ω of all (TiZrHf)_1−x(AB)_x (AB = NbMo, MoTa) first decreases sharply, followed by a gradual decrease. And the local lattice distortion (LLD) parameter δ remains relatively stable around x = 0.56 for all cases, after which it decreases sharply until x = 0.89. The δ value of (TiZrHf)_1−x(AB)_x is higher than that of TiZrHf for x < 0.56 but becomes lower beyond this composition. The valence electron concentration (VEC), a possible indicator for a single-phase solution, of (TiZrHf)_1−x(AB)_x increases nearly linearly, while the formation energy ΔH_f of (TiZrHf)_1−x(AB)_x shows the opposite tendency, except for (TiZrHf)_0.67(NbTa)_0.33. Furthermore, the VEC of all (TiZrHf)_1−x(AB)_x alloys increases, whereas their ΔH_f decreases compared to that of TiZrHf. The ideal strength σ_p of (TiZrHf)_1−x(AB)_x increases linearly, reaching approximately 2.12 GPa. The bulk modulus (B), elastic modulus (E), and shear modulus (G) also exhibit linear increases, and their values in all (TiZrHf)_1−x(AB)_x alloys are higher than those of TiZrHf, with some exceptions. The Cauchy pressure (C₁₂–C₄₄) and Pugh’s ratio G/B of all (TiZrHf)_1−x(AB)_x alloys increase, whereas the Poisson’s ratio ν exhibits the opposite trend. Moreover, the C₁₂–C₄₄ and G/B ratio of TiZrHf are lower and higher, respectively, than those of (TiZrHf)_1−x(AB)_x, and the ν of TiZrHf is lower than that of (TiZrHf)_1−x(AB)_x. This study provides valuable insights for the design of high-performance TiZrHf-based refractory high-entropy alloys. Full article

Crawling is an almost universal stage of locomotor development in infants; however, it is difficult to quantify using typical motion analysis techniques. The crawling stage therefore has underutilized potential to assess development and detect deviations or abnormalities. This study measured longitudinal weightbearing asymmetries in typically developing (TD) crawling children and compared this population to children with limb loss or limb differences (LLD) using a pressure-sensing mat. The LLD group bore significantly more weight using their arms vs. their legs than the TD group (p < 0.001), but even in cases of unilateral limb loss, bilateral weightbearing symmetry was similar to TD, controlling for body mass and age (p = 0.570). As children in the TD group developed and gained body mass, their weight shifted significantly to their left side (η² = 0.050) and away from their arms and toward their legs (η² = 0.255). The results provide insight into the biomechanical development of TD infant crawling, and the ways in which an atypically developing population manages weightbearing during crawling. The establishment of symmetry data will be useful, as crawling can serve as an opportunity for earlier detection of neuromotor conditions such as cerebral palsy. Furthermore, insight into the crawling patterns of children with limb loss and limb difference can inform prosthetic prescription and the need to consider a missing weight shift toward the legs as children develop. Full article

Background: Standard visual acuity (VA) is often preserved in early retinitis pigmentosa (RP), limiting its value as a marker of functional impairment. Alternative measures such as low-luminance deficit (LLD) and low-contrast deficit (LCD) may detect earlier changes in cone function. This study aimed to evaluate the diagnostic utility of these measures in RP patients under photopic and mesopic conditions. Methods: A prospective observational study was conducted on 57 RP patients and 54 age-matched controls. Binocular VA was assessed using ETDRS charts at 100% and 10% contrast under photopic (100 cd/m²) and mesopic (1 cd/m²) conditions. LLD and LCD scores were computed from VA differences across conditions. ROC curve analysis was used to determine diagnostic accuracy. Results: RP patients showed significant VA loss under reduced luminance and contrast (p < 0.001), independent of age. LLD under high contrast was reduced, while LLD under low contrast and LCD (both photopic and mesopic) were significantly higher than in controls. The mesopic LCD demonstrated the highest diagnostic capacity (AUC = 0.87), with a threshold of > 13 ETDRS letters yielding optimal sensitivity and specificity. Unlike standard VA, mesopic LCD correlated with functional symptoms and was unaffected by age. Conclusions: Low-contrast VA under mesopic conditions is a simple, reproducible, and sensitive marker for early visual dysfunction in RP. A difference > 13 ETDRS letters may serve as a clinically relevant threshold for disease monitoring and early detection in retinal dystrophies. Full article

Introduction: Instability following total hip arthroplasty (THA) remains a challenging complication. Dual-mobility (DM) hip components are aimed at improving joint stability by increasing the head-neck ratio and jump distance. However, data regarding the efficacy of these implants in the trauma setting are scarce. This study aimed to compare the dislocation rates of DM bearings with conventional THA in patients undergoing primary THA for the treatment of hip fractures. Methods: We retrospectively reviewed all patients who underwent THA for hip fractures between the years 2010–2022 and had a minimum follow-up of two years. Patient demographics and radiographic parameters, including cup version, leg length discrepancy (LLD) and femoral horizontal offset, were compared between patients who received DM bearings and patients who received conventional THA. Dislocation and revision surgery rates were also compared between the groups. Results: The study included 570 patients who met inclusion criteria, of which 82 patients were in the DM bearings group and 488 patients were in the conventional THA group. Baseline demographics and comorbidity profiles were comparable between the groups. Cup anteversion was significantly lower in the DM group (11.1° vs. 14.1°; p = 0.006), while no significant differences were observed in LLD nor femoral offset between the groups (p = 0.38, p = 0.69, respectively). Dislocation rates were similar between the DM and conventional THA groups (1.2% vs. 1.02%, respectively; p = 0.54). Furthermore, revision rates were similar between DM and conventional THA (1.22% vs. 2.87%, respectively; p = 0.387). Conclusions: While no significant differences in dislocation rates were observed between dual-mobility and conventional THA bearings, the significantly lower cup anteversion suggests a potential improvement in acetabular safe zone positioning, this could reflect a broader margin for error in implant positioning. Further prospective studies are needed to elucidate the biomechanical advantages of DM bearings in patients with hip fractures. Full article

Background: Vascular dysfunction is increasingly recognized as a shared contributor to both cognitive impairment and late-life depression (LLD). However, the combined diagnostic value of cerebral hemodynamics, neuroimaging markers, and neuropsychological outcomes remains underexplored. This study aimed to investigate the associations be-tween transcranial Doppler (TCD) ultrasound parameters, cognitive performance, and depressive symptoms in older adults with mild cognitive impairment (MCI) and LLD. Importantly, we evaluated the integrative value of TCD-derived indices alongside MRI-confirmed white matter lesions (WMLs) and standardized neurocognitive and affective assessments. Methods: In this cross-sectional study, 96 older adults were enrolled including 78 cognitively unimpaired individuals and 18 with MCI. All participants underwent structured clinical, neuropsychological, and imaging evaluations including the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Geriatric Depression Scale (GDS-15), MRI-based Fazekas scoring of WMLs, and TCD ultrasonography of the middle cerebral artery. Hemodynamic variables included mean blood flow velocity (MBFV), end-diastolic velocity (EDV), pulsatility index (PI), and resistive index (RI). Logistic regression and receiver operating characteristic (ROC) analyses were used to identify independent predictors of MCI. Results: Participants with MCI showed significantly lower MBFV and EDV, and higher PI and RI (p < 0.05 for all) compared with cognitively unimpaired participants. In multivariate analysis, lower MBFV (OR = 0.64, p = 0.02) and EDV (OR = 0.70, p = 0.03), and higher PI (OR = 3.2, p < 0.01) and RI (OR = 1.9, p < 0.01) remained independently associated with MCI. ROC analysis revealed excellent discriminative performance for RI (AUC = 0.919) and MBFV (AUC = 0.879). Furthermore, PI correlated positively with depressive symptom severity, while RI was inversely related to the GDS-15 scores. Conclusions: Our findings underscore the diagnostic utility of TCD-derived hemodynamic parameters—particularly RI and MBFV—in identifying early vascular contributions to cognitive and affective dysfunction in older adults. The integration of TCD with MRI-confirmed WML assessment and standardized cognitive/mood measures represents a novel and clinically practical multi-modal approach for neurovascular profiling in aging populations. Full article

Background and Objective: This study presents a combined osteometric and biomechanical analysis of a Korean female cadaver exhibiting bilateral lower limb bone asymmetry with abnormal curvature and callus formation on the left femoral midshaft. Methods: To investigate bilateral bone length differences, osteometric measurements were conducted at standardized landmarks. Additionally, we developed three gait models using Meta Motivo, an open-source reinforcement learning platform, to analyze how skeletal asymmetry influences stride dynamics and directional control. Results: Detailed measurements revealed that the left lower limb bones were consistently shorter and narrower than their right counterparts. The calculated lower limb lengths showed a bilateral discrepancy ranging from 39 mm to 42 mm—specifically a 6 mm difference in the femur, 33 mm in the tibia, and 36 mm in the fibula. In the gait pattern analysis, the normal model exhibited a straight-line gait without lateral deviation. In contrast, the unbalanced, non-learned model demonstrated compensatory overuse and increased stride length of the left lower limb and a tendency to veer leftward. The unbalanced, learned model showed partial gait normalization, characterized by reduced limb dominance and improved right stride, although directional control remained compromised. Conclusions: This integrative approach highlights the biomechanical consequences of lower limb bone discrepancy and demonstrates the utility of virtual agent-based modeling in elucidating compensatory gait adaptations. Full article

Background: A precise radiographic evaluation of adolescent idiopathic scoliosis (AIS) is essential for effective treatment planning and follow-up. The pelvic axial rotation (PAR) and horizontal balance of the pelvis are critical factors to consider throughout the treatment and monitoring of AIS. While some previous studies have examined spinal curvature in relation to PAR direction and the direction of the major curve (DMC) in AIS patients, this study aims to explore the relationship between scoliosis morphology, pelvic axial rotation (PAR), and the direction of the major curve in patients with adolescent idiopathic scoliosis. Methods: Radiographic images of 397 patients diagnosed with AIS between 2023 and 2024 at a Tertiary Referral Hospital were retrospectively evaluated. Morphological and morphometric measurements, including sex, Lenke and Risser classifications, lower leg discrepancy, Cobb angle, PAR direction, and major curvature direction, were performed. Results: The mean age of the 397 patients (246 female, 151 male) was 14.47 ± 2.29. There is no significant correlation between PAR and DMC (p = 0.919). No significant differences were found in terms of sex (p = 0.603). Regardless of the PAR direction, major curvature was more common on the left side (57.7%). Furthermore, a positive correlation was noted between the Cobb angle and LLD. Conclusions: Our study contributes to a growing body of literature questioning the deterministic role of PAR in AIS. While previous reports have emphasized the directional correlation between the pelvis and spinal curvature, our findings suggest that pelvic rotation may not be a reliable indicator of curve direction in all patients. This highlights the complexity of AIS biomechanics and underscores the need for individualized radiographic and clinical evaluation rather than a reliance on generalized compensatory models. Full article

There are numerous methods available for evaluating leg length discrepancy (LLD), ranging from classic clinical techniques to advanced systems based on sophisticated and expensive equipment, as well as rudimentary manual adjustment mechanisms for the prosthesis by specialists. However, unilateral amputee patients often face difficulties in accessing these solutions. They either lack the necessary equipment or do not have a medical specialist available to assist them in preventing postural imbalances. This study proposes the first smartphone-based computer vision system that evaluates and automatically compensates for leg length discrepancy in transtibial prostheses, offering a low-cost, accessible, and fully autonomous alternative to existing solutions. The method was tested using complex metrological systems. The application of the proposed method demonstrated its effectiveness in correcting simulated LLD for various values. Experimental validation demonstrated the system’s ability to restore symmetry in simulated LLD cases within the 1–10 mm range, achieving a relative compensation error of 2.44%. The proposed method for correcting LLD, based on computer vision and integrated into a smartphone, represents a significant advancement in restoring symmetry for unilaterally amputated patients. This technology could provide an accessible, efficient solution, thereby reducing the need for frequent prosthetist visits and enhancing user autonomy. Full article

Body asymmetry is often analysed in the context of low back pain (LBP). To date, research has mainly focused on the general relationships between asymmetry and pain, with less attention paid to issues related to pressure distribution and its potential impact on the occurrence of LBP. The aim of this study was to compare biomechanical parameters in people with anatomical leg length discrepancy with and without LBP to identify overloads that may lead to pain. Early detection of common abnormalities in these parameters in both groups may influence the early prevention of 0LBP in the course of LLD. Materials and methods: This study included 60 patients with diagnosed LLD, of whom 30 had LBP (group 1, NP) and 30 were pain-free (group 2, NwP). Body weight distribution during standing and walking was analysed using pedobarography. The analysis was carried out in two stages, the first being the analysis of the biomechanical parameters for the whole study population, for group 1 with LBP and group 2 without LBP, while the second stage focused on the main issue, i.e., the comparison of the group with LBP with the group without LBP. The study included standing and walking tests. Left–right pressure distribution and ground contact time were analysed. In addition, the angle of foot abduction was analysed to indirectly assess compensatory mechanisms resulting from the asymmetry. Results: The standing test showed significantly greater pressure on the longer limb (p = 0.022) in the whole study population (N = 60). When divided into groups, it was found that in those with LBP (NP = 30), the difference was not statistically significant (p = 0.359), whereas in those without pain (NwP = 30), the pressure on the longer limb was significantly greater (p = 0.002). No differences were found between the groups in the comparative analysis. The angle of foot abduction was greater than normal across the study population (N = 60), with greater values in the shorter limb (12.83° vs. 11.04°), which was close to significance (p = 0.065). The group with LBP (NP = 30) showed a similar trend, also close to statistical significance (p = 0.054), with significantly higher values of abduction angle in both legs compared to the group without LBP (NwP = 30). In the walking test, the left–right load distributions were significantly dispersed. The mean pressure on the longer limb was significantly higher in group 1 (NP = 30) (p = 0.031), whereas this difference was not statistically significant in group 2 (NwP = 30). For mean peak pressure, there were no significant differences in any of the groups tested. In addition, the mean ground contact time during gait was longer for the longer limb in the whole study population (N = 60) (938.8 ms vs. 915 ms), but again, this difference did not reach statistical significance (p = 0.305). Comparative analysis showed no differences between the groups. Conclusions: This study showed that in people with anatomical LLD, both with and without LBP, most parameters reflected marked asymmetries in peak and mean pressures and abduction angles. A prolongation of ground contact time has also been shown, and even though some parameters were not statistically significant, it is important to note the high dispersion of left–right loading, which provides information on body load asymmetries in patients with anatomical LLD. Given that there were no differences between the groups for most of the parameters, it is important for both clinical practice and further research that the abnormalities observed in both groups (NP = 30, NwP = 30) may have been a significant predictor of the development of LBP, as the abnormalities preceded the onset of pain. This should be taken into account in diagnostic and preventive measures. Full article

Traditional coal quality assessment methods rely exclusively on the laboratory testing of physical samples, which impedes detailed stratigraphic evaluation and limits the integration of intelligent precision mining technologies. To resolve this challenge, this study investigates geophysical logging as an innovative method for coal quality prediction. By integrating scanning electron microscopy (SEM), X-ray analysis, and optical microscopy with interdisciplinary methodologies spanning mathematics, mineralogy, and applied geophysics, this research analyzes the coal quality and mineral composition of the Shanxi Formation coal seams in northern Jiangsu, China. A predictive model linking geophysical logging responses to coal quality parameters was established to delineate relationships between subsurface geophysical data and material properties. The results demonstrate that the Shanxi Formation coals are gas coal (a medium-metamorphic bituminous subclass) characterized by low sulfur content, low ash yield, low fixed carbon, high volatile matter, and high calorific value. Mineralogical analysis identifies calcite, pyrite, and clay minerals as the dominant constituents. Pyrite occurs in diverse microscopic forms, including euhedral and semi-euhedral fine grains, fissure-filling aggregates, irregular blocky structures, framboidal clusters, and disseminated particles. Systematic relationships were observed between logging parameters and coal quality: moisture, ash content, and volatile matter exhibit an initial decrease, followed by an increase with rising apparent resistivity (LLD) and bulk density (DEN). Conversely, fixed carbon and calorific value display an inverse trend, peaking at intermediate LLD/DEN values before declining. Total sulfur increases with density up to a threshold before decreasing, while showing a concave upward relationship with resistivity. Negative correlations exist between moisture, fixed carbon, calorific value lateral resistivity (LLS), natural gamma (GR), short-spaced gamma-gamma (SSGG), and acoustic transit time (AC). In contrast, ash yield, volatile matter, and total sulfur correlate positively with these logging parameters. These trends are governed by coalification processes, lithotype composition, reservoir physical properties, and the types and mass fractions of minerals. Validation through independent two-sample t-tests confirms the feasibility of the neural network model for predicting coal quality parameters from geophysical logging data. The predictive model provides technical and theoretical support for advancing intelligent coal mining practices and optimizing efficiency in coal chemical industries, enabling real-time subsurface characterization to facilitate precision resource extraction. Full article

Background/Objectives: Early integration of palliative care (PC) improves outcomes for patients with life-limiting diseases (LLDs). This study evaluated the effectiveness of the Palliative Care and Rapid Emergency Screening (P-CaRES) tool—originally developed for emergency settings—in identifying unmet PC needs among patients admitted to internal medicine wards. Methods: In this retrospective study, the P-CaRES tool was applied to medical records of patients with LLDs. Demographic and clinical data were extracted from charts. Logistic regression identified predictors of PC receipt; survival was analyzed using Kaplan–Meier estimates and log-rank tests. Results: Among 2509 patients screened, 631 (23.9%) had at least one LLD. Of these, 451 (71.5%) were identified as having PC needs. However, only 132 (20.9%) received PC services—126 with documented need and 6 without. Advanced cancer (OR = 6.46, p < 0.001), a positive response to the surprise question (OR = 4.88, p = 0.008), and frequent hospitalizations (OR = 2.24, p < 0.001) predicted PC receipt. Median survival declined with increasing disease burden (10 vs. 372 days for patients with ≥3 vs. 1 LLD), unmet PC needs (85 vs. 1383 days), and a “yes” response to the surprise question (79 vs. 1598 days) (all p < 0.001). Conclusions: The P-CaRES tool effectively identified PC needs in patients with LLDs, including those with cancer. Clinical indicators such as frequent hospital admissions, a positive response to the surprise question, and multimorbidity predicted both the need for PC and shorter survival. Nonetheless, substantial gaps existed between identified needs and PC delivery—especially for non-cancer patients. Structured screening and timely referrals may bridge this gap and improve care for seriously ill individuals. Full article

Background/Objectives: Total hip arthroplasty (THA) is a widely performed procedure to alleviate pain and improve function in patients with hip disorders. However, leg length discrepancy (LLD) remains a prevalent complication. LLD can cause gait disturbances, back pain, postural imbalance, and patient dissatisfaction, along with significant medico-legal implications. This review examines the evaluation, management, and medico-legal aspects of LLD. Methods: The review analyzed literature on the prevalence, evaluation methods, and management strategies for LLD in THA. Radiographic and clinical assessment tools were considered, alongside factors such as pelvic obliquity and pre-existing conditions. The importance of preoperative planning, intraoperative techniques (including computer-assisted methods), and comprehensive documentation was evaluated to address both clinical and legal challenges. Results: The review shows that leg length discrepancy (LLD) following total hip arthroplasty (THA) occurs in 3% to 30% of cases, with mean values ranging from 3 to 17 mm. LLD may result from anatomical or procedural factors, and effective evaluation requires both radiographic imaging and clinical assessment. Preoperative planning plays a critical role in accurately assessing anatomical parameters and selecting appropriate prosthetic components to preserve or restore limb length symmetry. Advanced intraoperative techniques, including computer-assisted surgery, help reduce LLD incidence. While some complications may be unavoidable, proper documentation and patient communication, particularly regarding informed consent, are essential to mitigate medico-legal risks Conclusions: LLD after THA requires a multidimensional approach incorporating clinical, radiological, biomechanical, and legal considerations. Effective preoperative and intraoperative strategies, combined with robust communication and documentation, are essential to minimize LLD and its associated risks. A focus on precision and patient-centered care can improve outcomes and reduce litigation. Full article

Background/Objectives: Morphological spinal alterations in adolescents, including idiopathic scoliosis (IS) and postural scoliotic attitudes (paramorphisms), may be associated with leg length discrepancy (LLD) and breast asymmetry (BA). This study aimed to assess the prevalence and characteristics of LLD and BA in adolescents with spinal paramorphisms and dysmorphisms (IS), and to explore associations between these asymmetries and spinal curve features. Methods: A cross-sectional observational study was conducted. Adolescents aged 10–18 years were included. LLD was measured clinically via direct tape measurement and, when necessary, ultrasound. BA was assessed via visual inspection. Spinal deformities were characterized via clinical and radiological examination. Results: Among the 44 participants, 26 (60%) had IS and 18 (40%) had postural scoliotic attitudes. LLD was present in 79.5% (mean 0.7 ± 0.6 cm; all mild). BA was observed in 14% of the sample. LLD was more frequent in IS (87%) than in postural scoliotic attitudes (72%). In lumbar postural curves, the shorter limb was consistently ipsilateral to the curve convexity. In IS, no consistent association was found between LLD and curve characteristics. BA was slightly more prevalent in IS (19%) than postural scoliotic attitudes (17%), with no consistent pattern relative to curve convexity. Conclusions: Mild LLD is common in adolescents with spinal asymmetries and reflects general population norms. While LLD may influence compensatory postural curves, it does not appear to affect IS curve patterns or severity. BA is more frequent in IS, but shows variable association with curve features. Considering LLD and BA prevalence in adolescents with spinal asymmetries routine assessment is warranted, though their impact on IS progression is limited. Full article