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10 Results Found

  • Article
  • Open Access
22 Citations
3,736 Views
13 Pages

Praeruptorin B Mitigates the Metastatic Ability of Human Renal Carcinoma Cells through Targeting CTSC and CTSV Expression

  • Chia-Liang Lin,
  • Tung-Wei Hung,
  • Tsung-Ho Ying,
  • Chi-Jui Lin,
  • Yi-Hsien Hsieh and
  • Chien-Min Chen

Renal cell carcinoma (RCC) is the most common adult kidney cancer, and accounts for 85% of all cases of kidney cancers worldwide. Praeruptorin B (Pra-B) is a bioactive constituent of Peucedanum praeruptorum Dunn and exhibits several pharmacological a...

  • Article
  • Open Access
4 Citations
2,567 Views
13 Pages

3 September 2024

In this paper, we first build the 3D model of coaxial TSV(CTSV), RDL, and bump of the CTSV interconnect, and extract the equivalent circuit model of each part. Then, we get the S-parameters of the 3D and equivalent circuit model of the CTSV interconn...

  • Article
  • Open Access
9 Citations
3,839 Views
17 Pages

Critical Role of Cathepsin L/V in Regulating Endothelial Cell Senescence

  • Chan Li,
  • Zhaoya Liu,
  • Mengshi Chen,
  • Liyang Zhang,
  • Ruizheng Shi and
  • Hua Zhong

26 December 2022

The senescence of vascular endothelial cells (ECs) is characterized as a hallmark of vascular aging, which leads to the initiation, progress, and advancement of cardiovascular diseases. However, the mechanism of the ECs senescence remains elusive. In...

  • Article
  • Open Access
6 Citations
2,821 Views
11 Pages

Efficient Thermal-Stress Coupling Design of Chiplet-Based System with Coaxial TSV Array

  • Xianglong Wang,
  • Jiaming Su,
  • Dongdong Chen,
  • Di Li,
  • Gaoliang Li and
  • Yintang Yang

25 July 2023

In this research, an efficient thermal-stress coupling design method for a Chiplet-based system with a coaxial through silicon via (CTSV) array is developed by combining the support vector machine (SVM) model and particle swarm optimization algorithm...

  • Article
  • Open Access
12 Citations
4,837 Views
20 Pages

Identification of Key Genes Associated with Progression and Prognosis of Bladder Cancer through Integrated Bioinformatics Analysis

  • Shiv Verma,
  • Eswar Shankar,
  • Spencer Lin,
  • Vaibhav Singh,
  • E. Ricky Chan,
  • Shufen Cao,
  • Pingfu Fu,
  • Gregory T. MacLennan,
  • Lee E. Ponsky and
  • Sanjay Gupta

25 November 2021

Bladder cancer prognosis remains dismal due to lack of appropriate biomarkers that can predict its progression. The study aims to identify novel prognostic biomarkers associated with the progression of bladder cancer by utilizing three Gene Expressio...

  • Article
  • Open Access
6 Citations
3,007 Views
13 Pages

OSucs: An Online Prognostic Biomarker Analysis Tool for Uterine Carcinosarcoma

  • Yang An,
  • Qiang Wang,
  • Fengjie Sun,
  • Guosen Zhang,
  • Fengling Wang,
  • Lu Zhang,
  • Yanan Li,
  • Weinan Ren,
  • Wan Zhu and
  • Xiangqian Guo
  • + 2 authors

3 September 2020

Background: Uterine carcinosarcoma (UCS) is a type of rare and aggressive tumor. The standard treatment for UCS involves surgical treatment followed by radiochemotherapy. Clinical outcomes of UCS patients are poor due to high metastasis and relapse r...

  • Article
  • Open Access
47 Citations
7,615 Views
21 Pages

Aminopeptidase Expression in Multiple Myeloma Associates with Disease Progression and Sensitivity to Melflufen

  • Juho J. Miettinen,
  • Romika Kumari,
  • Gunnhildur Asta Traustadottir,
  • Maiju-Emilia Huppunen,
  • Philipp Sergeev,
  • Muntasir M. Majumder,
  • Alexander Schepsky,
  • Thorarinn Gudjonsson,
  • Juha Lievonen and
  • Caroline A. Heckman
  • + 8 authors

26 March 2021

Multiple myeloma (MM) is characterized by extensive immunoglobulin production leading to an excessive load on protein homeostasis in tumor cells. Aminopeptidases contribute to proteolysis by catalyzing the hydrolysis of amino acids from proteins or p...

  • Article
  • Open Access
6 Citations
3,588 Views
18 Pages

22 October 2024

Diabetes remains a critical global public health challenge, posing a growing threat to human health and well-being. White tea is a lightly fermented tea and one of the six traditional tea categories in China. Owing to its rich content of bioactive co...

  • Article
  • Open Access
18 Citations
5,735 Views
21 Pages

10 September 2021

Predictive analytics using artificial intelligence is a useful tool in cancer research. A multilayer perceptron neural network used gene expression data to predict the lymphoma subtypes of 290 cases of non-Hodgkin lymphoma (GSE132929). The input laye...

  • Article
  • Open Access
885 Views
12 Pages

Identification of Deregulated Proteins in Mutated BRCA1/2 Breast and Ovarian Cancers for Vectorized Biologics

  • Adrián Sanvicente,
  • Cristina Nieto-Jiménez,
  • Esther Cabañas Morafraile,
  • Cristina Díaz-Tejeiro,
  • Vanesa García Barberán,
  • Pedro Pérez Segura,
  • Győrffy Balázs and
  • Alberto Ocaña

1 July 2025

Background: Administration of PARP inhibitors against breast and ovarian cancers with BRCA1 and BRCA2 mutations has shown clinical benefits in patients. However, these agents are also toxic and have a narrow therapeutic index. Objectives: In this wor...