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Article

10 Citations

5,705 Views

23 Pages

Comparative Evaluation of Gelatin and HPMC Inhalation Capsule Shells Exposed to Simulated Humidity Conditions

Sabrina Magramane,
Nikolett Kállai-Szabó,
Dóra Farkas,
Károly Süvegh and ,
Romána Zelkó and
István Antal
+ 1 author+ 0 author

Pharmaceutics2025, 17(7), 877;https://doi.org/10.3390/pharmaceutics17070877

3 July 2025

Background/Objectives: This study investigates the impact of high humidity (25 °C, 75% relative humidity) on gelatin and hydroxypropyl methylcellulose (HPMC) capsules used in dry powder inhalers (DPIs), focusing on moisture dynamics, structural r...

(This article belongs to the Section Physical Pharmacy and Formulation)

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Article

5 Citations

1,702 Views

20 Pages

Nanoparticle-Reinforced Electroless Composite Coatings for Pipeline Steel: Synthesis and Characterization

Biplab Baran Mandal,
Vikash Kumar,
Sovan Sahoo,
Buddhadeb Oraon and
Sumanta Mukherjee

Materials2025, 18(17), 3949;https://doi.org/10.3390/ma18173949

22 August 2025

Protective coatings are essential for extending the service life of components exposed to harsh conditions, such as pipes used in industrial systems, where wear and corrosion remain constant challenges. This study explores the development of a nano-s...

(This article belongs to the Section Advanced Nanomaterials and Nanotechnology)

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Article

14 Citations

6,283 Views

20 Pages

Predicting the Release Mechanism of Amorphous Solid Dispersions: A Combination of Thermodynamic Modeling and In Silico Molecular Simulation

Stefanie Walter,
Paulo G. M. Mileo,
Mohammad Atif Faiz Afzal,
Samuel O. Kyeremateng and ,
Matthias Degenhardt,
Andrea R. Browning and
John C. Shelley
+ 2 authors+ 0 author

Pharmaceutics2024, 16(10), 1292;https://doi.org/10.3390/pharmaceutics16101292

2 October 2024

Background: During the dissolution of amorphous solid dispersion (ASD) formulations, the drug load (DL) often impacts the release mechanism and the occurrence of loss of release (LoR). The ASD/water interfacial gel layer and its specific phase behavi...

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