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Small extracellular vesicles (sEVs), commonly referred to as exosomes, are nanoscale vesicles that mediate intercellular communication and represent promising biotechnological platforms for disease diagnosis, therapeutic intervention, and drug delive...
An artificial neural network (ANN)-based digital twin feed controller, aiming to optimise bioprocess performance, was implemented in fed-batch bioprocesses of Lactobacillus rhamnosus LRH30 for the production of biomass. The online data from several f...
Oat (Avena sativa L.) is generally considered a healthy and nutritious cereal and has gained further interest due to the generation of oat milk as an alternative nutritious beverage. However, during oat milling, about 20–30% hulls are produced....
Antioxidants play a crucial role in preventing and treating various diseases in both humans and animals, and the consumption of nutraceuticals represents a major source of these compounds. Among nutraceuticals, special attention is focused on honey,...
ADC-111 is an Antigen-1-targeting antibody–drug conjugate with approximately eight payloads conjugated to one monoclonal antibody. The primary mechanism of action of ADC-111 is payload-induced cytotoxicity after antigen–antibody binding-m...
With-No-Lysine Kinase 1 (WNK1) is an atypical serine/threonine kinase involved in ion homeostasis, blood pressure regulation, migration and proliferation. Its intrinsically disordered regions (IDRs) support dynamic phosphorylation patterns. Here, we...
Fabry disease is a rare genetic multisystemic lysosomal disease characterized by progressive cellular accumulation of globotriaosylceramide (GL-3) in various organs with specific cutaneous (angiokeratoma), neurological (pain), renal (proteinuria, chr...
Lisianthus (Eustoma grandiflorum) is an ornamental species of high commercial value due to its diverse flower colors and prolonged vase life. However, lisianthus propagation by seed is limited by its low germination rates and high genetic variability...
Background/Objectives: Pharmaceutical residues in human urine have raised serious concerns about the safe reuse of urine in agriculture. The current study investigates and compares the concentrations of pharmaceuticals in urine samples collected from...
Pan-Amazonian biodiversity represents an unexplored source of high-value compounds and renewable raw materials, particularly from the many plant species of the Amazon Forest. Although the legal framework for Amazonian resource exploitation is grounde...
Artificial intelligence (AI) is increasingly central to modern virus detection, particularly as metagenomic next-generation sequencing (mNGS) expands diagnostic and surveillance capabilities beyond targeted assays. This paper reviews how AI supports...
Plant proteins represent both important nutritional resources and reservoirs of encrypted bioactive peptide sequences. However, protein nutritional quality and peptide bioactivity are distinct properties: a favorable indispensable amino acid profile...
Exercise-induced reactive oxygen and nitrogen species (RONS) are not merely damaging by-products but essential components of signaling networks that support training adaptation. This narrative review examines how the Mediterranean diet (MedDiet) may...
Acid proteases can improve nitrogen availability during ethanol fermentation by hydrolysing feedstock proteins, but their catalytic performance at relatively low temperatures may be limited. In this study, an acid protease-producing Rhodotorula mucil...
High organic pollutant load and salinity pose major challenges for the biological treatment of industrial wastewater. This study evaluated an air-cathode microbial fuel cell (AC-MFC) inoculated with halophilic microorganisms for the simultaneous trea...
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Drug-resistant Klebsiella pneumoniae is a serious clinical problem, and bacteriophages are being investigated again as antibacterial agents. This study describes the phenotypic characterization and a preliminary in vivo evaluation of vB_Kpn_NIIPB-V00...
Vermicomposting has been shown to be a cost-effective and sustainable approach for improving the environmental safety of sewage sludge, yet it remains comparatively understudied at the industrial scale. This study investigates how vermicomposting wit...
Expedited programs accelerate the availability of gene therapy products but frequently leave uncertainties regarding efficacy at approval. How post-approval requirements are utilized to complement these specific evidence gaps remains unclear. To addr...
Background: Long-term biospecimen preservation requires sustained institutional investment in storage equipment, energy or cryogen, monitoring, maintenance, and inventory management. Although biobank economics and biospecimen utilization have been ex...
Corneal diseases are a major cause of blindness and visual impairment worldwide. Although conventional pharmacological therapies can alleviate mild to moderate corneal disorders, they often fail to restore vision in advanced disease, leaving corneal...
Cell and gene therapies (CGTs) have progressed from proof of concept to an established commercial pipeline, yet global translation remains constrained by fragmented regulatory frameworks; heterogeneous Chemistry, Manufacturing, and Controls (CMC) req...
Isolation of various groups of protein preparations is a crucial task in many areas of biochemical research. Creating an effective, simple and economically feasible system for recombinant protein production is highly valuable for both basic research...
Cellular identity determination and lineage tracing is a pivotal technique in modern biological research. Conceptually simple yet efficient cell labeling techniques offering broader applicability are warranted despite many methods requiring intricate...
Metabolic pathway design tools largely address reaction routes and enzyme choice, whereas a complementary set of questions—how pathway genes are arranged on bacterial chromosomes and whether co-directional neighborhoods can inform multi-gene co...
The guarana seed peel (GSP), an agroindustrial waste, was characterized for its chemical composition and evaluated for its antimicrobial activity as a potential source of antibacterial compounds for wastewater disinfection using UPLC-QTOF-MS analysis...
Glucoamylases are highly demanded by the industry for starch saccharification, which necessitates an increase in enzyme activity. To improve the activity of Aspergillus awamori VKPM F-1262 glucoamylase N181Q (AGAM), amino acid substitutions were made...
Moruga Hill Rice (MHR) is an African rice (Oryza glaberrima Steud.) brought to Trinidad by formerly enslaved African Americans and has been grown for many generations in Trinidad at subsistence and commercial scale. Despite its historical and agricul...
The present study provides the physicochemical and genomic characterization of three Escherichia bacteriophages (6phi8, 6phi10, and 6phi13) isolated from the commercial phage preparation “Sextaphag®”. For each bacteriophage, lytic act...
Raspberry ketone (RK) is a valuable natural flavor compound, but its extraction from plants is inefficient because of its low natural abundance. Microbial production of RK offers a promising alternative; however, insufficient availability of malonyl-...
The cohesin complex is a highly conserved, ring-shaped protein assembly that plays fundamental roles in chromosome biology. Originally identified as the molecular glue that holds sister chromatids together from DNA replication until cell division, co...
The implementation of Quality Management Standards (QMS) in health laboratories is essential to ensuring the traceability, reliability, and reproducibility of results, thus supporting compliance and continuous improvement. This study identifies and c...
Polyamines and their acetylated derivatives are promising biomarkers for noninvasive cancer diagnostics, creating demand for robust enzymatic tools for their detection. In this study, we screened several phylogenetically diverse yeast polyamine oxida...
Halotolerant plant growth-promoting bacteria offer a sustainable strategy to improve crop performance under saline conditions. This study evaluated Agave tequilana Weber var. Azul leaf juice was used as an alternative growth medium for Kocuria sedimi...
Network pharmacology studies of medicine–food homology plants have identified broad injury response pathways and hubs that cannot support compound-level or Parkinson’s disease (PD)-specific claims. We developed a traceable, non-weighted f...
Microalgae are recognized as sustainable biofactories for metabolites relevant to nutraceutical, pharmaceutical, and marine drug applications. Nannochloropsis salina is notable for its production of bioactive lipids, including the pharmaceutically re...
Global population growth has emphasised the need to have sustainable and alternative sources of nutrients. In this context, microalgae have emerged as a potential solution due to their rich biochemical composition, including high-quality proteins, ca...
Mass cytometers can record 40–50 parameters per single cell for millions of cells in a sample. Many methods have been developed to cluster phenotypically similar cells within cytometry data, but there are fewer methods to visualize activity and...
The use of invertebrates for sewage sludge bioconversion offers a sustainable strategy for waste valorization, yet species-specific effects on microbial communities and biosafety remain unclear. Here, we compared the impacts of the earthworm Eisenia ...
Filter-feeding bivalves can accumulate fecal bacteria and antimicrobial resistance determinants, yet routine regulatory monitoring relies mainly on quantitative Escherichia coli criteria. This study provides a whole-genome characterization of an ExPE...
Germination is a cost-effective bioprocessing technique for enhancing seed properties such as sesame seeds, an underutilized seed crop. This research evaluates modifications in physicochemical and antioxidant activity of white sesame seeds (Sesamum i...
Ajania achilleoides, a wild species with strong environmental adaptability, is a valuable germplasm resource for genetic improvement and functional gene studies. However, efficient in vitro regeneration and genetic transformation systems for this spe...
Hantaviruses are zoonotic RNA viruses responsible for two severe human diseases: hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS). Worldwide case fatality rates vary from 1% to 40%. Although single-layer gen...
A previous study demonstrated that quorum sensing (QS) genes from the psychrophilic bacterium Aliivibrio logei can be used in Escherichia coli to obtain bacterial cultures with controlled amounts of a target protein. However, the QS system may be ind...
Betalains are water-soluble pigments containing nitrogen, and they exist naturally in the plants of the order Caryophyllales. They have gained increasing attention in recent years because of their intense colours, antioxidant activity, and safety, th...
Background: Adeno-associated virus (AAV) vector-mediated gene transfer is an emerging treatment strategy for severe cardiac disorders with genetic etiology. We refined the AAV toolkit to achieve efficient and selective expression of the therapeutic t...
Vital pulp therapy aims to preserve pulp vitality by stimulating reparative processes. However, conventional approaches often result in incomplete tissue regeneration. Extracellular vesicles (EVs) have emerged as promising cell-free therapeutic agent...
Helicoverpa armigera is one of the most destructive polyphagous pests, yet the transcriptional organization underlying its digestive capacity remains poorly resolved. Here, we compiled 579 publicly available RNA-seq libraries representing 54 independ...
Biosafety Level 3 (BSL-3) laboratories are essential for handling high-risk pathogens and strengthening global health security. This study presents a patent landscape analysis of BSL-3-related technologies using the Derwent World Patents Index (DWPI)...
Sophorolipids (SLs) produced from Starmerella bombicola using four different secondary substrates such as refined, bleached, and deodorized palm olein (RBD PO), RBD palm kernel olein (RBD PKO), RBD coconut olein (RBD CO) and fatty acid methyl ester (...
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