Viral Resistance in HCV Infection

Dear Colleagues,

The introduction of new multi-genotypic direct-acting antivirals (DAA) in clinical practice has revolutionized HCV treatment, permitting the achievement of >95% rates of sustained virological response in many patients. However, virological failures can occur particularly if the treatments are sub-optimal and/or with too short a duration. Failure is often associated with the development of resistance. The wide genetic variability in terms of different genotypes and subtypes, together with the natural presence and/or easy development of resistance during treatment, are intrinsic characteristics of HCV that may affect the treatment outcome and the chances of achieving a virological cure.

This issue will explore, in detail, aspects of HCV variability and resistance to new interferon-free DAA regimens.

Dr. Francesca Ceccherini-Silberstein
Dr. Federico Garcia
Guest Editors

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